RAS家族关联结构域蛋白7抗体

英文名称    RASSF7    

中文名称    RAS家族关联结构域蛋白7抗体    

别    名    C11orf13; Chromosome 11 open reading frame 13; HRAS1; HRAS1 related cluster 1; HRAS1 related cluster protein 1; HRC1; MGC126069; Ras association (RalGDS/AF 6) domain family (N terminal) member 7; Ras association (RalGDS/AF 6) domain family 7; Ras association domain containing protein 7; RASSF 7; RASF7_HUMAN.    

 RAS家族关联结构域蛋白7抗体      

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  细胞周期蛋白  细胞分化  细胞类型标志物  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    40kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RASSF7    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

 RAS家族关联结构域蛋白7抗体 产品介绍    background:
RASSF7 contains 1 Ras-associating domain. It is a centrosome-associated protein required to form a spindle and complete mitosis in the neural tube. There are two isoforms.

Function:
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. 

Subunit:
Interacts with MAP2K7 and GTP-bound NRAS.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with gamma-tubulin. 

Post-translational modifications:
Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli. 

Similarity:
Contains 1 Ras-associating domain. 

Database links:
UniProtKB/Swiss-Prot: Q02833.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

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