磷酸化蛋白酶体PSMβ7抗体

英文名称    phospho-Proteasome 20S beta 7(Ser214)    

中文名称    磷酸化蛋白酶体PSMβ7抗体    

别    名    Proteasome 20S beta 7 (phospho S214); Proteasome 20S beta 7 (phospho Ser214); p-Proteasome 20S beta 7 (S214); p-Proteasome 20S beta 7 (Ser214); 20S Proteasome β7; Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome (prosome macropain) subunit beta type 7; Proteasome beta 7 subunit; Proteasome catalytic subunit 2; Proteasome subunit alpha; Proteasome subunit beta 7; Proteasome subunit beta type-7; Proteasome subunit Z; PSB7_HUMAN; PSMB7; PUP1.    

磷酸化蛋白酶体PSMβ7抗体       

说 明 书    0.2ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  细胞周期蛋白  细胞分化      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    25kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human Proteasome 20S beta 7 around the phosphorylation site of Ser214    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化蛋白酶体PSMβ7抗体产品介绍    background:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.The proteasome represents a large protein complex that exists inside all eukaryotes and archaea, and in some bacteria. The main function of proteasomes is to degrade unnecessary or damaged proteins by proteolysis. The most common form of the proteasome, known as the 26S Proteasome, contains one 20S Proteasome core particle structure and two 19S regulatory caps. The 20S Proteasome core is hollow and forms an enclosed cavity, where proteins are degraded, as well as openings at the two ends to allow the target protein to enter. The 20S Proteasome core particle contains many subunits, depending on the organism. 

Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.

Subunit:
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic equivalent immune-specific subunit PSMB10. Interacts with HIV-1 TAT protein.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues.

Similarity:
Belongs to the peptidase T1B family.

Gene ID:
5695

Database links:

Entrez Gene: 5695 Human

Entrez Gene: 19177 Mouse

Entrez Gene: 100037992 Pig

Entrez Gene: 85492 Rat

Omim: 604030 Human

SwissProt: Q2TBP0 Cow

SwissProt: Q99436 Human

SwissProt: P70195 Mouse

SwissProt: A1XQU1 Pig

SwissProt: Q9JHW0 Rat

Unigene: 213470 Human

Unigene: 389251 Mouse

Unigene: 3846 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷酸化蛋白酶体PSMβ7抗体

hz-6317R phospho-PLB/phospholamban(phospho Ser16+Thr17)  磷酸化心脏磷蛋白抗体

hz-6318R ASM/Acid sphingomyelinase  酸性神经鞘磷脂酶抗体

hz-6319R IL-1 Beta/IL-1B  白介素1β抗体

hz-6320R BFAR/RNF47  环指蛋白47抗体

hz-6321R WISP1  Wnt1信号通路蛋白1抗体

hz-6322R Annexin A8  膜粘连蛋白8抗体

hz-6323R CD105/Endoglin  CD105抗体

hz-6325R GLUT10/Glucose Transporter GLUT10  葡萄糖转运蛋白10抗体

hz-6326R CD54/ICAM-1  细胞间粘附分子1抗体

hz-6327R Filaggrin  兜甲蛋白抗体

hz-6329R Sortilin/NTR3/Gp95  神经降压素受体3抗体（糖蛋白95）

hz-6330R IFNA16/Interferon alpha 16  干扰素α16抗体

hz-6331R NET1  去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体

hz-6332R ABCA2  三磷酸腺苷结合盒转运蛋白2抗体

hz-6333R ApoB/Apolipoprotein B  载脂蛋白B抗体

hz-6334R ORP8  氧化固醇结合蛋白8抗体

hz-6335R ALOX15B/15 Lipoxygenase 2  花生四烯酸15脂氧合酶2抗体

hz-6336R APOB48R  载脂蛋白B受体抗体

hz-6337R ARH/LDL receptor adaptor protein  低密度脂蛋白受体衔接蛋白抗体

hz-6338R APOC4/Apolipoprotein CIV  载脂蛋白C4抗体

hz-6339R HDLBP/vigilin  高密度脂蛋白结合蛋白抗体

hz-6346R KAT13D/CLOCK  生物钟KAT13D蛋白抗体

hz-6347R Rex1/Zinc finger protein 754  锌指蛋白754抗体

hz-6348R PIWIL3  piwi样3蛋白抗体

hz-6349R VGF/Nerve growth factor inducible  神经生长因子诱导蛋白抗体

hz-6350R pan methyl Lysine  泛甲基赖氨酸抗体

hz-6351R DAP1  死亡相关蛋白1抗体

hz-6352R Adenylosuccinate Lyase  腺苷酸琥珀酸裂解酶抗体

hz-6353R HIPK2  Fas相互作用蛋白激酶2抗体

hz-6359R Glutamine PRPP amidotransferase  谷氨酰胺磷酸核糖基焦磷酸酰胺基转移酶

hz-6365R CROT/COT  过氧化物酶体肉碱酰基转移酶抗体

hz-6369R PAICS  磷酸核糖胺咪唑羧化酶抗体

hz-6370R p70 S6 kinase alpha  磷酸化核糖体p70 S6蛋白激酶抗体

hz-6371R Protamine 2  鱼精蛋白2抗体

hz-6372R Hepcidin-25  铁调节蛋白25抗体

hz-6373R CGR19  细胞生长调控蛋白19抗体（环指蛋白197）

hz-6374R FPR3/Lipoxin A4 receptor  甲酰肽受体3抗体（脂氧素A4受体）

hz-6375R CHMP1A  染色体修饰蛋白1抗体（金属蛋白酶1）