英文名称 RASAL1
中文名称 RAS蛋白样激活剂1抗体
别 名 GAP1 like protein; MRASAL; RAS GTPase activating protein like; RAS protein activator like 1 (GAP1 like); RAS protein activator like 1; RASAL; Rasal1; rasGAP activating like protein 1; RasGAP-activating-like protein 1; RASGAP1 LIKE; RASL1_HUMAN.
RAS蛋白样激活剂1抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 免疫学 信号转导 G蛋白偶联受体 G蛋白信号
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RASAL1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RAS蛋白样激活剂1抗体 产品介绍 background:
Ras GTPase activating-like protein (RASAL) or RASAL1 is a member of the GAP1 family, and a Ca2+ sensor responding in-phase to repetitive Ca2+ signals by associating with the plasma membrane and deactivating Ras. It contains a conserved domain structure comprising N-terminal tandem C2 domains, a highly conserved central RasGAP domain, and a C-terminal pleckstrin-homology domain that is associated with a Bruton's tyrosine kinase motif. RASAL, like Ca2+ -promoted Ras inactivator (CAPRI, or RASAL4), is a cytosolic protein that undergoes a rapid translocation to the plasma membrane in response to receptor-mediated elevation in the concentration of intracellular free Ca2+, a translocation that activates its ability to function as a RasGAP. However, unlike RASAL4, RASAL undergoes an oscillatory translocation to the plasma membrane that occurs in synchrony with repetitive Ca2+ spikes.
Function:
Probable inhibitory regulator of the Ras-cyclic AMP pathway.
Tissue Specificity:
Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea.
Similarity:
Contains 1 Btk-type zinc finger.
Contains 2 C2 domains.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.
Database links:
UniProtKB/Swiss-Prot: O95294.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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