核糖核苷酸还原酶1抗体

英文名称    RRM1    

中文名称    核糖核苷酸还原酶1抗体    

别    名    ribonucleotide reductase R1 mRNA; R1; Ribonucleoside diphosphate reductase large subunit ; Ribonucleoside diphosphate reductase M1 chain; Ribonucleoside diphosphate reductase subunit M1; Ribonucleotide reductase large chain; Ribonucleotide reductase large subunit; Ribonucleotide reductase M1 polypeptide; Ribonucleotide reductase R1 subunit; RIR 1; RIR1; RR 1; RR1; RRM 1; RIR1_HUMAN.    

 核糖核苷酸还原酶1抗体         

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  染色质和核信号  激酶和磷酸酶  细胞分化      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    90kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RRM1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

 核糖核苷酸还原酶1抗体  产品介绍    background:
RRM1 (Ribonucleotide reductase M1 polypeptide) is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer to treatment.

Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Subunit:
Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B.

Subcellular Location:
Cytoplasm.

Similarity:
Belongs to the ribonucleoside diphosphate reductase large chain family. 
Contains 1 ATP-cone domain.

Gene ID:
6240

Database links:

Entrez Gene: 6240 Human

Entrez Gene: 20133 Mouse

Entrez Gene: 685579 Rat

Omim: 180410 Human

SwissProt: P23921 Human

SwissProt: P07742 Mouse

Unigene: 445705 Human

Unigene: 197486 Mouse

Unigene: 162454 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

 核糖核苷酸还原酶1抗体  

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