英文名称 RNF169
中文名称 环指蛋白169抗体
别 名 KIAA1991; RING finger protein 169; RN169_HUMAN.
环指蛋白169抗体
说 明 书 0.1ml 0.2ml
研究领域 细胞生物 免疫学
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 77kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RNF169
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
环指蛋白169抗体 产品介绍 background:
RNF169 contains 1 RING type zinc finger. The exact functions of RNF169 remain unknown.
Function:
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
Subcellular Location:
Nucleus, nucleoplasm. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products.
Similarity:
Belongs to the RNF169 family.
Contains 1 RING-type zinc finger.
Gene ID:
254225
Database links:
Entrez Gene: 254225 Human
Entrez Gene: 108937 Mouse
SwissProt: Q8NCN4 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白169抗体
hz-4801R Salmonella typhimurium 鼠伤寒沙门氏菌
hz-4802R Salmonella paratyphi a 甲型副伤寒沙门氏菌抗体
hz-4803R Salmonella enteritidis/SE 肠炎沙门氏菌抗体
hz-4804R pig cholerae salmonella 猪霍乱沙门氏菌抗体
hz-4805R Duck salmonella 鸭沙门氏菌抗体
hz-4806R USP3 去泛素化酶3抗体
hz-4807R ATXN3L 小脑脊髓共济失调蛋白3抗体
hz-4808R Endomucin 内皮粘蛋白hzCN抗体
hz-4812R KLK3/Prostate Specific Antigen 激肽释放酶3/舒血管素3抗体
hz-4813R H5N1-H5 禽流感H5亚型全病毒抗体
hz-4814R Newcastle disease virus 鸡新城疫疫苗(鸡瘟4型混合病毒)抗体
hz-4815R CD3 epsilon CD3抗体
hz-4816R CD3 epsilon CD3抗体
hz-4817R CD4 CD4抗体
hz-4818R CD45/B220 白细胞共同抗原抗体
hz-4819R CD45/B220 白细胞共同抗原抗体
hz-4820R CD45/B220 白细胞共同抗原抗体
hz-4821R AFP 甲胎蛋白AFP抗体
hz-4826R CD83 CD83抗体
hz-4834R CD73/NT5 CD73抗体
hz-4835R MAL/MPV17 T淋巴细胞成熟相关蛋白抗体
hz-4836R CXC-R2 CXCR2/CD182
hz-4838R HE4 附睾分泌蛋白4抗体
hz-4839R nonstructural protein 1/NS1 A型流感病毒-NS1抗体(神经氨酸酶1)
hz-4846R Factor VII 凝血因子7抗体
hz-4847R phospho-ITGB4(Tyr1530) 磷酸化整合素β4抗体
hz-4848R phospho-RUNX3(Ser338) 磷酸化Runx3抗体
hz-4849R GLUT2 葡萄糖转运蛋白2
hz-4850R Collagen II/Chondrocalcin Ⅱ型胶原α1蛋白/软骨钙素抗体
hz-4851R Collagen II/Chondrocalcin Ⅱ型胶原α1蛋白/软骨钙素抗体
hz-4852R PIM3 丝氨酸/苏氨酸蛋白激酶PIM3抗体
hz-4856R Hepatitis C Virus NS5a 丙型肝炎病毒NS5A抗体
hz-4857R Hepatitis C Virus NS4B 丙型肝炎病毒NS4B抗体