英文名称 RBBP6
中文名称 增殖潜能相关蛋白抗体
别 名 Retinoblastoma-binding protein 6; proliferation potential protein related; p53-associated cellular protein of testis; Proliferation potential-related protein; Retinoblastoma-binding Q protein 1; Protein RBQ-1; My038; PACT; Protein P2P-R; RBBP6_HUMAN; P2P-R.
增殖潜能相关蛋白抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 发育生物学 信号转导 细胞周期蛋白
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 201kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from humna P2PR
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 增殖潜能相关蛋白抗体产品介绍 background:
he retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
Subunit:
Interacts with p53/TP53 and RB1. Interacts also with MDM2 and YBX1. Interacts with NEK6.
Subcellular Location:
Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome.
Tissue Specificity:
Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
Post-translational modifications:
Phosphorylated by NEK6.
Similarity:
Contains 1 CCHC-type zinc finger.
Contains 1 DWNN domain.
Contains 1 RING-type zinc finger.
Gene ID:
5930
Database links:
Entrez Gene: 5930 Human
Entrez Gene: 19647 Mouse
Entrez Gene: 308968 Rat
Omim: 600938 Human
SwissProt: Q7Z6E9 Human
SwissProt: P97868 Mouse
Unigene: 188553 Human
Unigene: 4480 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
增殖潜能相关蛋白抗体
hz-0617R Cobra poison Protein 眼镜蛇蛇毒蛋白抗体
hz-5987R ARL11 ADP核糖基化因子样11抗体
hz-5131R GLO1 乙二醛酶1抗体
hz-5988R ARMCX1 ARM重复X连锁蛋白ARMCX1抗体
hz-4291R BARD1 乳腺癌易感基因环状结构域蛋白抗体
hz-0038R GLP-1 (7-36) 胰高血糖素样肽-1抗体
hz-0933R GLP-1 胰高血糖素样肽-1抗体
hz-5989R ARMCX2 ARM重复X连锁蛋白ARMCX2抗体
hzm-0933M GLP-1(1G9) GLP-1单克隆抗体
hz-4584R GRPP 胰高血糖素相关肽抗体
hz-4585R GRPP 胰高血糖素相关肽抗体
hz-5990R ARMCX3 ARM重复X连锁蛋白ARMCX3抗体
hz-1559R GLP-1R 胰高血糖素样肽-1受体抗体
hz-3796R Glucagon 胰高血糖素抗体
hz-3945R Glucagon Receptor 胰高血糖素受体抗体
hz-5992R BRCAA1/RBBP1L1 乳腺癌相关抗原BRCAA1抗体
hz-5993R HBEX2/Bex1 脑组织表达X连锁蛋白1抗体
hz-0208R GLP-2 胰高血糖素样肽-2抗体
hz-0841R GLP-2 胰高血糖素样肽-2抗体
hz-5994R BCSC1 乳腺癌抑癌蛋白抗体
hz-0472R GLUT1 葡萄糖转运蛋白1抗体
hz-0351R GLUT2 葡萄糖转运蛋白2抗体
hz-1207R GLUT3 葡萄糖转运蛋白3抗体
hz-0384R GLUT4 葡萄糖转运蛋白4抗体
hz-3988R GLUT5 葡萄糖转运蛋白5抗体
hz-4241R GLUT8 葡萄糖转运蛋白8抗体
hz-1524R GlyR alpha 1/2/3 甘氨酸受体alpha 1/2/3型抗体
hz-2540R GLUT12 葡萄糖转运蛋白12抗体
hz-0319R E1 glycoprotein 风疹病毒糖蛋白抗体
hz-2367R GM1(GS) 神经节苷酯抗体
hz-0999R GM-CSF 粒细胞-巨噬细胞克隆刺激因子抗体
hz-3790R GM-CSF 粒细胞-巨噬细胞克隆刺激因子抗体
hz-1457R GM-CSFR alpha/CD116/CSF2RA 粒细胞-巨噬细胞集落刺激因子受体α抗体
hz-3689R GM-CSFR β/CSF2RB 粒细胞-巨噬细胞集落刺激因子受体β抗体
hz-5252R phospho-CSF2RB (Tyr766) 磷酸化粒细胞-巨噬细胞集落刺激因子受体β抗体
hz-3892R cGMP 环磷酸鸟苷抗体