畸胎瘤癌基因RAS相关病毒抗体

英文名称    RRAS2    

中文名称    畸胎瘤癌基因RAS相关病毒抗体    

别    名    Oncogene RRAS2; Oncogene TC21; Ras like protein TC21; Ras related protein R Ras2; Related RAS viral (r ras) oncogene homolog 2; Related RAS viral oncogene homolog 2; RRAS 2; TC 21; TC21; Teratocarcinoma oncogene; Teratocarcinoma oncogene TC21; C86394; RRAS2_HUMAN; ras-related protein R-Ras2.    

畸胎瘤癌基因RAS相关病毒抗体        

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  免疫学  信号转导  G蛋白偶联受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    23kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RRAS2    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

畸胎瘤癌基因RAS相关病毒抗体产品介绍    background:
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Function:
It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine.

Tissue Specificity:
Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.

Post-translational modifications:
May be post-translationally modified by both palmitoylation and polyisoprenylation.

DISEASE:
Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.

Similarity:
Belongs to the small GTPase superfamily. Ras family.

Gene ID:
22800

Database links:

Entrez Gene: 22800 Human

Omim: 600098 Human

SwissProt: P62070 Human

Unigene: 502004 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

畸胎瘤癌基因RAS相关病毒抗体

hz-1882R M-RAS/Mras  原癌基因M-ras抗体

hz-3832R RHEB  Ras蛋白脑组织同源类似物RHEB蛋白抗体

hz-3503R Mre11/HNGS1  DNA损伤关键蛋白Mre11抗体

hz-3293R Phospho-Mre11 (Ser676)  磷酸化DNA损伤关键蛋白Mre11抗体

hz-1061R MPO/c-ANCA  髓过氧化物酶抗体

hz-1850R MCR/NR3C2/Mineralocorticoid receptor  盐皮质激素受体抗体

hz-0657R MRP1/ABCC1  多药耐药相关蛋白1抗体

hz-1092R MRP2  多药耐药相关蛋白2抗体

hz-0656R MRP3  多药耐药相关蛋白3抗体

hz-1422R MRP4/ABCC4  多药耐药相关蛋白4抗体

hz-1437R MRP5/ABCC5  多药耐药相关蛋白5抗体

hz-5761R MRP7/ABCC10  多药耐药相关蛋白7抗体

hz-5762R MRP8/ABCC11  多药耐药相关蛋白8抗体

hz-5763R MRP9/ABCC12  多药耐药相关蛋白9抗体

hz-3834R MrpL12  线粒体核糖体蛋白L12抗体

hz-0818R MrpL28  线粒体核糖体蛋白L28抗体

hz-1848R MSH Alpha  促黑细胞激素α抗体

hz-3910R MSH γ1  促黑细胞激素γ1抗体

hz-3918R MSH gamma  促黑细胞激素γ抗体

hz-3835R MrpL39  线粒体核糖体蛋白L39

hz-0758R MSH2  错配修复蛋白2抗体

hz-3804R MSH6  错配修复蛋白6抗体

hz-2995R MSK1/RPS6KA5  有丝分裂原和应激活化型蛋白激酶1抗体

hz-3281R Phospho-MSK1 (Ser360)  磷酸化有丝分裂原和应激活化型蛋白激酶1抗体

hz-3282R Phospho-MSK1 (Ser212)  磷酸化有丝分裂原和应激活化型蛋白激酶1抗体

hz-3283R Phospho-MSK1 (Ser376)  磷酸化有丝分裂原和应激活化型蛋白激酶1抗体

hz-3284R Phospho-MSK1(Thr581)  磷酸化有丝分裂原和应激活化型蛋白激酶1抗体

hz-3504R MST1  蛋白激酶MST抗体

hz-3294R Phospho-Mst1(Thr183)/Mst2(Thr180)  磷酸化蛋白激酶MST抗体

hz-4634R Phospho-Mst2(Thr180)  磷酸化蛋白激酶MST2抗体

hz-4635R Phospho-Mst1(Thr183)  磷酸化蛋白激酶MST1抗体

hz-5120R MSS1  26S蛋白酶调节亚型7抗体

hz-0836R MLH1/hMLH 1  错配修复蛋白1抗体

hz-0300R Mesothelin  间皮素抗体

hz-1022R MUC5AC/Mucin 5AC  胃粘液素抗体

hz-3601R MTF-1  金属应答元件结合转录因子-1抗体

hz-1484R MTHFR  亚甲基四氢叶酸还原酶MTHFR抗体

hz-0027R MTNR1A/MTR-1A/MEL-1A-R  褪黑素受体1A/松果体素受体1A抗体

hz-0963R MTNR1B  褪黑素受体1B抗体