Ras蛋白脑组织同源类似物RHEB蛋白抗体

英文名称    RHEB    

中文名称    Ras蛋白脑组织同源类似物RHEB蛋白抗体    

别    名    GTP-binding protein Rheb; MGC111559; Ras homolog enriched in brain 2; Ras homolog enriched in brain; RHEB 2; RHEB-2 RHEB2; RHEB_HUMAN.    

Ras蛋白脑组织同源类似物RHEB蛋白抗体      

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  免疫学  神经生物学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    20kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RHEB    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

Ras蛋白脑组织同源类似物RHEB蛋白抗体  产品介绍    background:
Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demon-strate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.

Function:
Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.

Subunit:
Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2.

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side.

Tissue Specificity:
Ubiquitous. Highest levels observed in skeletal and cardiac muscle.

Post-translational modifications:
Farnesylation is important for efficiently activating mTORC1-mediated signaling. 
Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation (By similarity). 

Similarity:
Belongs to the small GTPase superfamily. Rheb family.

Gene ID:
6009

Database links:

Entrez Gene: 6009 Human

Omim: 601293 Human

SwissProt: Q15382 Human

Unigene: 283521 Human

Unigene: 568850 Human

Unigene: 647068 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

Ras蛋白脑组织同源类似物RHEB蛋白抗体  

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