RAS蛋白样激活剂1抗体

英文名称    RASAL1    

中文名称    RAS蛋白样激活剂1抗体    

别    名    GAP1 like protein; MRASAL; RAS GTPase activating protein like; RAS protein activator like 1 (GAP1 like); RAS protein activator like 1; RASAL; Rasal1; rasGAP activating like protein 1; RasGAP-activating-like protein 1; RASGAP1 LIKE; RASL1_HUMAN.    

RAS蛋白样激活剂1抗体        

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  免疫学  信号转导  G蛋白偶联受体  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    90kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RASAL1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

RAS蛋白样激活剂1抗体 产品介绍    background:
Ras GTPase activating-like protein (RASAL) or RASAL1 is a member of the GAP1 family, and a Ca2+ sensor responding in-phase to repetitive Ca2+ signals by associating with the plasma membrane and deactivating Ras. It contains a conserved domain structure comprising N-terminal tandem C2 domains, a highly conserved central RasGAP domain, and a C-terminal pleckstrin-homology domain that is associated with a Bruton's tyrosine kinase motif. RASAL, like Ca2+ -promoted Ras inactivator (CAPRI, or RASAL4), is a cytosolic protein that undergoes a rapid translocation to the plasma membrane in response to receptor-mediated elevation in the concentration of intracellular free Ca2+, a translocation that activates its ability to function as a RasGAP. However, unlike RASAL4, RASAL undergoes an oscillatory translocation to the plasma membrane that occurs in synchrony with repetitive Ca2+ spikes.

Function:
Probable inhibitory regulator of the Ras-cyclic AMP pathway. 

Tissue Specificity:
Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea. 

Similarity:
Contains 1 Btk-type zinc finger.
Contains 2 C2 domains.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.

Database links:
UniProtKB/Swiss-Prot: O95294.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

RAS蛋白样激活剂1抗体 

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hz-5238R phospho-CDKN1A/P21 (Thr57)  磷酸化p21蛋白抗体

hz-5239R phospho-CDKN1A/P21 (Ser146)  磷酸化p21蛋白抗体

hz-5274R phospho-CDKN1A/P21 (Ser130)  磷酸化p21蛋白抗体

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hz-5227R phospho-CDKN1B/P27kip1 (Ser10)  磷酸化P27抗体/周期素依赖激酶抑制剂

hz-5228R phospho-CDKN1B/P27kip1 (Thr157)  磷酸化P27抗体/周期素依赖激酶抑制剂抗体

hz-5229R phospho-CDKN1B/P27kip1 (Thr187)  磷酸化P27抗体/周期素依赖激酶抑制剂抗体

hz-5236R phospho-CDKN1B/P27kip1 (Ser178)  磷酸化P27抗体/周期素依赖激酶抑制剂抗体

hz-5279R phospho-CDKN1B/P27kip1 (Thr198)  磷酸化P27抗体/周期素依赖激酶抑制剂抗体

hz-1204R P2Y1R/P2ry1  P2Y1受体抗体/嘌呤受体抗体

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hz-0427R P311 protein  神经再生相关蛋白抗体

hz-5090R P4HB  蛋白二硫键异构酶P4HB抗体

hz-0637R p38MAPK/MAPK14/p38Alpha  丝裂原活化蛋白激酶p38α抗体

hz-0636R P38 MAPK(Phospho-Thr180/Tyr182)  磷酸化-丝裂原活化蛋白激酶p38抗体（P-p38 MAPK）

hz-2210R phospho-p38 MAPK/MAPK14(Thr180/Tyr182)  磷酸化丝裂原活化蛋白激酶p38抗体

hz-1689R MKK3/MEK3  丝裂原活化蛋白激酶MKK3抗体

hz-3274R Phospho-MKK3(Ser189)/MKK6(Ser207)  磷酸化丝裂原活化蛋白激酶MKK3/6抗体

hz-4124R MEK5/MAP2K5  丝裂原活化蛋白激酶激酶5抗体

hz-5429R phospho-MEK5(Ser142)  磷酸化丝裂原活化蛋白激酶激酶5抗体

hz-1977R SEK1/MKK4  丝裂原活化蛋白激酶激酶4抗体

hz-3391R Phospho-MKK4(Ser80)  磷酸化丝裂原活化蛋白激酶激酶4抗体

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hz-3394R Phospho-SEK1/MKK4 (Ser257/Thr261)  磷酸化丝裂原活化蛋白激酶激酶4抗体

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hz-2911R MEK6  丝裂原活化蛋白激酶MKK6抗体

hz-3275R Phospho-MEK6 (Ser207)  磷酸化丝裂原活化蛋白激酶MKK6抗体