RAB3-GTP酶激活蛋白催化亚单位1抗体

英文名称    RAB3GAP1    

中文名称    RAB3-GTP酶激活蛋白催化亚单位1抗体    

别    名    DKFZp434A012; KIAA0066; P130; Rab3 GAP; Rab3 GAP p130; RAB3 GTPase activating protein 130 kDa subunit; Rab3 GTPase activating protein catalytic subunit; RAB3GAP; RAB3GAP130; WARBM1; RB3GP_HUMAN.    

RAB3-GTP酶激活蛋白催化亚单位1抗体  

说 明 书    0.2ml      

研究领域    细胞生物  发育生物学  神经生物学  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    110kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RAB3GAP1    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

RAB3-GTP酶激活蛋白催化亚单位1抗体产品介绍    background:
Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab 3 GAP p130, also known as Rab3 GTPase-activating protein catalytic subunit, is a 981 amino acid protein that belongs to the Rab3-GAP catalytic subunit family. Rab 3 GAP p130 converts active RAB3-GTP to the inactive form RAB3-GDP, and is required for normal eye and brain development. Defects in Rab 3 GAP p130 are the cause of Warburg micro syndrome 1 (WARBM1). WARBM1 is a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system and by microgenitalia. The Rab 3 GAP p130 protein may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. Existing as two alternatively spliced isoforms, the Rab 3 GAP p130 gene is conserved in chimpanzee, dog, cow, mouse, chicken, zebrafish and fruit fly, and maps to human chromosome 2q21.3.

Function:
RAB3GAP1 is a member of the RAB3 protein family which are implicated in regulated exocytosis of neurotransmitters and hormones. RAB3GAP, which is involved in regulation of RAB3 activity, is a heterodimeric complex consisting a 130-kD catalytic subunit and a 150-kD noncatalytic subunit. RAB3GAP specifically converts active RAB3-GTP to the inactive form RAB3-GDP (Aligianis et al., 2005 [PubMed 15696165].

Subunit:
The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2

Subcellular Location:
Cytoplasm. Note=In neurons, it is enriched in the synaptic soluble fraction.

Tissue Specificity:
Ubiquitous.

DISEASE:
Defects in RAB3GAP1 are the cause of Warburg micro syndrome type 1 (WARBM1) [MIM:600118]. A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. 

Similarity:
Belongs to the Rab3-GAP catalytic subunit family. 

Gene ID:
22930

Database links:

Entrez Gene: 22930 Human

Omim: 602536 Human

SwissProt: Q15042 Human

Unigene: 306327 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

RAB3-GTP酶激活蛋白催化亚单位1抗体

hz-0607P OAT-1 (Organic anion transporter 1)mouse、rat  阴离子转运蛋白-1（大、小鼠同源：人源见bs-0606P）

hz-0609P OAT-3(Organic anion transporter 3)  阴离子转运蛋白-3(抗原)

hz-0604P galectin 9   半乳糖凝集素9（抗原）

hz-0830P Oct-4  胚胎干细胞关键蛋白(多肽)

hz-0026P OPN(osteopontin)  骨桥蛋白（抗原）

hz-0740P P16/CDKN2A (Cyclin-dependent kinase inhibitor-2A)  抑癌基因p16（抗原）

hz-0741P p21/WAF1/CIP1   p21 核分裂抑制因子之一（抗原）

hz-0742P p27 (cyclin-dependent kinase inhibitor 1B)  p27(抗原)

hz-0723P P63 protein  P63 肿瘤抑制基因（抗原）

hz-0431P OPG(Osteoprotegerin)  护骨素(多肽抗原)

hz-0747P OPGL (Osteoprotegerin ligand)  骨保护蛋白配体(抗原)

hz-0427P P311 protein  增生性瘢痕相关蛋白（抗原）

hz-0769P PARP(poly ADP-ribose polymerase)  多腺苷二磷酸多聚酶抗原

hz-0270P Visfatin-1 (PBEF1)(NT) Human  内脂素/内脏脂肪素（人：N端多肽）、内脏脂肪素、 又称：前B细胞克隆增强因子、内肥素、腹脂素

hz-0272P Visfatin-1 (PBEF1)(NT)   内脂素/内脏脂肪素

hz-0273P PBEF (CT)  内脂素/B细胞克隆增强因子

hz-0731P PEDF (pigment epithelium-derived factor)  色素上皮源性因子(多肽抗原）

hz-0739P PAP2c (Phosphatidic acid phosphatase 2c)  磷脂酸磷酸酶2C（抗原）

hz-0689P PEPT1 (Peptide-transporters 1)  肠道肽转运蛋白(小肽转运蛋白)多肽

hz-0748P PTEN/MMAC1  一种肿瘤抑制基因抗原

hz-0420P PIBF(progesterone induced blocking factor)  孕激素诱导阻断因子(抗原)

hz-0665P PIWIL1(piwi-like 1)  piwi 样1蛋白(抗原)

hz-0530P PPAR Gamma (peroxisome proliferator-activated receptor-gamma)  过氧化酶活化增生受体γ（抗原）

hz-0490P PP2Ac  蛋白磷酸酶4(抗原)

hz-0378P Runx3  一种新发现的抑癌基因(抗原)

hz-0278P RRAD (Ras-related associated with diabetes )  RRAD(多肽抗原)

hz-0783P SDF-1/CXCL12 (stromal cell derived factor-1)  基质细胞衍生因子-1(抗原)

hz-0211P shank1(SH3 and multiple anleyrin repead domins protein 1)  shank1多肽抗原

hz-0444P slc22A17 (solute carrier famili 22)  溶质转运蛋白家族22成员17(多肽抗原)

hz-0496P SLC24A5 (solute carrier family 24, mhzber 5)  可溶性载质转运蛋白SLC24A5（抗原）

hz-0473P solute carrier family 1  溶质携带物家族-1(抗原)

hz-0478P SLC6A4 (solute carrier family 6)  钾依赖钠钙交换蛋白6(抗原)

hz-0615P Survivin  细胞凋亡抑制因子的一种（抗原）

hz-0726P BIRC5/Survivin variant  细胞凋亡抑制因子4（抗原）