中间丝相关蛋白抗体

英文名称    Repetin    

中文名称    中间丝相关蛋白抗体    

别    名    Intermediate filament associated protein; RPTN; RPTN_HUMAN.    

中间丝相关蛋白抗体         

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  信号转导  细胞周期蛋白  细胞分化      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow, Horse,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    91kDa    

细胞定位    细胞外基质 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Repetin    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

中间丝相关蛋白抗体 产品介绍    background:
Repetin is a 784 amino acid secreted protein that belongs to the S100-fused protein family. Repetin is an extracellular epidermal matrix protein that is expressed in the epidermis and at high levels in eccrine sweat glands, the inner sheaths of hair roots and the filiform papilli of the tongue. A multifunctional epidermal matrix protein, repetin is involved in the cornified cell envelope formation. Containing two EF-hand domains, repetin’s recombinant N-terminal domain binds calcium reversibly. Repetin and trichohyalin may compensate for absent loricrin. The repetin gene contains three exons, two introns and spans at least 5.6 kb. The repetin gene is conserved in cow, mouse and rat, and maps to human chromosome 1q21.3.

Function:
Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.

Subcellular Location:
Secreted; extracellular space; extracellular matrix.

Tissue Specificity:
Repetin is a multifunctional epidermal matrix protein involved in the cornified cell envelope formation. It reversibly binds calcium. Expression is scattered in the normal epidermis but strong in the acrosyringium, the inner hair root sheat and in the filiform papilli of the tongue.

Post-translational modifications:
Potential substrate of transglutaminase. Some arginines are probably converted. 
Phosphorylated upon DNA damage, probably by ATM or ATR. 

Similarity:
Belongs to the S100-fused protein family. 
Contains 2 EF-hand domains.

Gene ID:
126638

Database links:

Entrez Gene: 126638 Human

Entrez Gene: 20129 Mouse

Omim: 613259 Human

SwissProt: Q6XPR3 Human

SwissProt: P97347 Mouse

Unigene: 376144 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

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