环指蛋白11抗体

英文名称    RNF11    

中文名称    环指蛋白11抗体    

别    名    CGI 123; RING finger protein 11; RNF11; RNF11_HUMAN; Sid 1669; SID1669.    

环指蛋白11抗体     

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    11kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RNF11    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

环指蛋白11抗体产品介绍    background:
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]

Function:
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. 

Subunit:
Interacts (when phosphorylated) with 14-3-3. Interacts with the E3 ubiquitin-ligases NEDD4, ITCH, SMURF2 and WWP1 (By similarity). Also interacts with the E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2N, but neither with CDC34, nor with UBE2L3. Interacts with ZNF350, EPS15 and STAMBP. After TNF stimulation, interacts with TAX1BP1, TNFAIP3 and RIPK1; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with GGA1.

Subcellular Location:
Cytoplasm. Nucleus. Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1.

Tissue Specificity:
Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta. Highest expression in the skeletal muscle. In the brain, expressed at different levels in several regions: high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and extremely low levels in the corpus callosum (at protein level). Restricted to neurons, enriched in somatodendritic compartments and excluded from white matter (at protein level). In substantia nigra, present in cell bodies and processes of dopaminergic and nondopaminergic cells (at protein level). In Parkinson disease, sequestered in Lewy bodies and neurites. Overexpressed in breast cancer cells, but not detected in the surrounding stroma and weakly, if at all, in normal breast epithelial cells (at protein level). Also expressed in several tumor cell lines.

Post-translational modifications:
Ubiquitinated in the presence of ITCH, or SMURF2, and UBE2D1, as well as WWP1.
Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome. 
May be acylated at Cys-4, possibly palmitoylated. Acylation at both Gly-2 and Cys-4 is required for proper localization to the endosomes. 

Similarity:
Contains 1 RING-type zinc finger.

Gene ID:
26994

Database links:

Entrez Gene: 26994 Human

Omim: 612598 Human

SwissProt: Q9Y3C5 Human

Unigene: 309641 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

环指蛋白11抗体

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hz-6864R NALP12  NALP12抗体

hz-6865R NALP6  富含亮氨酸重复结构域蛋白6抗体

hz-6866R NLRP7  富含亮氨酸重复结构域蛋白7抗体

hz-6867R NLRP9  富含亮氨酸重复结构域蛋白9抗体

hz-6868R ARMER  ARMER抗体

hz-6869R HBXIP  乙型肝炎病毒X蛋白相互作用蛋白

hz-6870R ILP2  抑制细胞凋亡样蛋白2抗体

hz-6871R Interferon alpha 6  干扰素α6抗体

hz-6872R Rffl/RING finger protein 189  环指蛋白189抗体

hz-6873R CERKL  视网膜色素变性蛋白26抗体

hz-6874R Catalase  过氧化氢酶抗体

hz-6875R Adenylate kinase 2/AK2  腺苷酸激酶1抗体

hz-6876R FMRP/FMR1  脆性X智力低下蛋白抗体

hz-6877R IFRD1  干扰素相关发育调节蛋白1抗体（神经生长因子诱导蛋白PC4）

hz-6878R PERP/p53 apoptosis effector related to PMP22  p53凋亡相关作用蛋白PMP22抗体

hz-6879R phospho-GATA-4(ser 262)  磷酸化GATA结合蛋白4抗体

hz-6880R GPR109A/Puma gamma  G蛋白偶联受体109A抗体

hz-6881R SCN3B  电压门控钠通道SCN3B蛋白抗体

hz-6882R TIS11D/ERF2  表皮生长因子反应蛋白2抗体

hz-6883R xCT/CCBR1  钙离子通道阻端耐药蛋白CCBR1抗体

hz-6884R TSSC3  肿瘤抑制转移候选基因3抗体

hz-6885R TTI1  转录因子相互作用蛋白1抗体

hz-6886R WDR61  WD重复膜蛋白61抗体

hz-6887R RBR2/Rb2 p130  视网膜母细胞瘤样蛋白2抗体

hz-6888R BRCC3/BRCC36  乳腺癌易感基因复合物亚基蛋白3抗体

hz-6889R Casein Kappa/CSN3/COPS3  K-酪蛋白抗体

hz-6890R CXXC5  二硫键氧化还原酶锌指蛋白5抗体

hz-6891R DMTF1  周期素D相互作用蛋白1抗体

hz-6892R GMCL1L  生殖细胞样蛋白1样蛋白抗体

hz-6893R KLLN   Killin-p53调节复制抑制蛋白抗体

hz-6894R HFREP1/FGL1  肝细胞源性纤维蛋白原相关蛋白1抗体

hz-6895R Fibrinogen gamma chain  人纤维蛋白原γ链抗体

hz-6896R Fibrinopeptide B  纤维蛋白肽B抗体（血纤肽B）

hz-6898R Mitochondrial ribosomal protein L11  线粒体核糖体蛋白L11抗体

hz-6899R STK40  丝氨酸/苏氨酸蛋白激酶40抗体

hz-6900R BOD1  双向染色体细胞分裂蛋白1抗体

hz-5174R phospho-ANAPC1(Ser377)  磷酸化细胞周期末期促进复合蛋白APC1抗体

hz-1176R Agrin  聚集蛋白抗体

hz-6901R CENPT  着丝粒蛋白T抗体

hz-6902R RanGAP1  RAN GTPase酶激活蛋白1抗体

hz-6904R PRC1  胞质分裂调控蛋白1抗体