G蛋白信号转导调节因子2抗体

英文名称    RGS2    

中文名称    G蛋白信号转导调节因子2抗体    

别    名    Basic helix-loop-helix phosphoprotein G0S8; Cell growth inhibiting protein 31; Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8 24kD; G0/G1 switch regulatory protein 8; GOS8; OTTHUMP00000060765; Regulator of G protein signaling 2; Regulator of G protein signalling 2 24kD; Regulators of G protein signaling XRGSVI; RGS 2.    

G蛋白信号转导调节因子2抗体         

说 明 书    0.1ml  0.2ml      

研究领域    免疫学  神经生物学  信号转导  生长因子和激素  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    24kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RGS2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

G蛋白信号转导调节因子2抗体  产品介绍    background:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq].

Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.

Subunit:
Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).

Subcellular Location:
Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus. 
Isoform 2: Cell membrane. Cytoplasm. Nucleus, nucleolus. 
Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus. 
Isoform 4: Cell membrane. Mitochondrion.

Tissue Specificity:
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).

Post-translational modifications:
Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.

Similarity:
Contains 1 RGS domain.

Gene ID:
5997

Database links:

Entrez Gene: 5997 Human

Entrez Gene: 19735 Mouse

Entrez Gene: 84583 Rat

Omim: 600861 Human

SwissProt: P41220 Human

SwissProt: O08849 Mouse

SwissProt: Q9JHX0 Rat

Unigene: 78944 Human

Unigene: 28262 Mouse

Unigene: 1892 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

G蛋白信号转导调节因子2抗体  

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hz-0154R GAP43  神经生长相关蛋白43

hz-5962R BORIS/CT27  肿瘤/睾丸抗原27抗体（高迁移率族蛋白）

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hz-0835R GAPDH  3-磷酸甘油醛脱氢酶（兔来源免疫组化用抗体）

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