视网膜母细胞瘤结合蛋白6抗体

英文名称    RBBP6    

中文名称    视网膜母细胞瘤结合蛋白6抗体    

别    名    Retinoblastoma binding protein 6; RBBP6; MY038; P2P R; P2PR; p53 associated cellular protein of testis; PACT;Proliferationpotentialrelated protein; Protein P2P R; Protein P2PR; Protein RBQ 1; Protein RBQ1; RB binding Q protein 1; RBBP 6; RBQ 1; RBQ1; Retinoblastoma binding protein 6 isoform 3; Retinoblastoma binding Q protein 1; SNAMA; RBBP6_HUMAN.    

视网膜母细胞瘤结合蛋白6抗体         

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  细胞凋亡  细胞周期蛋白  肿瘤细胞生物标志物      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    201kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RBBP6 (1265-1315aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

视网膜母细胞瘤结合蛋白6抗体  产品介绍    background:
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. Retinoblastoma binding protein 6 binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.

Function:
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.

Subunit:
Interacts with p53/TP53 and RB1 (By similarity). Interacts also with MDM2 and YBX1. Interacts with NEK6.

Subcellular Location:
ucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome.

Tissue Specificity:
Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by NEK6. 

Similarity:
Contains 1 CCHC-type zinc finger. 
Contains 1 DWNN domain. 
Contains 1 RING-type zinc finger. 

Database links:
UniProtKB/Swiss-Prot: Q7Z6E9.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

视网膜母细胞瘤结合蛋白6抗体  

hz-4019R CYP5A1/Thromboxane synthase  血栓素合成酶抗体

hz-5055R CYP4A22  细胞色素P4504A22抗体（脂肪酸Ω羟化酶）

hz-2399R CYP7A1  细胞色素P450 7A1抗体/胆固醇7a羟化酶

hz-2991R CYP2D6  细胞色素P450 2D6抗体

hz-2352R Cytochrome P450 2B6  细胞色素P450 2B6抗体

hz-3853R CYP17  细胞色素P450 17抗体

hz-1292R CYP19/CYP19A1  细胞色素P450 19抗体

hz-5052R CYP7B1  胆固醇25α7羟化酶抗体

hz-3677R CYP8A1/PTGIS  前列环素合成酶抗体

hz-2443R CYP21  胆固醇21-羟化酶抗体

hz-2795R CYP2C19  细胞色素P450 2C19抗体

hz-3899R CYP24A1  细胞色素P450 24A1抗体

hz-5049R CYP27A1  胆固醇27α羟化酶抗体

hz-0461R CYP450  细胞色素P450单氧化酶抗体

hz-5816R RRAGA  RAS相关GTP结合蛋白A抗体

hz-1290R Cyr61/IGFBP10/CCN1  富半胱氨酸肝素结合蛋白61抗体

hz-1725R CYP2E1  细胞色素P450ⅡE1抗体

hz-4562R CYP2E1  细胞色素P450ⅡE1抗体

hz-3900R CYP2R1  细胞色素P450 2R1抗体

hz-5046R CYP46  胆固醇24S－羟化酶

hz-5050R CYP39A1  胆固醇24α7羟化酶抗体

hz-5051R CYP46  胆固醇24羟化酶抗体

hz-5819R TMhz161A  跨膜蛋白161A抗体

hz-0013R Cytochrome C  细胞色素C抗体

hz-5820R USP28  泛素特异性蛋白酶28抗体

hz-3879R p22-phox/Cytochrome b245 Light Chain  细胞色素b245轻链抗体

hz-5821R Desmoglein 2  桥粒芯糖蛋白2抗体

hz-5824R Cadherin like 23  钙粘蛋白23抗体

hz-4099R DAAM1  形态发生紊乱关联激活因子1抗体

hz-5303R phospho-DAAM1 (Thr361)  磷酸化形态发生紊乱关联激活因子1抗体

hz-3114R Phospho-Dab1 (Tyr220)  磷酸化Disabled 1抗体

hz-3115R Phospho-Dab1 (Tyr232)  磷酸化Disabled 1抗体

hz-3116R Phospho-Dab1 (Ser491)  磷酸化Disabled 1抗体

hz-3659R DACH2  转录调节因子DACH2抗体

hz-2762R DARPP32  多巴胺、cAMP调节磷蛋白抗体