Ras特异性鸟嘌呤核苷酸释放因子1

英文名称    RASGRF1    

中文名称    Ras特异性鸟嘌呤核苷酸释放因子1    

别    名    CDC25; CDC25L; GNRP; GRF1; GRF55; Guanine nucleotide exchange factor; Guanine nucleotide releasing factor 55 kD; Guanine nucleotide releasing protein; Guanine nucleotide-releasing protein; H GRF55; HGRF55; PP13187; Ras protein specific guanine nucleotide releasing factor 1; Ras specific guanine nucleotide releasing factor; Ras specific guanine nucleotide releasing factor CDC25 homolog; Ras specific nucleotide exchange factor CDC25; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25; RASGRF1; RGRF1_HUMAN.    

Ras特异性鸟嘌呤核苷酸释放因子1     

说 明 书    0.2ml      

研究领域    免疫学  信号转导  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Guinea Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    145kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RASGRF1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Ras特异性鸟嘌呤核苷酸释放因子1 产品介绍    background:
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

Function:
Promotes the exchange of Ras-bound GDP by GTP.

Subunit:
Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability.

Post-translational modifications:
Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome. 
Ubiquitinated and degraded following phosphorylation by PLK2 By similarity). 
Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC seems not to have an effect on stimulation activity.

Similarity:
Contains 1 DH (DBL-homology) domain. 
Contains 1 IQ domain. 
Contains 1 N-terminal Ras-GEF domain. 
Contains 2 PH domains. 
Contains 1 Ras-GEF domain.

Gene ID:
5923

Database links:
Entrez Gene: 5923 Human

Entrez Gene: 192213 Rat

Omim: 606600 Human

SwissProt: Q13972 Human

SwissProt: P28818 Rat

Unigene: 459035 Human

Unigene: 135776 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

Ras特异性鸟嘌呤核苷酸释放因子1 

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