RIT1蛋白抗体

英文名称    RIT1    

中文名称    RIT1蛋白抗体    

别    名    GTP binding protein Roc1; GTP-binding protein Rit1; Ras like protein expressed in many tissues; Ras like without CAAX 1; Ras-like protein expressed in many tissues; Ras-like without CAAX protein 1; RIBB; Ric like expressed in many tissues; RIT; RIT1; RIT1_HUMAN; ROC1.    

RIT1蛋白抗体        

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  免疫学  神经生物学  信号转导  G蛋白偶联受体  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    25kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RIT1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

RIT1蛋白抗体产品介绍    background:
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.
Neuronal activity dramatically increases the concentration of cytosolic Ca2+, which then serves as a second messenger to direct diverse cellular responses. Calmodulin is a primary mediator of Ca2+ signals in the nervous system. Ric, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin. In addition, two Ras-like human proteins, Rin and Rit (Ric-related gene expressed in many tissues), which are 71% and 66% identical to RIC respectively, share related G2 domains with Ric. While most members of the Ras subfamily are plasma membrane-associated and generally require a C-terminal isoprenyl group to bind to the plasma membrane, Rit and Rin lack the recognition signal for C-terminal prenylation. Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a C-terminal cluster of basic amino acids, which provides a mechanism for membrane association. Rin binds calmodulin through a C-terminal binding motif. Rit and Ric are widely expressed, whereas expression of Rin is restricted to the neuron system. In conclusion, Rit and Rin define a novel subfamily of Ras-related proteins

Function:
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.

Subunit:
Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state. Interacts with RGL3 (By similarity).

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed in many tissues.

Similarity:
Belongs to the small GTPase superfamily. Ras family. 

Database links:
UniProtKB/Swiss-Prot: Q92963.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

RIT1蛋白抗体

hz-5561R phospho-PRKD1(Ser738)  磷酸化蛋白激酶C mu型抗体

hz-8660R Salmonella typhimurium O  伤寒沙门氏菌体蛋白O抗原抗体

hz-8662R BASP1/Nap22  脑富含膜附着信号蛋白1抗体

hz-8670R Salmonella enteritidis H  伤寒沙门氏菌鞭毛抗原H抗体

hz-5562R phospho-PRKD1(Ser742)  磷酸化蛋白激酶C mu型抗体

hz-8671R MMS19  DNA修复甲基磺酸敏感性基因19抗体

hz-8672R HDL/high density lipoprotein  高密度脂蛋白抗体

hz-8673R KCTD12  钾离子通道多聚体结构域蛋白12抗体

hz-8675R BDKRB1  缓激肽B1受体抗体

hz-5563R phospho-PRKD1(Tyr463)  磷酸化蛋白激酶C mu型抗体

hz-8683R IGF2BP1/IMP1  胰岛素样生长因子ⅡmRNA结合蛋白1抗体

hz-8686R BRMS1  乳腺癌转移抑制基因1抗体

hz-8687R p53 (FL-393)  肿瘤抑制基因p53抗体

hz-8689R MEPE  细胞外基质磷酸化抗体

hz-8690R IFI44  干扰素诱导蛋白44抗体

hz-8691R KCNAB1/Kv beta 1  电压门控钾通道蛋白1抗体

hz-0576R Annexin II/Annexin A2  膜粘连蛋白 Ⅱ抗体

hz-4157R PRKD3  蛋白激酶C nu型抗体

hz-5564R phospho-PRKD3(Ser41)  磷酸化蛋白激酶C nu型抗体

hz-8717R SLC30A3/ZNT3  溶质载体锌转运3抗体

hz-8718R Viperin/RSAD2  病毒抑制蛋白Viperin抗体

hz-1631R Annexin Ⅲ  膜粘连蛋白A3抗体

hz-1564R Annexin IV  膜粘连蛋白 A4抗体

hz-8726R BZW2  BZW2蛋白抗体

hz-8729R TPH2  5色氨酸羟化酶2抗体

hz-0398R Annexin V  膜粘连蛋白5抗体

hz-5916R Annexin A9  膜粘连蛋白9抗体

hz-5127R Annexin A10/14  膜粘连蛋白10抗体

hz-1471R Annexin VI  膜粘连蛋白6抗体

hz-5917R Annexin A7  膜粘连蛋白7抗体

hz-4161R PRKCQ/PKC theta  蛋白激酶C theta抗体

hz-5583R phospho-PRKCQ(Ser676)  磷酸化蛋白激酶C theta抗体

hz-5584R phospho-PRKCQ(Ser695)  磷酸化蛋白激酶C theta抗体

hz-5585R phospho-PRKCQ(Thr538)  磷酸化蛋白激酶C theta抗体

hz-0450R Annexin V  重组膜粘连蛋白5抗体

hz-4166R YES1  原癌基因酪氨酸蛋白激酶Yes1抗体

hz-5591R phospho-YES1(Tyr426)  磷酸化原癌基因酪氨酸蛋白激酶Yes1抗体

hz-5592R phospho-YES1(Tyr537)  磷酸化原癌基因酪氨酸蛋白激酶Yes1抗体

hz-0934R Anthrax  炭疽杆菌抗体

hz-0935R Anthrax  炭疽菌抗体（采用活疫苗制备）

hz-9001R SARM1  SARM1蛋白抗体

hz-9002R SAMD9  SAMD9蛋白抗体

hz-9003R SAMD7  SAMD7蛋白抗体

hz-9004R SAMD3  SAMD3蛋白抗体

hz-9005R CECR1/ADGF  猫眼综合征染色体候选基因1抗体

hz-9006R CECR6  猫眼综合征染色体候选基因6抗体

hz-9007R RCBTB1/CLLD7  鸟嘌呤核苷酸交换因子抗体

hz-9008R CLRN3/TMhz12  跨膜蛋白12抗体

hz-9009R Transportin 1  转运蛋白1抗体

hz-9010R DPP6  二肽基肽酶6抗体

hz-9011R EFHA1  EFHA1蛋白抗体

hz-9012R SENP1  小泛素相关修饰蛋白1抗体

hz-9013R EFHC1  EFHC1蛋白抗体

hz-9014R EFHC2  EFHC2蛋白抗体