英文名称 RBBP6
中文名称 视网膜母细胞瘤结合蛋白6抗体
别 名 Retinoblastoma binding protein 6; RBBP6; MY038; P2P R; P2PR; p53 associated cellular protein of testis; PACT;Proliferationpotentialrelated protein; Protein P2P R; Protein P2PR; Protein RBQ 1; Protein RBQ1; RB binding Q protein 1; RBBP 6; RBQ 1; RBQ1; Retinoblastoma binding protein 6 isoform 3; Retinoblastoma binding Q protein 1; SNAMA; RBBP6_HUMAN.
视网膜母细胞瘤结合蛋白6抗体
说 明 书 0.1ml 0.2ml
研究领域 肿瘤 细胞生物 细胞凋亡 细胞周期蛋白 肿瘤细胞生物标志物
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 201kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RBBP6 (1265-1315aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
视网膜母细胞瘤结合蛋白6抗体 产品介绍 background:
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. Retinoblastoma binding protein 6 binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.
Function:
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
Subunit:
Interacts with p53/TP53 and RB1 (By similarity). Interacts also with MDM2 and YBX1. Interacts with NEK6.
Subcellular Location:
ucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome.
Tissue Specificity:
Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by NEK6.
Similarity:
Contains 1 CCHC-type zinc finger.
Contains 1 DWNN domain.
Contains 1 RING-type zinc finger.
Database links:
UniProtKB/Swiss-Prot: Q7Z6E9.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
视网膜母细胞瘤结合蛋白6抗体
hz-4019R CYP5A1/Thromboxane synthase 血栓素合成酶抗体
hz-5055R CYP4A22 细胞色素P4504A22抗体(脂肪酸Ω羟化酶)
hz-2399R CYP7A1 细胞色素P450 7A1抗体/胆固醇7a羟化酶
hz-2991R CYP2D6 细胞色素P450 2D6抗体
hz-2352R Cytochrome P450 2B6 细胞色素P450 2B6抗体
hz-3853R CYP17 细胞色素P450 17抗体
hz-1292R CYP19/CYP19A1 细胞色素P450 19抗体
hz-5052R CYP7B1 胆固醇25α7羟化酶抗体
hz-3677R CYP8A1/PTGIS 前列环素合成酶抗体
hz-2443R CYP21 胆固醇21-羟化酶抗体
hz-2795R CYP2C19 细胞色素P450 2C19抗体
hz-3899R CYP24A1 细胞色素P450 24A1抗体
hz-5049R CYP27A1 胆固醇27α羟化酶抗体
hz-0461R CYP450 细胞色素P450单氧化酶抗体
hz-5816R RRAGA RAS相关GTP结合蛋白A抗体
hz-1290R Cyr61/IGFBP10/CCN1 富半胱氨酸肝素结合蛋白61抗体
hz-1725R CYP2E1 细胞色素P450ⅡE1抗体
hz-4562R CYP2E1 细胞色素P450ⅡE1抗体
hz-3900R CYP2R1 细胞色素P450 2R1抗体
hz-5046R CYP46 胆固醇24S-羟化酶
hz-5050R CYP39A1 胆固醇24α7羟化酶抗体
hz-5051R CYP46 胆固醇24羟化酶抗体
hz-5819R TMhz161A 跨膜蛋白161A抗体
hz-0013R Cytochrome C 细胞色素C抗体
hz-5820R USP28 泛素特异性蛋白酶28抗体
hz-3879R p22-phox/Cytochrome b245 Light Chain 细胞色素b245轻链抗体
hz-5821R Desmoglein 2 桥粒芯糖蛋白2抗体
hz-5824R Cadherin like 23 钙粘蛋白23抗体
hz-4099R DAAM1 形态发生紊乱关联激活因子1抗体
hz-5303R phospho-DAAM1 (Thr361) 磷酸化形态发生紊乱关联激活因子1抗体
hz-3114R Phospho-Dab1 (Tyr220) 磷酸化Disabled 1抗体
hz-3115R Phospho-Dab1 (Tyr232) 磷酸化Disabled 1抗体
hz-3116R Phospho-Dab1 (Ser491) 磷酸化Disabled 1抗体
hz-3659R DACH2 转录调节因子DACH2抗体
hz-2762R DARPP32 多巴胺、cAMP调节磷蛋白抗体