英文名称 PIWIL1
中文名称 piwi样1蛋白抗体
别 名 PIWL1_HUMAN; Piwi-like protein 1.
piwi样1蛋白抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 免疫学 信号转导 转录调节因子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 99kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PIWIL1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
piwi样1蛋白抗体 产品介绍 Function:
1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Subunit:
Homotrimer. Binds to human and palm civet ACE2 and human CLEC4M/DC-SIGNR. Interacts with the accessory proteins 3a and 7a. {ECO:0000269|PubMed:14647384, ECO:0000269|PubMed:14670965, ECO:0000269|PubMed:15194747, ECO:0000269|PubMed:15496474, ECO:0000269|PubMed:16166518, ECO:0000269|PubMed:16840309}.
Subcellular Location:
Virion membrane {ECO:0000269|PubMed:15831954}; Single-pass type I membrane protein {ECO:0000269|PubMed:15831954}. Host endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Host cell membrane {ECO:0000269|PubMed:15831954}; Single-pass type I membrane protein {ECO:0000269|PubMed:15831954}. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly (By similarity). Some S oligomers are transported to the plasma membrane, where they may mediate cell-cell fusion. {ECO:0000250}.
Post-translational modifications:
he cytoplasmic Cys-rich domain is palmitoylated. Spike glycoprotein is digested by cathepsin CTSL within endosomes. {ECO:0000269|PubMed:17134730}.
Similarity:
Belongs to the coronaviruses spike protein family. {ECO:0000305}.
Gene ID:
9271
Database links:
Entrez Gene: 9271 Human
Entrez Gene: 57749 Mouse
Entrez Gene: 363912 Rat
Omim: 605571 Human
SwissProt: Q96J94 Human
SwissProt: Q9JMB7 Mouse
Unigene: 405659 Human
Unigene: 272720 Mouse
Unigene: 131387 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
piwi样1蛋白抗体
hz-5483R phospho-MEF2C(Thr300) 磷酸化肌细胞增强因子2C抗体
hz-0815R Megsin 丝氨酸蛋白酶抑制剂B7抗体
hz-4136R MEF2D 肌细胞特异性增强因子2D抗体
hz-5501R phospho-MEF2D(Ser180) 磷酸化肌细胞特异性增强因子2D抗体
hz-5502R phospho-MEF2D(Ser444) 磷酸化肌细胞特异性增强因子2D抗体
hz-0904R Melamine 三聚氰胺抗体
hz-0939R Melamine 三聚氰胺抗体
hz-0051R Melanoma HMB45/Melanoma/Melan-A/MART-1 黑色素瘤相关抗原/黑色素-A抗体
hz-1759R Met Enkephalin 甲硫氨酸脑啡肽抗体
hz-1433R MEK1/MAPKK1/MEKK1 MEK1/MAPKK1抗体(N-端)
hz-1988R Menin/Men1 Menin抑癌蛋白抗体
hz-6189R phospho-alpha Adducin(Ser726) 磷酸化内收蛋白a1抗体
hz-0401R Metal ion transporter 拟南介金属离子转运蛋白抗体
hz-0557R Mfn1 线粒体融合蛋白1抗体
hz-1002R MGMT O6甲基鸟嘌呤DNA甲基转移酶抗体
hz-1328R Metallothionein 金属硫蛋白抗体
hz-3885R Metallothionein 3 金属硫蛋白3抗体
hz-0900R LAMR1 层粘连蛋白受体1抗体(N端)
hz-1412R MTA1 肿瘤转移相关蛋白1抗体
hz-0901R LAMR1(CT) 层粘连蛋白受体1抗体(C端)
hz-2161R Myf6 生肌调节因子6抗体
hz-5101R MFAP3L 微丝相关蛋白3样抗体
hz-0832R MICA/MHC I MHC I类链相关蛋白A/组织相容性复合物1抗体
hz-4120R MHC class I antigen B 15 组织相关抗原HLA-B15抗体
hz-0909R Microsporidia protien 蜜蜂微孢子虫蛋白抗体
hz-0761R Midnolin isoform Protein 1 中脑核仁蛋白1抗体
hz-0762R MIDN 中脑核仁蛋白抗体
hz-1849R Midkine 中期因子/肝素结合生长因子抗体
hz-2992R MLK3/RHOE 丝氨酸/苏氨酸蛋白激酶MLK3抗体
hz-3280R Phospho-MLK3(Thr277/Ser281) 磷酸化丝氨酸/苏氨酸蛋白激酶MLK3抗体
hz-3950R MLX 转化因子样蛋白4抗体
hz-2797R MLC3F/MYL1/3 肌球蛋白轻链1/3抗体
hz-3295R Phospho-MYL(Ser19) 磷酸化肌球蛋白轻链2抗体
hz-2240R MYL3/Myosin light chain 3 肌球蛋白轻链3抗体
hz-4122R MAX protein Myc基因相关X因子抗体
hz-5425R phospho-MAX protein(Tyr123) 磷酸化Myc基因相关X因子抗体
hz-3505R Myt1 髓鞘转录因子1抗体
更多
企业名称
上海沪震实业有限公司
企业信息已认证
企业类型
信用代码
310112001371133
成立日期
2012-05-08
注册资本
100
经营范围
实验室分析仪器、仪器仪表、电子产品、化工产品及原料(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品)、一类医疗器械的销售,实业投资,投资咨询(除经纪),景观设计,从事生物科技领域内的技术开发、技术转让、技术咨询、技术服务,建筑装修装饰建设工程专业施工(凭许可资质经营),汽车租赁(除融资租赁)。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海沪震实业有限公司
公司地址
上海市杨浦区密云路1018号复旦科技园808室
客服电话