英文名称 RNF6
中文名称 环指蛋白6抗体
别 名 E3 ubiquitin-protein ligase RNF6; Ring finger protein (C3H2C3 type) 6; Ring finger protein 6; RING H2 protein; RING H2 protein RNF6; RNF 6; RNF6; RNF6_HUMAN; SPG2.
环指蛋白6抗体
说 明 书 0.2ml
研究领域 细胞生物 免疫学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
细胞定位 细胞核 细胞浆 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RNF6
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
环指蛋白6抗体产品介绍 background:
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008].
Function:
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
Subunit:
Interacts with LIMK1 (By similarity). Interacts with AR.
Subcellular Location:
Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Note=Localizes to the PML nuclear bodies in Sertoli cells.
Tissue Specificity:
Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
DISEASE:
Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the RNF12 family.
Contains 1 RING-type zinc finger.
Gene ID:
6049
Database links:
Entrez Gene: 6049 Human
Entrez Gene: 74132 Mouse
Entrez Gene: 100174577 Orangutan
Entrez Gene: 304271 Rat
Omim: 604242 Human
SwissProt: Q9Y252 Human
SwissProt: Q9DBU5 Mouse
Unigene: 136885 Human
Unigene: 26696 Mouse
Unigene: 53030 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白6抗体
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hz-6761R IL-10 白细胞介素-10抗体
hz-6762R LIPG/Endothelial lipase 内皮脂肪酶抗体
hz-6763R MSR1/CD204 巨噬细胞清道夫受体1/2/3抗体
hz-6764R NPC1/Nihzann Pick C1 尼曼匹克C1前体蛋白抗体
hz-6765R Perilipin A+B 脂滴包被蛋白A+B抗体
hz-6766R FLIP delta + gamma 凋亡调节蛋白δ+γ抗体
hz-6767R PDC6I/Alix 调亡诱导因子6相互作用蛋白/多巴胺受体相互作用蛋白4抗体
hz-6768R PEF1 调亡诱导因子家族蛋白PEF1抗体
hz-6769R PHAPI2/APRIL 酸性核磷蛋白32家族B抗体
hz-6770R DRAK1/STK17A 丝氨酸/苏氨酸蛋白激酶17A抗体(DAP凋亡诱导蛋白激酶1)
hz-6771R ERN2 内质网核信号转导蛋白2抗体
hz-6772R A1BG α1B糖蛋白抗体
hz-6773R A1CF/Apo B RNA editing protein 载脂蛋白B-mRNA编码蛋白抗体
hz-6774R FASTKD1 Fas活化激酶结构域蛋白1抗体
hz-6775R FASTKD2 Fas活化激酶结构域蛋白2抗体
hz-6776R FASTKD5 Fas活化激酶结构域蛋白5抗体
hz-6777R HIPK3 Fas相互作用蛋白激酶3抗体
hz-6778R MAP3K9 丝裂原活化蛋白激酶3K9抗体
hz-6779R phospho-MAP3K9+MAP3K10(Thr312 + Thr266) 磷酸化丝裂原活化蛋白激酶3K9抗体
hz-6780R TYRO3/MER+SKY 受体酪氨酸激酶抗体
hz-6781R MLK2/MAP3K10 丝裂原活化蛋白激酶3K10抗体
hz-6782R MST4 丝氨酸/苏氨酸蛋白激酶MST4抗体
hz-6783R MAP3K14/NFkB Inducing Kinase NIK 丝裂原活化蛋白激酶3K14抗体
hz-6784R Cullin 5/CUL5 血管加压素激活钙启动受体蛋白1抗体
hz-6786R AQP8/Aquaporin 8 水通道蛋白8抗体
hz-6787R SLC26A4 钠碘单独转运蛋白SLC26A4抗体
hz-6788R Granzyme K 颗粒酶K抗体
hz-6789R SRGN/Chondroitin sulfate proteoglycan core protein 硫酸软骨素多糖核心蛋白抗体
hz-6790R 14-3-3 zeta/delta 14-3-3 protein ζ/δ抗体
hz-6791R AIFM3 凋亡诱导因子3抗体
hz-6792R APIP/Apaf1 Interacting Protein 凋亡蛋白活性因子1相互作用蛋白抗体
hz-6793R APPD/LAPF 凋亡诱导蛋白D抗体