信号转导和转录激活因子4抗体

英文名称    STAT4    

中文名称    信号转导和转录激活因子4抗体    

别    名    signal transducers and activators of transduction 4; STAI4; STAT 4; STAT4; STATI4; STAT4_HUMAN.    

信号转导和转录激活因子4抗体  

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  发育生物学  信号转导  细胞凋亡  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    85kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human STAT4    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

信号转导和转录激活因子4抗体产品介绍    background:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].

Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

Subunit:
Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP (By similarity). The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.

Subcellular Location:
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Post-translational modifications:
Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity.

DISEASE:
Genetic variations in STAT4 are associated with susceptibility to systemic lupus erythematosus type 11 (SLEB11) [MIM:612253]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. 
Genetic variations in STAT4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

Similarity:
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.

Gene ID:
6775

Database links:

Entrez Gene: 6775 Human

Entrez Gene: 20849 Mouse

Entrez Gene: 367264 Rat

Omim: 600558 Human

SwissProt: Q14765 Human

SwissProt: P42228 Mouse

SwissProt: Q66HB2 Rat

Unigene: 735572 Human

Unigene: 80642 Human

Unigene: 1550 Mouse

Unigene: 137580 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

信号转导和转录激活因子4抗体

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