磷酸化S6核糖体蛋白抗体 (Ser240/244)

英文名称    Phospho-RPS6 (Ser240 + Ser244)    

中文名称    磷酸化S6核糖体蛋白抗体 (Ser240/244)    

别    名    RPS6 (phospho S240 + S244); p-RPS6 (phospho S240 + S244);RPS6 (phospho S240/S244); RPS6 (Phospho-Ser240/244); 40S ribosomal protein S6; Air8; DS6; Hemocytes enlarged; Hen; L(1)AIR8; Lethal (1) haemocytes enlarged; Lethal aberrant immune response 8; Lethal(1)abberant immune response[8]; Phosphoprotein NP33; Pp30; Ribosomal protein S6; RP S6; RPS 6; RpS6; RS6; RS6_HUMAN; S6; S6 Ribosomal Protein.    

磷酸化S6核糖体蛋白抗体 (Ser240/244)        

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  免疫学  染色质和核信号  信号转导  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-1000  ELISA=1:100-1000  IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    30kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human S6 Ribosomal Protein around the phosphorylation site of Ser240/244    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化S6核糖体蛋白抗体 (Ser240/244) 产品介绍    background:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Function:
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.

Post-translational modifications:
Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphrylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.

Similarity:
Belongs to the ribosomal protein S6e family.

Gene ID:
6194

Database links:

Entrez Gene: 6194 Human

Entrez Gene: 20104 Mouse

Entrez Gene: 667739 Mouse

Entrez Gene: 29304 Rat

Omim: 180460 Human

SwissProt: P62753 Human

SwissProt: P62754 Mouse

SwissProt: P62755 Rat

Unigene: 408073 Human

Unigene: 379007 Mouse

Unigene: 425090 Mouse

Unigene: 34341 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷酸化S6核糖体蛋白抗体 (Ser240/244) 

hz-1495R OCLN/Occludin  紧密连接蛋白抗体

hz-1241R Claudin 5  紧密连接蛋白5抗体

hz-1075R OCT1  阳离子转运器1抗体

hz-1077R OCT2  阳离子转运蛋白2抗体

hz-4052R Oct-1  胚胎干细胞关键蛋白1抗体

hz-5017R Oct-2  胚胎干细胞关键蛋白2抗体

hz-0830R Oct-4/POU5F1  胚胎干细胞关键蛋白抗体

hz-1111R Oct-3/Oct-4  胚胎干细胞关键蛋白抗体

hz-3816R Oct-4B(OCT4B-190)NT  胚胎干细胞关键蛋白190抗体(N端)

hz-1294R ODC  鸟氨酸脱羧酶抗体

hz-3687R OGG1/8 hydroxyguanine DNA glycosylase  8-羟基鸟嘌呤DNA糖基化酶

hz-1200R Omgp  少突细胞髓磷脂糖蛋白抗体

hz-2086R ompF(putative outer mhzbrane porin F protein)  小肠结肠炎耶尔森氏菌膜通道蛋白抗体

hz-2173R OLFM1  嗅球蛋白1抗体

hz-1081R OPCML  阿片样物质结合蛋白/细胞粘附分子样蛋白抗体

hz-0431R OPG  骨保护蛋白/护骨素抗体

hz-2695R RANK/CD265  核转录因子NF-κB受体抗体(核因子kB受体活化因子)

hz-0747R OPGL/RANKL/ODF  骨保护蛋白配体抗体(破骨细胞分化因子)

hz-0019R OPN/BSP  骨桥蛋白抗体(分泌型磷蛋白1)人

hz-0026R OPN/BSP  骨桥蛋白抗体(分泌型磷蛋白1)

hz-5111R Sigma1R  衰老相关基因8蛋白抗体

hz-1181R Orexin-A  增食欲素A/欲激素A

hz-5095R OSM/Oncostatin M  抑瘤素M抗体

hz-5096R OSMR/OSMRB  抑瘤素M受体抗体

hz-1110R Osterix  成骨相关转录因子抗体

hz-5089R OXCT1  含氧酸辅酶A转移酶1抗体

hz-0807R Os05g0477200 protein  水稻白叶枯病菌Os05g0477200蛋白抗体

hz-1314R Oxytocin R  催产素受体(缩宫素受体)抗体

hz-0283R OVA/SerpinB8  鸡卵白蛋白/卵清蛋白抗体

hz-1095R CD200R/Orexin receptor  丘脑分泌素受体抗体（食欲素受体）

hz-4065R P2X2/ATP receptor  嘌呤受体P2X2抗体

hz-4249R P2RX3/ATP receptor  嘌呤受体P2X3抗体

hz-6016R RBBP5  视网膜母细胞瘤结合蛋白5抗体

hz-1483R RBBP6/P2P-R  增殖潜能相关蛋白抗体

hz-1174R P14ARF  抑癌基因p14抗体