RAS家族关联结构域蛋白6抗体

英文名称    RASSF6    

中文名称    RAS家族关联结构域蛋白6抗体    

别    名    Putative RAS binding protein; Ras association domain containing protein 6.RASF6_HUMAN    

RAS家族关联结构域蛋白6抗体        

说 明 书    0.2ml      

研究领域    肿瘤  免疫学  信号转导  G蛋白偶联受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    41kDa    

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RASSF6    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

RAS家族关联结构域蛋白6抗体产品介绍    background:
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012].

Function:
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity).

Subunit:
Interacts with MOAP1 (By similarity). Interaction with activated KRAS is still a matter of debate: interaction has been shown in the mouse (PubMed:17404571), but not in human (PubMed:17367779). Lack of interaction with MRAS, NRAS nor RRAS2 has also been reported (PubMed:17367779).

Tissue Specificity:
Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.

Similarity:
Contains 1 Ras-associating domain.
Contains 1 SARAH domain. 

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

RAS家族关联结构域蛋白6抗体

hz-4246R NFAT1/NFATc2  核因子活化T细胞胞浆蛋白2抗体

hz-2669R phospho-NFATc2(Ser326)  磷酸化核因子活化T细胞胞浆蛋白2抗体

hz-5516R phospho-NFATc2(Ser330)  磷酸化核因子活化T细胞胞浆蛋白2抗体

hz-2400R NFBD1/MDC1  DNA损伤关卡蛋白1抗体

hz-0708R NF-H/Neurofilament H/Neurofilament 200  高分子量神经丝蛋白抗体

hz-3622R NFKB p52/NFKB2  细胞核因子/k基因结合核因子 p52/p100抗体

hz-3723R Phospho-NFKB2(Ser866+Ser870)  细胞核因子/k基因结合核因子p100抗体

hz-0465R NFKB p65  细胞核因子/k基因结合核因子抗体

hz-3543R Phospho-NFKB p65(Ser276)  磷酸化细胞核因子NF-κB p65抗体

hz-3485R Phospho-NFKB p65(Ser468)  磷酸化细胞核因子NF-κB p65抗体

hz-0982R phospho-NFKB p65(Ser536)  磷酸化细胞核因子抗体

hz-5660R phospho-NFKB p65(Ser529)  磷酸化细胞核因子抗体

hz-5661R phospho-NFKB p65(Thr435)  磷酸化细胞核因子抗体

hz-5662R phospho-NFKB p65(Thr254)  磷酸化细胞核因子抗体

hz-5663R phospho-NFKB p65(Thr505)  磷酸化细胞核因子抗体

hz-5664R SULT2A1  胆盐磺基转移酶

hz-4181R p53R2/RRM2B  核苷酸还原酶M2B抗体

hz-2408R NF66/alpha Internexin  α-中连蛋白抗体

hz-0707R NF-L/Neurofilament L/Neurofilament 68  低分子量神经丝蛋白抗体

hz-0710R NF-M/Neurofilament M  中分子量神经丝蛋白抗体

hz-1373R NGAL/Lipocalin 2  脂质运载蛋白抗体

hz-1194R NFkB p105/p50  细胞核因子p50/k基因结合核因子抗体

hz-3300R Phospho-NFκB-p105/p50(Ser927)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-3544R Phospho-NFKB1(Ser933)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-5509R Phospho-NFKB1(Ser903)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-5510R Phospho-NFKB1(Thr932)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-5511R Phospho-NFKB1(Ser907)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-5512R Phospho-NFKB1(Ser338)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-5513R Phospho-NFKB1(Ser893)  磷酸化细胞核因子p50/k基因结合核因子抗体

hz-6205R NFkB p100/p52  细胞核因子p100/p52k基因结合核因子抗体

hz-0161R NGFR/p75NTR  神经生长因子受体抗体

hz-0067R NGF-β  神经生长因子β抗体

hz-6731R SDCG1  血清学定义结肠癌抗原1抗体

hz-0922R NGN3/Neurogenin 3  神经元素3抗体

hz-1065R NGX6  鼻咽癌细胞相关基因6抗体

hz-0505R NHE1/APNH1  钠氢通道蛋白抗体