核转录因子NFKB-RelB蛋白抗体

英文名称    RelB    

中文名称    核转录因子NFKB-RelB蛋白抗体    

别    名    I REL; IREL; Nuclear factor of kappa light polypeptide gene enhancer in B cells 3; RelB; Reticuloendotheliosis viral oncogene homolog B; Transcription factor RelB; v rel avian reticuloendotheliosis viral oncogene homolog; v rel reticuloendotheliosis viral oncogene homolog B; RELB_HUMAN; I-Rel.    

核转录因子NFKB-RelB蛋白抗体           

说 明 书    0.2ml      

研究领域    肿瘤  免疫学  信号转导  细胞凋亡  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    64kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RelB    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

核转录因子NFKB-RelB蛋白抗体    产品介绍    background:
The NFKB complex consists of NFKB1 or NFKB2 bound to REL, RELA, or RELB. The NFKB complex is inhibited by I kappa B proteins (NFKBIA, or NFKBIB), which inactivate NF kappa B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I kappa B proteins by kinases (IKBKA, or IKBKB,) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF kappa B complex. For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT.

Function:
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.

Subunit:
Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID.

Subcellular Location:
Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Co-localizes with NEK6 in the centrosome.

Post-translational modifications:
Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation.

Similarity:
Contains 1 RHD (Rel-like) domain.

Gene ID:
5971

Database links:

Entrez Gene: 5971 Human

Omim: 604758 Human

SwissProt: Q01201 Human

Unigene: 654402 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

核转录因子NFKB-RelB蛋白抗体    

hz-3908R LTA4H  白三烯A4水解酶抗体

hz-2654R LTB4-R1/BLTR  白三烯B4受体1抗体

hz-2655R LTB4-R2  白三烯B4受体2抗体

hz-0484R Iumbrokinase  蚓激酶抗体

hz-1971R Lxn/Latexin  羧肽酶抑制剂抗体

hz-2342R LXR alpha  肝脏X受体抗体

hz-2576R Ly-6G/Gr-1  淋巴细胞抗原6G抗体

hz-2661R LY-86/MD-1  MD-1蛋白抗体

hz-2662R LY-96/MD-2  MD-2蛋白抗体

hz-0816R Lysozyme  溶菌酶抗体

hz-2906R Lyn  膜相关蛋白酪氨酸激酶Lyn抗体

hz-3256R Phospho-Lyn (Tyr507)  膜相关蛋白酪氨酸激酶Lyn抗体

hz-3257R Phospho-Lyn (Tyr396)  磷酸化膜相关蛋白酪氨酸激酶Lyn抗体

hz-3258R Phospho-Lyn (Tyr497)  磷酸化膜相关蛋白酪氨酸激酶Lyn抗体

hz-1311R LYVE-1  淋巴管内皮透明质酸受体抗体

hz-3949R LYK5  蛋白激酶LYK5抗体

hz-5138R LZTFL1  亮氨酸拉链转录因子样1抗体

hz-0101R M2-PK/PKM2  丙酮酸激酶-M2抗体

hz-3334R Phospho-PKM2 (Tyr105)  磷酸化丙酮酸激酶M2抗体

hz-0102M M2-PK/PKM2  小鼠抗丙酮酸激酶-M2抗体

hz-0101M M2-PK (pyruvate Kinase M2)  丙酮酸激酶-M2

hz-2217R Integrin alpha E2  整合素alpha E2 抗体

hz-1804R Integrin alpha L/CD11a  整合素αL抗体

hz-1014R CD11b/Integrin αM/Integrin Alpha M  整合素αM/巨噬细胞表面分子抗体

hz-2508R Integrin Alpha X/CD11c  整合素αX抗体

hz-2659R MARCO  巨噬细胞清道夫受体抗体

hz-6023R BST1/CD157  骨髓基质干细胞抗原1抗体

hz-2909R MARCKS  丙氨酸蛋白激酶C底物Marcks抗体

hz-3263R Phospho-MARCKS (Ser152/156)  磷酸化丙氨酸蛋白激酶C底物Marcks抗体

hz-3359R Phospho-MARCKS (Ser162)  磷酸化丙氨酸蛋白激酶C底物Marcks抗体

hz-5500R Phospho-MARCKS(Ser170)  磷酸化丙氨酸蛋白激酶C底物Marcks抗体

hz-1595R MAD1  Mad1抗体

hz-0642R MAdCAM-1  粘膜血管定居因子抗体

hz-3859R MAGP2  纤微丝相关糖蛋白2抗体

hz-1975R DAXX  死亡相关蛋白6抗体(Fas死亡区相关蛋白)

hz-3135R Phospho-FADD(Ser191)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5288R phospho-DAXX (Ser213)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5291R phospho-DAXX (Ser495)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5292R phospho-DAXX (Ser517)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5293R phospho-DAXX (Ser671)  磷酸化Fas相关死亡结构域蛋白抗体

hz-0924R Mafa  v-maf 肌腱膜纤维肉瘤癌基因同源物A抗体

hz-2591R MAFbx/Fbx32  泛素蛋白连接酶抗体