英文名称 Robo
中文名称 轴突导向受体抗体
别 名 Axon guidance receptor; Deleted in U twenty twenty; DUTT 1; DUTT1; FLJ21882; H Robo 1; H-Robo-1; hRobo 1; Robo 1; Robo1; ROBO1_HUMAN; Roundabout 1; Roundabout axon guidance receptor homolog 1; Roundabout homolog 1; Roundabout homolog1 precurser; Roundabout1; SAX 3; SAX3.
轴突导向受体抗体
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 免疫学 神经生物学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 181kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Robo.
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
轴突导向受体抗体产品介绍 background:
Specialized cells at the midline, which separates the left and right halves of the CNS, have a number of roles in directing growth cone behavior (1). In the vertebrate spinal cord, the insect ventral nerve cord and in C. elegans, midline cells produce guidance cues such as nectins and slit, which act as attractants and repellents, respectively (1). These cells may act as gatekeepers to prevent axons from crossing the midline and to induce a switch in growth cone responsiveness to guidance cues beyond the gateway (1). One such gatekeeper, Robo, is an axon guidance receptor that defines a novel subfamily of Ig superfamily proteins that are conserved from fruit flies to mammals (2,3). Robo acts as a receptor for the repellent Slit and functions in a cell-autonomous fashion (1-3). Non-crossing axons express high levels of Robo, whereas crossing axons express low levels of Robo before reaching the midline and high levels after they cross (1). Robo1 and Robo2 are two human homologs of the Drosophila protein Roundabout (2-4). Robo1 is also homologous to the C. elegans gene sax3, whereas Robo2 is homologous to the zebrafish gene astray (5,6).
Function:
Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.
Subcellular Location:
Membrane.
Tissue Specificity:
Widely expressed, with exception of kidney.
Post-translational modifications:
Ubiquitinated. May be deubiquitinated by USP33.
Similarity:
Belongs to the immunoglobulin superfamily. ROBO family.
Contains 3 fibronectin type-III domains.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴突导向受体抗体
hz-3183R phospho-GAB2 (Ser623) 磷酸化接头蛋白Gab 2抗体
hz-5955R RASSF6 RAS家族关联结构域蛋白6抗体
hz-1232R GABRA1 G1氨基丁酸A型受体α1抗体
hz-0533R GABABR1 gamma氨基丁酸B型受体1抗体
hz-5358R phospho-GABBR1 (Ser923) 磷酸化gamma氨基丁酸B型受体1抗体
hz-1293R GABBR2/GB2 G氨基丁酸B型受体2抗体
hz-5356R phospho-GABBR2 (Ser783) 磷酸化G氨基丁酸B型受体2抗体
hz-5357R phospho-GABBR2 (Ser892) 磷酸化G氨基丁酸B型受体2抗体
hz-4112R GABRG2/GABA A Receptor gamma 2 γ氨基丁酸γ2受体抗体
hz-5377R phospho-GABRG2(Ser327) 磷酸化γ氨基丁酸γ2受体抗体
hz-0325R GAD65 谷氨酸脱羧酶-65抗体
hz-5956R RHCE Rh血型C抗原抗体
hz-1302R GAD67 谷氨酸脱羧酶-67抗体
hz-5957R Styk1 丝氨酸/苏氨酸/酪氨酸激酶STYK1抗体
hz-0400R GAD65 谷氨酸脱羧酶-65抗体(C端)
hz-1776R GADD34 生长抑制DNA损伤基因34抗体
hz-1360R GADD45 生长抑制DNA损伤基因45抗体
hz-5904R GADD45B 生长抑制DNA损伤基因GADD45β抗体
hz-1361R GADD153/CHOP/DDIT3 GADD153抗体
hz-5177R phospho-GADD153 (Ser30) 磷酸化GADD153抗体
hz-5958R AF 4 protein 原癌基因AF4蛋白抗体
hz-0017M Galanin 神经节肽抗体
hz-5960R B MyB 转录因子MYB相关蛋白B抗体
hz-0721R Galectin 3 半乳糖凝集素3抗体
hz-3983R Galactose kinase/GALK1 半乳糖激酶1抗体
hz-1699R Galectin 9 半乳糖凝集素9抗体
hz-3984R GALT 磷酸半乳糖尿苷酸转移酶1抗体
hz-0154R GAP43 神经生长相关蛋白43
hz-5962R BORIS/CT27 肿瘤/睾丸抗原27抗体(高迁移率族蛋白)
hz-1641R phospho-GAP43(Ser41) 磷酸化神经生长相关蛋白43抗体
hz-5963R CDCA7L 细胞分裂周期相关蛋白JPO2抗体
hz-5964R ETS2 癌基因ETS2抗体
hz-0755R GAPDH 3-磷酸甘油醛脱氢酶(兔来源免疫组化用抗体)
hz-0835R GAPDH 3-磷酸甘油醛脱氢酶(兔来源免疫组化用抗体)
hz-5965R ETV7 转录因子ETV7抗体
hz-5966R LMO4 乳腺肿瘤自身抗原LMO4抗体
hz-0459R GAPDH 3-磷酸甘油醛脱氢酶(兔来源免疫组化用抗体)
hz-3795R GCDGP15/SABP 囊性组织液体蛋白15抗体
更多
企业名称
上海沪震实业有限公司
企业信息已认证
企业类型
信用代码
310112001371133
成立日期
2012-05-08
注册资本
100
经营范围
实验室分析仪器、仪器仪表、电子产品、化工产品及原料(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品)、一类医疗器械的销售,实业投资,投资咨询(除经纪),景观设计,从事生物科技领域内的技术开发、技术转让、技术咨询、技术服务,建筑装修装饰建设工程专业施工(凭许可资质经营),汽车租赁(除融资租赁)。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海沪震实业有限公司
公司地址
上海市杨浦区密云路1018号复旦科技园808室
客服电话