络丝蛋白抗体

英文名称    Reelin    

中文名称    络丝蛋白抗体    

别    名    Reelin; Reeler; RELN; RL; LIS2; PRO1598; RELN_HUMAN.    

络丝蛋白抗体     

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  神经生物学  细胞凋亡      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Guinea Pig,     

产品应用    ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    400-450;300;180-200kDa    

细胞定位    分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RELN    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

络丝蛋白抗体产品介绍    background:
Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in “reeler” mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1 in a signaling pathway that controls cell positioning in the developing brain and is also thought to be a direct effector of the neurotrophin BDNF.

Function:
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.

Subcellular Location:
Secreted 

Tissue Specificity:
High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level). 

Post-translational modifications:
N-glycosylated; more than 90% of the glycans are sialylated. 

Similarity:
Belongs to the ALB/AFP/VDB family. 
Contains 3 albumin domains. 

Gene ID:
5649

Database links:

Entrez Gene: 5649 Human

Entrez Gene: 19699 Mouse

Entrez Gene: 24718 Rat

Omim: 600514 Human

SwissProt: P78509 Human

SwissProt: Q60841 Mouse

SwissProt: P58751 Rat

Unigene: 655654 Human

Unigene: 425236 Mouse

Unigene: 98353 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

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