英文名称 phospho-PLB (Thr17)
中文名称 磷酸化心脏磷蛋白抗体
别 名 Phospholamban (phospho T17); p-Phospholamban (T17); Phospho-Phospholamban (Thr17); phospholamban(phospho Thr17); p-PLB(T17); Cardiac phospholamban; CMD1P; PLB; PLN; PPLA_HUMAN.
磷酸化心脏磷蛋白抗体
说 明 书 0.1ml
产品类型 磷酸化抗体
研究领域 心血管 细胞生物 信号转导
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 6kDa
细胞定位 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human phospho-PLB (Thr17)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
磷酸化心脏磷蛋白抗体 产品介绍 background:
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq, Jul 2008].
Function:
Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum
Subcellular Location:
Mitochondrion membrane. Sarcoplasmic reticulum.
Tissue Specificity:
Heart.
Post-translational modifications:
Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
DISEASE:
Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in PLN are the cause of cardiomyopathy familial hypertrophic type 18 (CMH18) [MIM:613874]. CMH18 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Similarity:
Belongs to the phospholamban family.
Database links:
Entrez Gene: 5350 Human
Entrez Gene: 18821 Mouse
Entrez Gene: 64672 Rat
Omim: 172405 Human
SwissProt: P26678 Human
SwissProt: P61014 Mouse
SwissProt: P61016 Rat
Unigene: 170839 Human
Unigene: 34145 Mouse
Unigene: 9740 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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企业名称
上海沪震实业有限公司
企业信息已认证
企业类型
信用代码
310112001371133
成立日期
2012-05-08
注册资本
100
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