受体辅助蛋白1抗体

英文名称    REEP1    

中文名称    受体辅助蛋白1抗体    

别    名    C2orf23; Chromosome 2 open reading frame 23; FLJ13110; Receptor accessory protein 1; Receptor expression-enhancing protein 1; Reep1; REEP1_HUMAN; SPG31.    

受体辅助蛋白1抗体      

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  神经生物学  细胞膜受体  G蛋白偶联受体      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    22kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human REEP1 (53-150aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

受体辅助蛋白1抗体产品介绍    background:
Transport of G protein-coupled receptors (GPCRs) to the cell surface membrane is critical for receptor-ligand recognition. Mammalian GPCR odorant receptors (ORs), when heterologously expressed in cells, are poorly expressed on the cell surface. REEP1 (receptor expression-enhancing protein 1), is a 201 amino acid multi-pass mitochondrion membrane protein that belongs to the DP1 family. REEP1 interacts with odorant receptor proteins and may enhance the cell surface expression of odorant receptors. Mutations in the REEP1 gene are the third most common cause of hereditary spastic paraplegia (HSP) after spastin and atlastin gene mutations. Mutations in the REEP1 gene also cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. The REEP1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana and rice, and maps to human chromosome 2p11.2.

Function:
May enhance the cell surface expression of odorant receptors.

Subunit:
Interacts with SPAST and ATL1; it preferentiallyinteracts with SPAST isoform 1. Interacts (via C-terminus) withmicrotubules. Interacts with odorant receptor proteins 

Subcellular Location:
Membrane. Mitochondrion membrane; Multi-passmembrane protein. Endoplasmic reticulum.

Post-translational modifications:
Belongs to the DP1 family.

DISEASE:
Defects in REEP1 are the cause of spastic paraplegia autosomal dominant type 31 (SPG31) [MIM:610250]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.

Similarity:
Belongs to the DP1 family.

Database links:
UniProtKB/Swiss-Prot: Q9H902.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

受体辅助蛋白1抗体

hz-2101P Thz 1/CD248(Tumor endothelial marker 1 precursor)  内涎蛋白/内皮唾液酸蛋白抗原

hz-0535P TFF3 (trefoil factor3)  三叶肽因子3(多肽)

hz-1144P TFPI-2 (tissue factor pathway inhibitor-2)  组织因子途径抑制剂-2抗原

hz-1838P TIEG1/KLF10(TGF-beta inducible early response gene 1)  TGF-β诱导早期应答基因1抗原

hz-0638P TGF- BetaR1/ALK (TGF-beta receptor type I)  转移生长因子–β受体1抗原

hz-1276P Erdj5/DNAJC10  Erdj5/DNAJC10多肽

hz-1334P Tie1/JTK14 peptide  上皮生长因子样域酪氨酸激酶1抗原

hz-1300P Tie2(Porcine tyrosine kinase with immunoglobulin-like and EGF-like domains 2)  上皮生长因子样域酪氨酸激酶2抗原

hz-1501P Rarres2/TIG2/Chhzerin(Retinoic acid receptor responder protein 2)  视黄酸受体应答蛋白2抗原

hz-1444P TLR3 (Toll-like receptor 3)  Toll样受体3抗原

hz-1021P TLR4/CD284 (Toll-like receptor 4)  Toll样受体4抗原

hz-1197P TLR5/CD285 (Toll-like receptor 5)  Toll样受体5抗原

hz-0525P TM(Thrombomodulin)  血栓调节蛋白多肽

hz-1327P Tn-C(Tenascin-C)C-Terminus  腱糖蛋白-C(固生蛋白)C端抗原

hz-2081P TNF-alpha  肿瘤坏死因子-α抗原

hz-0093P TNF- Beta(Tumor Necrosis Factor- Beta)  肿瘤坏死因子-β抗原

hz-2104P TNFAIP1(Tumor necrosis factor-alpha-induced protein 1)  肿瘤坏死因子α诱导蛋白1抗原

hz-0905P Acetylated-P53(Lys382) peptide  抗肿瘤P53抗原

hz-1211P TP I (topoisomerase I )  拓普西异构酶Ⅰ抗原

hz-1203P TOPO II Alpha/DNA TP II Alpha (DNA topoisomerase II Alpha)  DNA拓普西异构酶Ⅱ抗原

hz-1215P TPH (Trptophan Hydroxylase)  色氨酸羟化酶(多肽)

hz-0329P TRA16 (Testicular orphan nuclear receptor-4 (TR4)-associated protein)  睾丸激素受体相关蛋白/孤儿素受体相关蛋白(抗原)

hz-1202P TRADD(TNF receptor 1 associated via death domain)  有死亡区的肿瘤坏死因子受体1相关蛋白抗原

hz-1212P TRAF1  肿瘤坏死因子受体相关因子1抗原

hz-1213P TRAF2/TNF-R2 (TNF receptor-associated factor 2)  肿瘤坏死因子受体相关因子2抗原

hz-1185P TRAF3/CD40bp (CD40 binding protein)  肿瘤坏死因子受体相关蛋白3抗原

hz-1184P TRAF6 (TNF receptor-associated factor 6)  肿瘤坏死因子受体相关因子6抗原

hz-1214P TRAIL/Apo2L (tumor necrosis factor-related apoptosis-inducing ligand)  肿瘤坏死因子相关凋亡诱导配体/凋亡素2配体抗原

hz-1151P TRBF1 (Telomeric repeat binding factor 1)  端粒体复制结合因子1抗原

hz-0964P TRIM32(tripartite motif protein 32)  TRIM32抗原

hz-1243P Trop-2/Tpm2 peptide  原肌球蛋白抗原

hz-1220P TSARG4(Testis and spermatogenesis related gene 4)  生精细胞凋亡相关基因4抗原

hz-0546P TSGF(Tumor Specific Growth Fanctor)  恶性肿瘤特异性生长因子抗原

hz-0716P CIDEB peptide  CIDEB抗原

hz-1365P Tsg101(Tumor susceptibility gene 101 protein)  Tsg101抗原