英文名称 RNF31
中文名称 环指蛋白31抗体
别 名 HOIL 1L interacting protein; HOIL-1-interacting protein; HOIL-1L interacting protein; HOIL1L interacting protein; HOIP; RING finger protein 31; RNF31; RNF31_HUMAN; ZIBRA; Zinc in between ring finger ubiquitin associated domain; Zinc in-between-ring-finger ubiquitin associated domain; Zinc in-between-RING-finger ubiquitin-associated domain protein; FLJ10111; FLJ23501
环指蛋白31抗体
说 明 书 0.2ml
研究领域 细胞生物 染色质和核信号 信号转导 转录调节因子 表观遗传学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 118kDa
细胞定位 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RNF31/HOIP
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
环指蛋白31抗体产品介绍 background:
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.
Function:
E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.
Subunit:
Interacts with MUSK. Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximative 600 kDa suggesting a heteromultimeric assembly of its subunits. Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner. Contains 1 UBA domain.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Expressed in both normal and transformed breast epithelial cell lines.
Similarity:
Contains 1 IBR-type zinc finger.
Contains 3 RanBP2-type zinc fingers.
Contains 2 RING-type zinc fingers.
Contains 1 UBA domain.
Gene ID:
55072
Database links:
Entrez Gene: 55072 Human
Entrez Gene: 268749 Mouse
Omim: 612487 Human
SwissProt: Q96EP0 Human
SwissProt: Q924T7 Mouse
Unigene: 375217 Human
Unigene: 434081 Human
Unigene: 23748 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白31抗体
hz-7969R ARMC3 (Cancer/testis antigen 81) 肿瘤/睾丸抗原81抗体
hz-7970R ARS2 砷酸盐耐药蛋白ARS2抗体
hz-7971R ARSA 芳香基硫酸酯酶1抗体
hz-7972R ASNA1 砷酸盐转运三磷酸腺苷酶抗体
hz-7973R ATE1 精氨酸tRNA的蛋白转移酶1抗体
hz-7974R ATX2 脊髓小脑共济失调2型蛋白抗体
hz-7975R ATXN7L1 共济失调蛋白7样1抗体
hz-7976R ATXN7L2 共济失调蛋白7样2抗体
hz-7977R BCNP B淋巴细胞新型蛋白1抗体
hz-7978R BEX4 脑表达X连锁蛋白4抗体
hz-7940R ABCA5 三磷酸腺苷结合盒转运蛋白A亚基5抗体
hz-7979R BTBD7 BTB/POZ结构域蛋白7抗体
hz-7980R GUSB/beta glucuronidase β葡萄糖醛酸苷酶抗体
hz-7981R CA13 碳酸酐酶
hz-7982R HOXC9 同源盒蛋白HOXC9抗体
hz-7983R CA6 碳酸酐酶6抗体
hz-7984R CA7 碳酸酐酶7抗体
hz-7985R CCBE1 胶原蛋白和钙结合表皮生长因子结构域1抗体
hz-7986R CCDC102B 卷曲螺旋结构域蛋白102B抗体
hz-7987R CCDC16/ZNF83 卷曲螺旋结构域蛋白16抗体
hz-7988R CCDC21 卷曲螺旋结构域蛋白21抗体
hz-7989R CCDC52 卷曲螺旋结构域蛋白52抗体
hz-7990R CCDC6 卷曲螺旋结构域蛋白6抗体(乳头状甲状腺癌编码蛋白)
hz-7991R CCDC7 卷曲螺旋结构域蛋白7抗体
hz-7992R CCDC80 卷曲螺旋结构域蛋白80抗体
hz-7993R CD163L1 CD163蛋白样1抗体
hz-7994R CDAN1 先天性红细胞生成异常性贫血蛋白1抗体
hz-7995R CDK2AP2 细胞周期素依赖激酶2相关蛋白2抗体
hz-7996R CEACAM21 癌胚抗原相关细胞粘附分子21抗体
hz-7997R CDKAL1 周期素依赖性激酶5调节蛋白1样蛋白1抗体
hz-7998R CEACAM16/CEAL2 癌胚抗原相关细胞粘附分子16抗体
hz-7999R CEACAM19/CEAL1 癌胚抗原相关细胞粘附分子19抗体
hz-8012R ADCK5 ADCK5蛋白抗体
hz-8013R ITGB1BP2/CHORDC3 整合素β1结合蛋白2抗体
hz-8014R CLDND2 膜蛋白CLDND2抗体
hz-8015R CLLD7 鸟嘌呤核苷酸交换因子CLLD7抗体