泛素结合蛋白P62抗体

英文名称    SQSTM1    

中文名称    泛素结合蛋白P62抗体    

别    名    A170; EBI 3 associated protein of 60 kDa; EBI3 associated protein of 60 kDa; EBI3-associated protein of 60 kDa; EBIAP; MGC127197; ORCA; OSF-6; Osi; OSIL; Oxidative stress induced like; p60; p62; p62B; Paget disease of bone 3; PDB 3; PDB3; Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa; Phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; PKC-zeta-interacting protein; Protein kinase C-zeta-interacting protein; Sequestosome 1; Sequestosome-1; SQSTM 1; SQSTM_HUMAN; Sqstm1; STAP; STONE14; Ubiquitin binding protein p62; Ubiquitin-binding protein p62; ZIP 3; ZIP; ZIP3    

 泛素结合蛋白P62抗体 

说 明 书    0.1ml  0.2ml      

研究领域    心血管  染色质和核信号  信号转导  细胞凋亡  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    48kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human SQSTM1/p62    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

 泛素结合蛋白P62抗体 产品介绍    background:
Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

Function:
Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.

Subunit:
Cytoplasm. Late endosome. Nucleus. Endoplasmic reticulum. Note=Sarcomere. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum.

Subcellular Location:
Cytoplasm. Late endosome. Nucleus. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.

Tissue Specificity:
Ubiquitously expressed.

Post-translational modifications:
Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN.

DISEASE:
Defects in SQSTM1 are a cause of Paget disease of bone (PDB) [MIM:602080]. PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma. PDB is a chronic disease affecting 2 to 3% of the population above the age of 40 years.

Similarity:
Contains 1 OPR domain.
Contains 1 UBA domain.
Contains 1 ZZ-type zinc finger. 

Database links:

Entrez Gene: 8878 Human

Entrez Gene: 18412 Mouse

Entrez Gene: 113894 Rat

Omim: 601530 Human

SwissProt: Q13501 Human

SwissProt: Q64337 Mouse

SwissProt: O08623 Rat

Unigene: 709030 Human

Unigene: 40828 Mouse

Unigene: 107103 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

 泛素结合蛋白P62抗体 

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hz-1425R MAP3K5/ASK1/MEKK5  细胞凋亡信号调节激酶1抗体

hz-3007R phospho-ASK1 (Ser966)  磷酸化细胞凋亡信号调节激酶1抗体

hz-3029R phospho-ASK1(Ser967)  磷酸化细胞凋亡信号调节激酶1抗体

hz-3031R phospho-ASK1(Thr845)  磷酸化细胞凋亡信号调节激酶1抗体

hz-5436R phospho-ASK1(Ser83)  磷酸化细胞凋亡信号调节激酶1抗体

hz-5437R phospho-ASK1(Ser1033)  磷酸化细胞凋亡信号调节激酶1抗体

hz-4123R phospho-MEK3(Thr222)  磷酸化丝裂原活化蛋白激酶激酶3抗体

hz-0792R Maspin  抑癌基因抗体

hz-1723R MASP  甘露聚糖结合凝集素丝氨酸肽酶1抗体

hz-4693R MAL  MAL蛋白抗体

hz-1980R MASP2  甘露聚糖结合凝集素丝氨酸肽酶2抗体

hz-0531R Matriptase  蛋白裂解酶（一种新的癌基因）抗体

hz-6130R RbAp48  视网膜母细胞瘤结合蛋白P48抗体

hz-0380R MBP  髓鞘碱性蛋白（磷脂碱性蛋白）抗体

hz-6131R FAM123B/AMER1/Wilms tumor on the X  肾母细胞瘤基因X染色体蛋白抗体

hz-5474R phospho-MBP(Thr232)  磷酸化髓鞘碱性蛋白抗体

hz-0271R Cytomegalovirus pp65   巨细胞病毒PP65/CMV低基质磷脂蛋白抗体

hz-5475R phospho-MBP(Tyr203)  磷酸化髓鞘碱性蛋白抗体

hz-2271R HCMV  人巨细胞病毒抗体

hz-0896R HCMV UL23  人巨细胞病毒UL23抗体

hz-0808R HCMV UL49  人巨细胞病毒UL49蛋白抗体

hz-2274R HCMV UL49  人巨细胞病毒UL49蛋白抗体

hz-4205R hnRNP F  异质核糖核蛋白F抗体

hz-4300R hnRNP L  异质核糖核蛋白L抗体

hz-6134R WNT4  信号通路Wnt4抗体

hz-6135R Wnt6  信号通路Wnt6抗体

hz-6136R Adenovirus 5 E1A  腺病毒早期E1A蛋白抗体

hz-1101R MCP1/CCL2  单核细胞趋化蛋白1抗体

hz-1955R MCP1/CCL2  单核细胞趋化蛋白1抗体

hz-1984R MCP-2/CCL8  单核细胞趋化蛋白2抗体

hz-1985R MCP-2/CCL8  单核细胞趋化蛋白2抗体(小鼠)

hz-1986R MCP-3/CCL7  单核细胞趋化蛋白3抗体

hz-1987R MCP-3/CCL7  单核细胞趋化蛋白3抗体

hz-2477R CCL9/CCL10/MIP-1 gamma/SCYA10  巨噬细胞炎症蛋白-1γ抗体

hz-2725R Mast Cell Tryptase  肥大细胞蛋白酶7抗体