Rab27a蛋白抗体

英文名称    Rab27a    

中文名称    Rab27a蛋白抗体    

别    名    GS2; GTP-binding protein Ram; HsT18676; MGC117246; Rab-27; RAB-27A; RAB27; RAB27A; RAB27A member RAS oncogene family; RAM; Ras-related protein Rab-27A; Ras-related protein Rab27A; RB27A_HUMAN.    

Rab27a蛋白抗体        

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  转录调节因子  合成与降解  转运蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    25kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RAM-11    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

Rab27a蛋白抗体产品介绍    background:
Summary: The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq]. 

Function:
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

Subunit:
Binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5 (By similarity). Binds MLPH and SYTL2. Interacts with UNC13D.

Subcellular Location:
Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles.

Tissue Specificity:
Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.

DISEASE:
Griscelli syndrome 2 (GS2) [MIM:607624]: Rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

Gene ID:
5873

Database links:

Entrez Gene: 5873 Human

Entrez Gene: 11891 Mouse

Entrez Gene: 50645 Rat

Omim: 603868 Human

SwissProt: P51159 Human

SwissProt: Q9ERI2 Mouse

SwissProt: P23640 Rat

Unigene: 654978 Human

Unigene: 480676 Mouse

Unigene: 37360 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

Rab27a蛋白抗体

hz-3770R Histone H3 (Di Methyl K4)  二甲基化组蛋白H3K4抗体

hz-3772R Histone H3 (Di Methyl K9)  二甲基化组蛋白H3K9抗体

hz-5385R Phospho-Histone H3(Ser28)  磷酸化组蛋白H3抗体

hz-3773R Histone H3 (Di Methyl K27)  三甲基化组蛋白H3抗体

hz-3774R Acetyl-Histone H3(K23)  乙酰化组蛋白H3抗体

hz-3775R Acetyl-Histone H3(K18)  乙酰化组蛋白H3抗体

hz-3776R Acetyl-Histone H3(K9)  乙酰化组蛋白H3抗体

hz-3748R Acetyl and phospho-Histone H3(Ac-K9/p-Ser10)  乙酰化和磷酸化组蛋白H3抗体

hz-5386R Phospho-Histone H3(Thr3)  磷酸化组蛋白H3抗体

hz-3826R Histone H4  组蛋白H4抗体

hz-3746R Acetyl-Histone H4(K12)  乙酰化组蛋白H4抗体

hz-4016R Acetyl-Histone H4(K8)  乙酰化组蛋白H4抗体

hz-1413R Histone H1  组蛋白H1抗体

hz-3176R phospho-Histone H1(Thr146)  磷酸化组蛋白H1抗体

hz-0931R Acetyl-Histone H1b(K53)  乙酰化组蛋白H1b抗体

hz-3171R phospho-Histone H1.4(Thr18)  磷酸化组蛋白H1.4抗体

hz-0483R Histone H3-like protein  组蛋白H3样抗体

hz-0620R Histone H3-like protein  组蛋白H3样抗体

hz-0621R Histone H3-like protein  组蛋白H3样蛋白抗体

hz-5708R KMT1A/SUV39H1  组蛋白H3 K9甲基转移酶抗体

hz-1737R phospho-Histone H1.4(Ser27)  磷酸化组蛋白H1,4样蛋白抗体

hz-1414R HDAC1/HD1  组蛋白去乙酰化酶1抗体

hz-5387R phospho-HDAC1(Ser423)  磷酸化组蛋白去乙酰化酶1抗体

hz-5388R phospho-HDAC1(Ser423+Ser421)   磷酸化组蛋白去乙酰化酶1抗体

hz-1813R HDAC2/HD2  组蛋白去乙酰化酶2抗体

hz-5389R phospho-HDAC2(Ser394)  磷酸化组蛋白去乙酰化酶2抗体

hz-1819R HDAC3/HD3  组蛋白去乙酰化酶3抗体

hz-3174R Phospho-HDAC3 (Ser424)  磷酸化组蛋白去乙酰化酶3抗体

hz-2809R HDAC4  组蛋白去乙酰化酶4抗体

hz-2810R HDAC5  组蛋白去乙酰化酶5抗体

hz-2811R HDAC6  组蛋白去乙酰化酶6抗体

hz-3215R phospho-HDAC6 (Ser22)  磷酸化组蛋白去乙酰化酶6抗体

hz-2890R HDAC7  组蛋白去乙酰化酶7抗体

hz-3216R phospho-HDAC7 (Ser318)  磷酸化组蛋白去乙酰化酶7抗体

hz-2891R HDAC8  组蛋白去乙酰化酶8抗体

hz-3127R phospho-HDAC8(Ser39)  磷酸化组蛋白去乙酰化酶8抗体

hz-2892R HDAC9  组蛋白去乙酰化酶9抗体

hz-2893R HDAC10  组蛋白去乙酰化酶10抗体

hz-2894R HDAC11  组蛋白去乙酰化酶11抗体

hz-2895R HDAC12  组蛋白去乙酰化酶12抗体

hz-0287R His tag  聚组氨酸抗体标签抗体

hzm-0287M His tag(2D5)  小鼠抗聚组氨酸单克隆抗体

hz-3992R Hexokinase 1  己糖激酶1抗体

hz-3993R Hexokinase 2/HK2  己糖激酶2抗体

hz-3994R Hexokinase 3  己糖激酶3抗体

hz-0899R His tag(CT)  聚组氨酸抗体g标签抗体（C端）