磷酸化Runx3抗体

英文名称    phospho-RUNX3(Ser338)    

中文名称    磷酸化Runx3抗体    

别    名    p-RUNX3(Ser338); RUNX 3; RUNX-3; Runt-related transcription factor 3; Core-binding factor, alpha 3 subunit; CBF-alpha 3; Acute myeloid leukemia 2 protein; OncogeneAML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEBP2-alpha C; PEA2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; Core-binding factor, alpha 3 subunit; CBF-alpha 3; Acute myeloid leukemia 2 protein; Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEBP2-alpha C; RUNX3_HUMAN; PEA2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit.    

 磷酸化Runx3抗体     

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  免疫学  转录调节因子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    44kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthesised phosphopeptide derived from human RUNX3 around the phosphorylation site of Ser338    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

 磷酸化Runx3抗体产品介绍    background:
RUNX3 binds to the core site of murine Leukemia virus, the core sequences in the enhancer of the polyomavirus, and also to the enhancers of the T-cell receptor genes. May be involved in the control of cellular proliferation and/or differentiation (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain.DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1, Subcellular location in Nucleus.

Function:
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.

Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK.

Subcellular Location:
Nucleus. Cytoplasm. The tyrosine phosphorylated form localizes to the cytoplasm.

Post-translational modifications:
Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN. 

Similarity:
Contains 1 Runt domain. 

Database links:
UniProtKB/Swiss-Prot: Q13761.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

 磷酸化Runx3抗体

hz-6376R DDIT4L  DNA损伤诱导转录样蛋白4抗体

hz-6377R DEAF1/Deformed Epidermal Autoregulatory Factor 1  畸形表皮自调节因子1抗体

hz-6378R EID3  E1A样分化抑制因子3抗体

hz-6380R ERCC6L  发育相关蛋白ERCC6L抗体（乙醇致畸因子）

hz-6381R FAM107A  肾细胞癌下调蛋白1抗体

hz-6382R FRK/PTK5  胃肠道相关酪氨酸激酶抗体（蛋白酪氨酸激酶5）

hz-6383R GANP  生发中心相关核蛋白MCM3抗体

hz-6384R GIDRP88  生长抑制和分化相关蛋白抗体

hz-6385R Gas1  生长休止特定蛋白1抗体

hz-6386R MDFIC  肌原调节抑制蛋白抗体

hz-6387R MEI-1  减数分裂缺陷蛋白1抗体

hz-6388R MTBP/MDM2BP  双微体2癌基因结合蛋白抗体

hz-6389R NIRF/RNF107  环指蛋白107抗体

hz-6390R Necdin  生长抑制蛋白NDN抗体

hz-6391R RPRD1A/P15RS  细胞周期依赖性激酶抑制相关蛋白抗体

hz-6392R PCNP  PEST含核蛋白抗体

hz-6393R PLK4/STK18  丝氨酸/苏氨酸蛋白激酶18

hz-6394R Quiescin Q6/QSOX1  巯基氧化酶1抗体

hz-6395R LEU5/RFP2  白血病相关蛋白5抗体

hz-6396R SAPK3/MAPK12  应激活化蛋白激酶3抗体（丝裂原活化蛋白激酶12）

hz-6397R SCGB3A1  结合珠蛋白家族3A1抗体

hz-6398R SEI2/SERTAD2  调控周期蛋白依赖蛋白激酶SEI2抗体

hz-6399R SIPA1  信号诱导增殖相关蛋白1抗体

hz-0177R AGER  晚期糖基化终末产物特异性受体抗体

hz-5159R Fast skeletal Myosin/MRLC2  骨骼肌肌球蛋白轻链2抗体

hz-6400R TFDP3  转录因子DP3抗体（肝癌相关抗原661）

hz-6401R BMP1  骨形态发生蛋白1/胶原C蛋白肽链内切酶抗体

hz-6402R SMARCA2/BRM  ATP依赖解旋酶SMARCA2抗体

hz-6403R Ferritin Light Chain  铁蛋白轻链抗体

hz-6404R CECR5  猫眼综合征染色体候选基因5抗体

hz-6405R CEE  跨膜结构域边缘蛋白CEE抗体

hz-6406R CESK1  分子伴侣CESK1蛋白抗体

hz-6407R CHCHD2  丙型肝炎NS2反式调节蛋白/衰老相关的基因10蛋白抗体

hz-6408R CHKL/Ethanolamine kinase beta  乙醇胺激酶β抗体

hz-6409R CHORDC1  含半胱氨酸和组氨酸丰富域蛋白1抗体

hz-6410R HIV2 gp36  人类免疫缺陷病毒2型抗体（艾滋病病毒）