G蛋白家族RAB21蛋白抗体

英文名称    RAB21    

中文名称    G蛋白家族RAB21蛋白抗体    

别    名    RAB 21; RAB21; RAB-21; RAB21, member RAS oncogene family; Ras-related protein Rab-21; RAB21_HUMAN.    

G蛋白家族RAB21蛋白抗体        

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  免疫学  信号转导  细胞周期蛋白  细胞粘附分子  G蛋白偶联受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    24kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RAB21.    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

G蛋白家族RAB21蛋白抗体   产品介绍    background:
RAB21 belongs to the family of small GTP-binding proteins that regulate intracellular vesicles targeting. RAB21 regulates integrin internalization and recycling and it is essential for normal cell division and defects in this trafficking may contribute to multinucleation and genomic instability.

Function:
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis.

Subunit:
Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By similarity). Interacts with RABGEF1 (via VPS9 domain).

Subcellular Location:
Endoplasmic reticulum membrane; Lipid-anchor (By similarity). Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Note=In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm. During mitosis, in mid-telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells.

Tissue Specificity:
Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

Database links:
UniProtKB/Swiss-Prot: Q9UL25.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

G蛋白家族RAB21蛋白抗体   

hz-0899R His tag(CT)  聚组氨酸抗体g标签抗体（C端）

hz-0833R FLAG Tag (NT)  FLAG Tag标签抗体（N端）

hz-0879R FLAG Tag (CT)  FLAG Tag标签抗体（C端）

hz-0965R FLAG Tag(CT)  FLAG Tag标签抗体（C端）

hz-2735R GstP1/GST class-pi  谷胱甘肽硫转移酶pi基因抗体

hz-2107R T7 tag  T7 tag标签抗体

hz-2109R V5 tag  V5 tag标签抗体

hz-2112R KT3 tag  KT3 tag抗体

hz-2110R VSV-G tag  VSV-G tag标签抗体

hz-0241R HIV gp120  艾滋病病毒抗体

hz-0239R HIV gp41  艾滋病病毒抗体

hz-0785R HIV-1 ENV(gp160)  艾滋病病毒-1包膜糖蛋白抗体

hz-0786R HIV-1 ENV (gp160)  艾滋病病毒-1包膜糖蛋白抗体

hz-2355R HLA Class 1 ABC/HLAabc  人类白细胞抗原A抗体

hz-2387R MHC class I  组织相容性复合体1多肽抗体

hz-4107R MHC Class II/MRC OX-6  组织相容性复合体2抗体

hz-4298R HLA DMβ  组织相容性复合体β抗体

hz-1198R HLA-DR  HLA-DR抗体

hz-0752R HLA B/HLA G  人类白细胞抗原G抗体

hz-1279R HLA E  人类白细胞抗原E抗体

hz-1030R HMGA1/HMG-I/HMG-Y  高迁移率族蛋白A1抗体

hz-0556R HMGA2  高迁移率族蛋白A2抗体

hz-0664R HMGB1  高迁移率族蛋白B1抗体

hz-1820R HMGB4  高迁移率族蛋白B4抗体

hz-5067R HMGCL  三羟基三甲基辅酶A裂解酶抗体

hz-5068R HMGCR  三羟基三甲基辅酶A还原酶抗体

hz-4063R phospho-HMGCR(Ser872)  磷酸化三羟基三甲基辅酶A还原酶抗体

hz-5069R HMGCS1  三羟基三甲基辅酶A合成酶1

hz-5070R HMGCS2  三羟基三甲基辅酶A合成酶2抗体

hz-1405R HNF1/TCF1/HNF1A  肝细胞核因子1α抗体

hz-3828R HNF4/TCF4/HNF4A  肝细胞核因子4α抗体