癌基因RAS相关蛋白Rab25抗体

英文名称    Rab25    

中文名称    癌基因RAS相关蛋白Rab25抗体    

别    名    CATX 8; CATX-8; CATX8; member RAS oncogene family; RAB25; RAB-25; RAB25_HUMAN; Ras related protein Rab 25; Ras-related protein Rab-25.    

癌基因RAS相关蛋白Rab25抗体        

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  信号转导  转录调节因子  肿瘤细胞生物标志物  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    23kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Rab25 (145-190aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

癌基因RAS相关蛋白Rab25抗体产品介绍    background:
RAB proteins, such as RAB25, are members of the RASsuperfamily of small GTPases that are involved in membranetrafficking. Members of the RAB11 subfamily, including RAB25,control the return of internalized membrane-associated moieties tothe cell surface 

Function:
Involved in the regulation of cell survival. Promotesinvasive migration of cells in which it functions to localize andmaintain integrin alpha-V/beta-1 at the tips of extendingpseudopodia. Increases the rates of ovarian and breast cancersprogression and aggressiveness by modulating cellular processessuch as proliferation, survival and migration of epithelial tumorcells. May selectively regulate the apical recycling pathway.Together with MYO5B regulates transcytosis

Subunit:
Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 andRAB11FIP4. Interacts (via the hypervariable C-terminal region) withITGB1 (via the cytoplasmic region); the interaction isGTP-dependent. Interacts with ITGAV. Associates with the integrinalpha-V/beta-1 heterodimer.

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmicside (Potential). Cell projection, pseudopodium membrane.Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1in vesicles at the pseudopodial tips.

Tissue Specificity:
Expressed in ovarian epithelium (NOE) andbreast tissue. Expressed in ovarian cancer; expression is increasedrelative to NOE cells. Expression in ovarian cancer is stagedependent, with stage III and stage IV showing higher levels thanearly stage cancers. Expressed in breast cancer; expression isincreased relative to normal breast tissue.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

癌基因RAS相关蛋白Rab25抗体

hz-2726R TPSB2  肥大细胞类胰蛋白酶β2

hz-1419R MC-1R  黑皮质素-1受体抗体

hz-2755R MCSF Receptor  巨噬细胞集落刺激因子受体抗体

hz-1042R MCSF/M-CSF  巨噬细胞克隆刺激因子抗体

hz-3074R phospho-M-CSF Receptor(Tyr546)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-3075R phospho CSF1R (Tyr699)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-3076R phospho-M-CSF Receptor(Tyr708)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-3077R phospho-CSF1R (Tyr723)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-3078R phospho-M-CSF Receptor(Tyr809)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-3079R phospho-CSF1R(Tyr923)  磷酸化巨噬细胞集落刺激因子受体抗体

hz-1569R MCT1  单羧酸转运蛋白-1抗体

hz-1981R MCM2  微小染色体维持缺陷蛋白2抗体

hz-1982R MCM3  微小染色体维持缺陷蛋白3抗体

hz-2721R MCM5  微小染色体维持缺陷蛋白5抗体

hz-1983R MCM7  微小染色体维持缺陷蛋白7抗体

hz-1352R Mcl1/BCL2L3  髓样分化蛋白2抗体

hz-3265R Phospho-Mcl1 (Ser159/Thr163)  磷酸化髓样细胞白血病-1抗体

hz-3996R MDH1  可溶性苹果酸脱氢酶抗体

hz-1043R MDM2  双微体2癌基因抗体

hz-3266R Phospho-MDM2 (Ser166)  磷酸化双微体2癌基因抗体

hz-5470R Phospho-MDM2(Thr218)  磷酸化双微体2癌基因抗体

hz-5471R Phospho-MDM2(Ser186)  磷酸化双微体2癌基因抗体

hz-1468R MDR1/p-GP/CD243 (C-terminus)  多药耐药蛋白/P-糖蛋白抗体(C端)

hz-0563R MDR1/p-GP/CD243 (N-terminus)  多药耐药蛋白/P-糖蛋白抗体

hz-5915R MBD1/PCM1  甲基化CpG结合蛋白抗体

hz-3823R MeCP2  甲基化CpG结合蛋白2抗体

hz-1400R MEF2A  肌细胞增强因子2抗体

hz-3267R Phospho-MEF2A (Thr312)  磷酸化肌细胞增强因子2抗体

hz-3268R Phospho-MEF2A (Ser408)  磷酸化肌细胞增强因子2抗体

hz-4130R MEF2C  肌细胞增强因子2C抗体

hz-5479R phospho-MEF2C(Ser59)  磷酸化肌细胞增强因子2C抗体

hz-5480R phospho-MEF2C(Ser396)  磷酸化肌细胞增强因子2C抗体

hz-5485R Phospho-MEF2A(Thr319)  磷酸化肌细胞增强因子2抗体

hz-5481R phospho-MEF2C(Ser387)  磷酸化肌细胞增强因子2C抗体

hz-5482R phospho-MEF2C(Thr20)  磷酸化肌细胞增强因子2C抗体

hz-5483R phospho-MEF2C(Thr300)  磷酸化肌细胞增强因子2C抗体

hz-0815R Megsin  丝氨酸蛋白酶抑制剂B7抗体

hz-4136R MEF2D  肌细胞特异性增强因子2D抗体