英文名称 RNF111
中文名称 环指蛋白111抗体
别 名 ARK; Arkadia; DKFZp313E0731; DKFZp686H1966; DKFZp761D081; E3 ubiquitin protein ligase Arkadia; FLJ38008; Ring finger protein 111; RNF 111; RN111_HUMAN.
环指蛋白111抗体
说 明 书 0.2ml
研究领域 细胞生物 免疫学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 109kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RNF111
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
环指蛋白111抗体 产品介绍 background:
RNF111 (Ring finger protein 111) acts in the NODAL pathway of mesoderm patterning during embryonic development. It is an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. It also induces degradation of the transriptional repressors SnoN and c-Ski. RNF111, therefore, effectively enhances TGF-beta signaling through simultaneous down-regulation of two distinct types of negative regulators, Smad7 and SnoN/c-Ski.
Function:
Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
Subunit:
Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1 and SMAD7. Interacts (via SIM domains) with SUMO1 and SUMO2.
Subcellular Location:
Cytoplasmic and Nuclear
Tissue Specificity:
Broadly expressed.
Similarity:
Contains 1 RING-type zinc finger.
Gene ID:
54778
Database links:
Entrez Gene: 54778 Human
Omim: 605840 Human
SwissProt: Q6ZNA4 Human
Unigene: 404423 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白111抗体
hz-8206R FAM82A1/RMD2 微管动力调节蛋白2抗体
hz-8208R FAM50A FAM50A蛋白抗体
hz-8209R FAM98B FAM98B蛋白抗体
hz-8210R FAM91A1 FAM91A1蛋白抗体
hz-4147R ODF2/Cenexin1 精子尾部结构蛋白抗体
hz-8211R FAM84B/BCMP101 乳腺癌膜相关蛋白101抗体
hz-8212R TEF4/TEA domain family mhzber 2 转录增强因子TEF4抗体
hz-8213R FAM113A FAM113A蛋白抗体
hz-8214R FAM21C FAM21C蛋白抗体
hz-8215R FAM13C1 FAM13C1蛋白抗体
hz-8216R FAM161A FAM161A蛋白抗体
hz-8217R FAM59B FAM59B蛋白抗体
hz-8218R FAM59A FAM59A蛋白抗体
hz-8219R FAM150A FAM150A蛋白抗体
hz-8220R FAM151A FAM151A蛋白抗体
hz-5530R phospho-ODF2(Ser796) 磷酸化精子尾部结构蛋白抗体
hz-8221R FAM153B FAM153B蛋白抗体
hz-8222R FAM154A FAM154A蛋白抗体
hz-8223R FAM155A FAM155A蛋白抗体
hz-8224R FAM156A/TMhz2 跨膜蛋白29抗体
hz-8225R FAM160B1 FAM160B1蛋白抗体
hz-8226R FAM161B FAM161B蛋白抗体
hz-8227R FAM164B FAM164B蛋白抗体
hz-8228R FAHD2A 延胡索酰乙酰乙酸水解酶抗体
hz-8229R FAM101A FAM101A蛋白抗体
hz-8230R FAM102B FAM102B蛋白抗体
hz-8231R FAM104B FAM104B蛋白抗体
hz-8232R FRMD1 FRMD1蛋白抗体
hz-8233R FRMD2/FRMPD1 FRMD2蛋白抗体
hz-8234R FRMD3 FRMD3蛋白抗体
hz-8235R FRMD4A FRMD4A蛋白抗体
hz-8236R FRMD4B FRMD4B蛋白抗体
hz-8237R FRMD5 FRMD5蛋白抗体
hz-8238R FRMD6 FRMD6蛋白抗体
hz-8239R FRMD7 FRMD7蛋白抗体
hz-8240R FRMD8 FRMD8蛋白抗体
hz-8241R CTDSPL CTDSPL蛋白抗体
hz-8242R CTDSPL2 CTDSPL2蛋白抗体
hz-8243R CUEDC1 CUE结构域蛋白1抗体
hz-8244R CA XI/Carbonic Anhydrase XI 碳酸酐酶11抗体
关注
已认证
