核糖体蛋白L5抗体

英文名称    RPL5    

中文名称    核糖体蛋白L5抗体    

别    名    60S ribosomal protein L5; MSTP030; Ribosomal protein L5; RL5; RL5_HUMAN; RP L5; RPL 5; RPL5; U21 RNA; U21RNA.    

核糖体蛋白L5抗体        

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  神经生物学  肿瘤细胞生物标志物      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    34kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RPL5 (132-180aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

核糖体蛋白L5抗体产品介绍    background:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Function:
Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.

Subcellular Location:
Cytoplasm. Nucleus

DISEASE:
Defects in RPL5 are the cause of Diamond-Blackfan anemia type 6 (DBA6) . DBA6 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.

Similarity:
Belongs to the ribosomal protein L18P family.

Database links:
UniProtKB/Swiss-Prot: P46777.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

核糖体蛋白L5抗体

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hz-4211R Cullin 3  Cullin3抗体

hz-1715R Connexin-26  间隙连接蛋白26抗体

hz-4209R Cullin 2  Cullin2抗体

hz-2383R Connexin-31  间隙连接蛋白31抗体

hz-1376R Connexin-32  间隙连接蛋白32抗体

hz-1266R Connexin-36  间隙连接蛋白36抗体

hz-4067R Connexin-37/GJA4  间隙连接蛋白37抗体

hz-1050R Connexin-40  间隙连接蛋白40抗体

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