嗜酸性粒细胞颗粒关键碱性蛋白抗体

英文名称    PRG2    

中文名称    嗜酸性粒细胞颗粒关键碱性蛋白抗体    

别    名    BMPG; EMBP; Eosinophil granule major basic protein; Major Basic Protein; Eosinophil major basic protein; MBP; MBP1; Natural killer cell activator; Pregnancy-associated major basic protein; PRG 2; PRG2; PRG2_HUMAN; Proteoglycan 2; Proteoglycan 2 bone marrow; Proteoglycan 2 preproprotein.    

嗜酸性粒细胞颗粒关键碱性蛋白抗体        

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  自然杀伤细胞  淋巴细胞      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    25kDa    

细胞定位    细胞浆 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human PRG2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

嗜酸性粒细胞颗粒关键碱性蛋白抗体产品介绍    background:
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

Function:
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Subunit:
In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.

Subcellular Location:
Bone marrow proteoglycan: Secreted. Note=The proform is secreted. 
Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).

Tissue Specificity:
High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.

Post-translational modifications:
Nitrated.

Similarity:
Contains 1 C-type lectin domain.

Gene ID:
5553

Database links:

Entrez Gene: 5553 Human

Omim: 605601 Human

SwissProt: P13727 Human

Unigene: 512633 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

嗜酸性粒细胞颗粒关键碱性蛋白抗体

hz-1425R MAP3K5/ASK1/MEKK5  细胞凋亡信号调节激酶1抗体

hz-3007R phospho-ASK1 (Ser966)  磷酸化细胞凋亡信号调节激酶1抗体

hz-3029R phospho-ASK1(Ser967)  磷酸化细胞凋亡信号调节激酶1抗体

hz-3031R phospho-ASK1(Thr845)  磷酸化细胞凋亡信号调节激酶1抗体

hz-5436R phospho-ASK1(Ser83)  磷酸化细胞凋亡信号调节激酶1抗体

hz-5437R phospho-ASK1(Ser1033)  磷酸化细胞凋亡信号调节激酶1抗体

hz-4123R phospho-MEK3(Thr222)  磷酸化丝裂原活化蛋白激酶激酶3抗体

hz-0792R Maspin  抑癌基因抗体

hz-1723R MASP  甘露聚糖结合凝集素丝氨酸肽酶1抗体

hz-4693R MAL  MAL蛋白抗体

hz-1980R MASP2  甘露聚糖结合凝集素丝氨酸肽酶2抗体

hz-0531R Matriptase  蛋白裂解酶（一种新的癌基因）抗体

hz-6130R RbAp48  视网膜母细胞瘤结合蛋白P48抗体

hz-0380R MBP  髓鞘碱性蛋白（磷脂碱性蛋白）抗体

hz-6131R FAM123B/AMER1/Wilms tumor on the X  肾母细胞瘤基因X染色体蛋白抗体

hz-5474R phospho-MBP(Thr232)  磷酸化髓鞘碱性蛋白抗体

hz-0271R Cytomegalovirus pp65   巨细胞病毒PP65/CMV低基质磷脂蛋白抗体

hz-5475R phospho-MBP(Tyr203)  磷酸化髓鞘碱性蛋白抗体

hz-2271R HCMV  人巨细胞病毒抗体

hz-0896R HCMV UL23  人巨细胞病毒UL23抗体

hz-0808R HCMV UL49  人巨细胞病毒UL49蛋白抗体

hz-2274R HCMV UL49  人巨细胞病毒UL49蛋白抗体

hz-4205R hnRNP F  异质核糖核蛋白F抗体

hz-4300R hnRNP L  异质核糖核蛋白L抗体

hz-6134R WNT4  信号通路Wnt4抗体

hz-6135R Wnt6  信号通路Wnt6抗体

hz-6136R Adenovirus 5 E1A  腺病毒早期E1A蛋白抗体

hz-1101R MCP1/CCL2  单核细胞趋化蛋白1抗体

hz-1955R MCP1/CCL2  单核细胞趋化蛋白1抗体

hz-1984R MCP-2/CCL8  单核细胞趋化蛋白2抗体

hz-1985R MCP-2/CCL8  单核细胞趋化蛋白2抗体(小鼠)

hz-1986R MCP-3/CCL7  单核细胞趋化蛋白3抗体

hz-1987R MCP-3/CCL7  单核细胞趋化蛋白3抗体

hz-2477R CCL9/CCL10/MIP-1 gamma/SCYA10  巨噬细胞炎症蛋白-1γ抗体

hz-2725R Mast Cell Tryptase  肥大细胞蛋白酶7抗体