环指蛋白5抗体（E3泛素蛋白连接酶RNF5）

英文名称    RING5    

中文名称    环指蛋白5抗体（E3泛素蛋白连接酶RNF5）    

别    名    E3 ubiquitin protein ligase RNF5; G16; HsRma1; NG2; OTTHUMP00000029107; Protein G16; Ring finger; protein 5; RING5; RMA1; RNF 5; RNF5_HUMAN.    

环指蛋白5抗体（E3泛素蛋白连接酶RNF5）         

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  肿瘤细胞生物标志物      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    20kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RING5 (51-100aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

环指蛋白5抗体（E3泛素蛋白连接酶RNF5） 产品介绍    background:
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions.

Function:
Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Subunit:
Interacts with PXN. Interacts with Salmonella typhimurium sopA. Interacts with JKAMP. Interacts with TMEM173; the interaction of endogenous proteins is dependent on viral infection. 

Subcellular Location:
Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.

Tissue Specificity:
Widely expressed.

Similarity:
Contains 1 RING-type zinc finger.

Database links:
UniProtKB/Swiss-Prot: Q99942.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

环指蛋白5抗体（E3泛素蛋白连接酶RNF5） 

hz-1733R phospho C-Met/HGFR(Tyr1365)  磷酸化原癌基因c-Met抗体

hz-0842R c-Myc tag  c-Myc tag标签抗体

hz-2113R AU5 tag  AU5 tag标签抗体

hz-2114R AU1 tag  AU1 tag标签抗体

hz-2115R Glu-Glu Tag  Glu-Glu tag抗体

hz-2116R E Tag  E Tag标签抗体

hz-2074R CNGA2  环核苷酸阳离子通道蛋白α2抗体

hz-1693R CANX/Calnexin  钙连蛋白抗体

hz-5757R FAM13B1  FAM13B1蛋白抗体

hz-1000R CNP/CNPase  C型钠尿肽抗体

hz-1683R CNR1/CB1  钙粘蛋白相关的神经受体1抗体

hz-2377R CNR2/CB2  钙粘蛋白相关的神经受体2抗体

hz-1516R CNTFR-α  睫状神经营养因子受体α抗体

hz-1711R CNR-2/PCDHA6  钙粘蛋白相关的神经受体2抗体

hz-1272R CNTF  睫状神经营养因子抗体

hz-3099R Phospho-Cofilin(Ser3)  磷酸化丝切蛋白抗体

hz-5258R Phospho-Cofilin/CFL1 (Tyr139)  磷酸化丝切蛋白抗体

hz-5259R phospho-CFL1/CFL2 (Tyr88)  磷酸化丝切蛋白抗体

hz-2541R COLEC12  凝集胎盘蛋白1抗体

hz-0578R Collagen I  Ⅰ型胶原抗体

hz-0709R Collagen II/Chondrocalcin  Ⅱ型胶原α1蛋白/软骨钙素抗体

hz-5758R FAP/FAPA  成纤维细胞激活蛋白α抗体

hz-5760R FAP1/PTPN13  Fas相关磷酸酶1/蛋白酪氨酸磷酸酶非受体型13抗体

hz-0549R Collagen III  抗Ⅲ型胶原抗体 Collagen Ⅲ

hz-0948R Collagen III  抗Ⅲ型胶原抗体

hz-5764R CIAPIN1  细胞因子诱导凋亡抑制因子1

hz-0806R Collagen IV/Arresten  抗IV型胶原抗体

hz-0552R Collagen V  Ⅴ型胶原抗体

hz-4595R Collagen IV  抗IV型胶原抗体

hz-0553R Collagen VI alpha 1  抗Ⅵ型胶原抗体

hz-5765R LANCL2  G蛋白偶联受体69B

hz-1558R Collagen VII  7型胶原抗体

hz-5766R RAB6C  RAS癌基因相关蛋白Rab6C抗体

hz-5767R Epigen  上皮细胞有丝分裂蛋白抗体

hz-2921R PAR3  非典型蛋白激酶C特定相互作用蛋白抗体

hz-0554R Collagen X  Ⅹ型胶原抗体

hz-5044R COL4A3BP  IV型胶原α3结合蛋白抗体

hz-2924R Collagen XI alpha 2  胶原蛋白11A2抗体

hz-1428R Claudin 1  紧密连接蛋白1抗体

hz-2788R Claudin 3  紧密连接蛋白3抗体

hz-2790R Claudin 4  紧密连接蛋白4抗体

hz-2760R Cortactin  皮层肌动蛋白抗体

hz-3100R phospho-Cortactin (Tyr466)  磷酸化皮层肌动蛋白抗体