Ras样蛋白家族10A抗体

英文名称    RASL10A    

中文名称    Ras样蛋白家族10A抗体    

别    名    Ras like protein family member 10A; Ras like protein RRP22; RAS like, family 10, member A; RAS related on chromosome 22; Ras related protein on chromosome 22; Ras related protein on chromosome 22 homolog; RASL10A protein; Rasl10a RAS like, family 10, member A; RP23 64E17.6 antibody RRP22; RSLBA_HUMAN.    

Ras样蛋白家族10A抗体         

说 明 书    0.2ml      

研究领域    肿瘤  免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    27kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RASL    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

Ras样蛋白家族10A抗体 产品介绍    background:
Ras proteins are members of a superfamily of related small GTPases. RRP22 can be posttranslationally modified by farnesyl. RRP22 inhibits cell growth and promotes caspase-independent cell death. The specific function of RASL10A is not yet known.

Function:
Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity). 

Subunit:
Interacts with UBF/UBTF (By similarity).

Subcellular Location:
Nucleus, nucleolus (By similarity). Note=Associates with rDNA transcription unit throughout the cell cycle (By similarity).

Tissue Specificity:
Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells. 

Similarity:
Belongs to the small GTPase superfamily. Ras family.

Database links:
UniProtKB/Swiss-Prot: Q6T310.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

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