ATP调节钾离子通道ROM K抗体

英文名称    ROM-K/Kcnj1    

中文名称    ATP调节钾离子通道ROM K抗体    

别    名    ROM K; ROM-K; inwardly rectifying subfamily J member 1; ATP regulated potassium channel ROM K; ATP sensitive inward rectifier potassium channel 1; ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; Inward rectifier K(+) channel Kir1.1; inwardly rectifying K+ channel; IRK1_HUMAN; KCNJ 1; KCNJ; Kcnj1; Kir 1.1; Kir1.1; Potassium channel; Potassium channel inwardly rectifying subfamily J member 1; potassium inwardly-rectifying channel J1; ROMK 1; ROMK 2; ROMK; ROMK1; ROMK2.    

ATP调节钾离子通道ROM K抗体      

说 明 书    0.2ml      

研究领域    细胞生物  信号转导  通道蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    45kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human ROM-K/KCNJ1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

ATP调节钾离子通道ROM K抗体产品介绍    background:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 

Function:
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.

Subunit:
Interacts with SGK1 and SLC9A3R2/NHERF2. 

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.

Post-translational modifications:
Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. 

DISEASE:
Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) [MIM:241200]; also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.

Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily.

Database links:
UniProtKB/Swiss-Prot: P48048.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutATP调节钾离子通道ROM K抗体ic or diagnostic applications.    

hz-1804R Integrin alpha L/CD11a  整合素αL抗体

hz-1014R CD11b/Integrin αM/Integrin Alpha M  整合素αM/巨噬细胞表面分子抗体

hz-2508R Integrin Alpha X/CD11c  整合素αX抗体

hz-2659R MARCO  巨噬细胞清道夫受体抗体

hz-6023R BST1/CD157  骨髓基质干细胞抗原1抗体

hz-2909R MARCKS  丙氨酸蛋白激酶C底物Marcks抗体

hz-3263R Phospho-MARCKS (Ser152/156)  磷酸化丙氨酸蛋白激酶C底物Marcks抗体

hz-3359R Phospho-MARCKS (Ser162)  磷酸化丙氨酸蛋白激酶C底物Marcks抗体

hz-5500R Phospho-MARCKS(Ser170)  磷酸化丙氨酸蛋白激酶C底物Marcks抗体

hz-1595R MAD1  Mad1抗体

hz-0642R MAdCAM-1  粘膜血管定居因子抗体

hz-3859R MAGP2  纤微丝相关糖蛋白2抗体

hz-1975R DAXX  死亡相关蛋白6抗体(Fas死亡区相关蛋白)

hz-3135R Phospho-FADD(Ser191)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5288R phospho-DAXX (Ser213)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5291R phospho-DAXX (Ser495)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5292R phospho-DAXX (Ser517)  磷酸化Fas相关死亡结构域蛋白抗体

hz-5293R phospho-DAXX (Ser671)  磷酸化Fas相关死亡结构域蛋白抗体

hz-0924R Mafa  v-maf 肌腱膜纤维肉瘤癌基因同源物A抗体

hz-2591R MAFbx/Fbx32  泛素蛋白连接酶抗体

hz-0257R MAG-a/b  髓鞘相关糖蛋白a/b抗体

hz-0258R MAG-a/L-MAG  髓鞘相关糖蛋白-a抗体

hz-0817R MAGE-1  黑色素瘤相关抗原抗体

hz-3645R MAGE-A4  黑色素瘤相关抗原4抗体

hz-3802R Mammaglobin A  乳腺珠蛋白1抗体

hz-3803R Mammaglobin B  乳腺珠蛋白2抗体

hz-2931R Mammaglobin A  乳腺珠蛋白1抗体

hzm-2028M Marijuana(2B1)  小鼠抗大麻单克隆抗体

hz-4053R MAVS  线粒体抗病毒信号MAVS蛋白抗体

hz-2340R 14-3-3E/YWHAE  14-3-3E蛋白抗体

hz-2076R Methamphetamine  甲基苯丙胺抗体

hzm-2068M Methamphetamine(4D2)  甲基苯丙胺单克隆抗体

hz-5141R MATR3/Matrin 3  核基质蛋白3抗体

hz-3636R MO25 alpha/CAB39  钙结合蛋白39抗体

hz-4054R Methionine adenosyltransferase  蛋氨酸腺苷转移酶抗体

hz-5590R phospho-YWHAE(Thr232)  磷酸化14-3-3E蛋白抗体

hz-2884R Mesothelioma  间质细胞蛋白抗体

hz-5084R ME1  胞浆苹果酸酶1抗体