英文名称 RNF187
中文名称 环指蛋白187抗体
别 名 E3 ubiquitin-protein ligase RNF187; Protein RNF187; RACO-1; RING domain AP1 coactivator 1; RING finger protein 187; RN187_HUMAN; RNF187.
环指蛋白187抗体
说 明 书 0.2ml
研究领域 细胞生物 免疫学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Rabbit,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
细胞定位 细胞核 细胞浆
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RNF187
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
环指蛋白187抗体 产品介绍 background:
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Function:
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Subunit:
Interacts with JUN, independently of JUN phosphorylation.
Subcellular Location:
Cytoplasm. Nucleus. Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.
Post-translational modifications:
Ubiquitinated; undergoes 'Lys-48'-linked autoubiquitination in the absence of growth factors and MAP3K1-induced 'Lys-63'-linked polyubiquitination. 'Lys-48'-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced 'Lys-63'-linked polyubiquitination results in the stabilization of the protein. 'Lys-48'- and 'Lys-63'-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195, Lys-223 and Lys-224) and are thus mutually exclusive. Other sites of ubiquitination are not excluded.
Similarity:
Contains 1 RING-type zinc finger.
Gene ID:
149603
Database links:
Entrez Gene: 149603 Human
Entrez Gene: 108660 Mouse
Entrez Gene: 360533 Rat
SwissProt: Q5TA31 Human
SwissProt: Q8BFX1 Mouse
SwissProt: D3Z8N2 Rat
Unigene: 356377 Human
Unigene: 679030 Human
Unigene: 249986 Mouse
Unigene: 100245 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白187抗体
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