环指蛋白149抗体

英文名称    RNF149    

中文名称    环指蛋白149抗体    

别    名    DNA polymerase-transactivated protein 2; E3 ubiquitin-protein ligase RNF149; RING finger protein 149; RN149_HUMAN; Rnf149.    

环指蛋白149抗体      

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    40kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RNF149    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.    

环指蛋白149抗体产品介绍    background:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF149 (RING finger protein 149), also known as DNAPTP2 (DNA polymerase-transactivated protein 2) or E3 ubiquitin-protein ligase RNF149, is a 400 amino acid single-pass membrane protein that contains one PA (protease associated) domain and a single RING-type zinc finger. The gene encoding RNF149 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.

Function:
E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. 

Subcellular Location:
Membrane.

Similarity:
Contains 1 PA (protease associated) domain. 
Contains 1 RING-type zinc finger. 

Gene ID:
284996

Database links:

Entrez Gene: 284996 Human

Entrez Gene: 67702 Mouse

Entrez Gene: 363222 Rat

SwissProt: Q8NC42 Human

SwissProt: Q3U2C5 Mouse

Unigene: 142074 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

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