环指蛋白6抗体

英文名称    RNF6    

中文名称    环指蛋白6抗体    

别    名    E3 ubiquitin-protein ligase RNF6; Ring finger protein (C3H2C3 type) 6; Ring finger protein 6; RING H2 protein; RING H2 protein RNF6; RNF 6; RNF6; RNF6_HUMAN; SPG2.    

环指蛋白6抗体        

说 明 书    0.2ml      

研究领域    细胞生物  免疫学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    78kDa    

细胞定位    细胞核 细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RNF6    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

环指蛋白6抗体产品介绍    background:
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008].

Function:
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.

Subunit:
Interacts with LIMK1 (By similarity). Interacts with AR.

Subcellular Location:
Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Note=Localizes to the PML nuclear bodies in Sertoli cells.

Tissue Specificity:
Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.

DISEASE:
Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the RNF12 family. 
Contains 1 RING-type zinc finger.

Gene ID:
6049

Database links:

Entrez Gene: 6049 Human

Entrez Gene: 74132 Mouse

Entrez Gene: 100174577 Orangutan

Entrez Gene: 304271 Rat

Omim: 604242 Human

SwissProt: Q9Y252 Human

SwissProt: Q9DBU5 Mouse

Unigene: 136885 Human

Unigene: 26696 Mouse

Unigene: 53030 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

环指蛋白6抗体

hz-6747R TERT/EST2/Telomerase reverse transcriptase  端粒酶相关蛋白2抗体（端粒酶逆转录酶）

hz-6748R UBAP1  泛素相关蛋白1抗体（鼻咽癌相关基因20蛋白）

hz-6749R UXT/Ubiquitously expressed transcript  广泛表达转录蛋白UXT抗体

hz-6750R WDR16  WD重复蛋白16抗体

hz-6751R WDR19  WD重复膜蛋白19抗体

hz-6752R WSB2/WD SOCS box protein 2  信号传导抑制蛋白WD重复蛋白2抗体

hz-6753R WWP1  WW结构域E3泛素连接酶1抗体

hz-6754R YY1AP1/HCCA2  肝癌相关蛋白2抗体（转录因子YY1结合蛋白1抗体）

hz-6755R ZNF146  锌指蛋白146抗体

hz-6756R ZNF23  锌指蛋白23抗体

hz-6757R ZNF364/BCA2/RNF115  乳腺癌相关基因2抗体（锌指蛋白364）

hz-6758R FAM89B/MMTV-R  乳腺肿瘤病毒受体同源蛋白抗体

hz-6759R IL-11RA  白介素11受体α/IL-11Rα抗体

hz-6760R KCNQ-1  钾离子通道蛋白家族KCNQ1抗体

hz-6761R IL-10  白细胞介素-10抗体

hz-6762R LIPG/Endothelial lipase  内皮脂肪酶抗体

hz-6763R MSR1/CD204  巨噬细胞清道夫受体1/2/3抗体

hz-6764R NPC1/Nihzann Pick C1  尼曼匹克C1前体蛋白抗体

hz-6765R Perilipin A+B  脂滴包被蛋白A+B抗体

hz-6766R FLIP delta + gamma  凋亡调节蛋白δ+γ抗体

hz-6767R PDC6I/Alix  调亡诱导因子6相互作用蛋白/多巴胺受体相互作用蛋白4抗体

hz-6768R PEF1  调亡诱导因子家族蛋白PEF1抗体

hz-6769R PHAPI2/APRIL  酸性核磷蛋白32家族B抗体

hz-6770R DRAK1/STK17A  丝氨酸/苏氨酸蛋白激酶17A抗体（DAP凋亡诱导蛋白激酶1）

hz-6771R ERN2  内质网核信号转导蛋白2抗体

hz-6772R A1BG  α1B糖蛋白抗体

hz-6773R A1CF/Apo B RNA editing protein  载脂蛋白B-mRNA编码蛋白抗体

hz-6774R FASTKD1  Fas活化激酶结构域蛋白1抗体

hz-6775R FASTKD2  Fas活化激酶结构域蛋白2抗体

hz-6776R FASTKD5  Fas活化激酶结构域蛋白5抗体

hz-6777R HIPK3  Fas相互作用蛋白激酶3抗体

hz-6778R MAP3K9  丝裂原活化蛋白激酶3K9抗体

hz-6779R phospho-MAP3K9+MAP3K10(Thr312 + Thr266)  磷酸化丝裂原活化蛋白激酶3K9抗体

hz-6780R TYRO3/MER+SKY  受体酪氨酸激酶抗体

hz-6781R MLK2/MAP3K10  丝裂原活化蛋白激酶3K10抗体

hz-6782R MST4  丝氨酸/苏氨酸蛋白激酶MST4抗体

hz-6783R MAP3K14/NFkB Inducing Kinase NIK  丝裂原活化蛋白激酶3K14抗体

hz-6784R Cullin 5/CUL5  血管加压素激活钙启动受体蛋白1抗体

hz-6786R AQP8/Aquaporin 8  水通道蛋白8抗体

hz-6787R SLC26A4  钠碘单独转运蛋白SLC26A4抗体

hz-6788R Granzyme K  颗粒酶K抗体

hz-6789R SRGN/Chondroitin sulfate proteoglycan core protein  硫酸软骨素多糖核心蛋白抗体

hz-6790R 14-3-3 zeta/delta  14-3-3 protein ζ/δ抗体

hz-6791R AIFM3  凋亡诱导因子3抗体

hz-6792R APIP/Apaf1 Interacting Protein  凋亡蛋白活性因子1相互作用蛋白抗体

hz-6793R APPD/LAPF  凋亡诱导蛋白D抗体