G蛋白结合蛋白RAB11a抗体

英文名称    Rab11A    

中文名称    G蛋白结合蛋白RAB11a抗体    

别    名    Rab 11; Rab11A; Rab-11A; RAB 11A member oncogene family; Rab-11; RAB11 A; RAB11; RAB11A; RAB11A member RAS oncogene family; Ras related protein Rab 11A; Ras related protein Rab11A; Ras-related protein Rab-11A; RB11A_HUMAN; YL 8; YL8; MGC1490.    

G蛋白结合蛋白RAB11a抗体  

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  信号转导  G蛋白偶联受体  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Pig, Cow, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    24kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Rab11A    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

G蛋白结合蛋白RAB11a抗体产品介绍    background:
Rab11a, Rab11b and Rab25 are members of the Rab11 family of small Ras-like GTPases. Rab11 (isoforms Rab11a and Rab11b) functions as a key regulator in the recycling of perinuclear, plasma membrane and Golgi compartment endosomes (1,2). Despite some overlap, distinct differences exist between Rab11a and Rab11b in both their cellular distribution and functional roles. Rab11a is ubiquitously expressed while Rab11b is found mainly in the heart and brain (3,4). Like other Rab proteins, Rab11 exerts its function via interactions with Rab11 family interacting proteins (FIPs). While there are three distinct classes of FIPs, all appear to share a conserved carboxy-terminal Rab-binding domain that allows Rab-FIP protein interaction. When bound together, these proteins are thought to regulate membrane-associated protein sorting (5,6).

Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. 

Subunit:
Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. May interact with TBC1D14.

Subcellular Location:
Cell membrane. Recycling endosome membrane. Cleavage furrow. Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

Database links:
UniProtKB/Swiss-Prot: P62491.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

G蛋白结合蛋白RAB11a抗体

EP-1041 Ricinus communis agglutinin,RCA ELISA Kit  蓖麻凝集素

hz-1041 Mouse D-Lactate Dhzydrogenase,D-LDH ELISA Kit   小鼠D-乳酸脱氢酶

EA-1041 F1+2 (Rabbit prothrombin fragment 1+2) ELISA Kit  兔凝血酶原片段F1+2

EA-1042 ADM (Rabbit soluble endothelial protein C receptor) ELISA Kit  兔子肾上腺髓质素

hz-1042 D-LDH ELISA Kit   大鼠D-乳酸脱氢酶

hz-1042 VEGFR-2/sFLK-1(Human soluble vascular endothelial growth factor receptor-2) ELISA Kit  人可溶性血管内皮生长因子受体2

EP-1042 Pisum sativum agglutinin,PSA ELISA Kit  豌豆凝集素

hz-1042 Rat Progesterone receptor,PROGR ELISA kit  小鼠孕酮受体

EP-1043 Dolichos bifows agglutinin,DBA ELISA Kit  双花扁豆凝集素

hz-1043 TSLP(Human thymic stromal lymphopoietin) ELISA Kit  人胸腺基质淋巴细胞生成素

hz-1043 TARC/CCL17 ELISA Kit  大鼠胸腺活化调节趋化因子

EA-1043 sEPCR (Rabbit soluble endothelial protein C receptor) ELISA Kit  兔子可溶性血管内皮细胞蛋白C受体

hz-1043 Mouse Insulin-like growth factor binding protein 6,IGFBP-6 ELISA kit   小鼠胰岛素样生长因子结合蛋白6

hz-1044 CH ELISA Kit  大鼠胆固醇

EA-1044 Lp- Alpha (Rabbit lipoprotein Alpha) ELISA Kit  兔脂蛋白α

hz-1044 PF/PFP(Human Perforin/Pore-forming protein) ELISA Kit  人穿孔素/成孔蛋白

EP-1044 Plant calmodulin,CAM ELISA Kit   植物钙调素

hz-1044 Mouse pulmonary activation regulated chhzokine,PARC ELISA Kit  小鼠肺部活化调节趋化因子

hz-1045 PTN(Human pleiotrophin) ELISA Kit  人多效生长因子

EA-1045 Apo-E (Rabbit Apolipoprotein E) ELISA Kit  兔载脂蛋白E

hz-1045 TG mouse ELISA Kit  小鼠甘油三酯

EP-1045 Plant hormone abscisic acid,ABA ELISA Kit  植物激素脱落酸

hz-1045 Mouse Lysozyme,LZM ELISA Kit   小鼠溶菌酶

hz-3357 valosin-containing protein kit/VCP (human)  人含缬酪肽蛋白

hz-1046 sCD28(human soluble cluster of differentiation 28) ELISA Kit  人可溶性CD28

hz-1046 Mouse Beta-catenin, Beta-cat ELISA Kit  小鼠β连环蛋白/联蛋白

hz-1046 LDL ELISA Kit   大鼠低密度脂蛋白

EP-1046 Plant Vitamin K1,VK1 ELISA Kit   植物维生素K1

EA-1046 apo-B100 (Rabbit apoprotein B100) ELISA Kit  兔载脂蛋白B100

EP-1047 Plant Vitamin B12,VB12 ELISA Kit   植物维生素B12