Rap鸟嘌呤核苷酸交换因子2抗体

英文名称    RAPGEF2    

中文名称    Rap鸟嘌呤核苷酸交换因子2抗体    

别    名    KIAA0313; Neural RAP guanine nucleotide exchange protein; nRap GEP; NRAPGEP; PDZ domain containing guanine nucleotide exchange factor 1; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ GEF1; PDZ-GEF1; PDZGEF1; RA GEF; RA-GEF; Rap guanine nucleotide exchange factor 2; Rapgef2; RPGF2_HUMAN.    

Rap鸟嘌呤核苷酸交换因子2抗体      

说 明 书    0.2ml      

研究领域    细胞生物  神经生物学  信号转导  G蛋白偶联受体  交换蛋白  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    167kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RAPGEF2 (501-600aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

Rap鸟嘌呤核苷酸交换因子2抗体产品介绍    background:
SummaryMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Function:
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP.

Subunit:
Interacts with MAGI2.

Subcellular Location:
Cell membrane (By similarity). Note=Associated with the synaptic plasma membrane

Tissue Specificity:
Highest expression levels in brain. Lower expression levels in heart, kidney, lung, and placenta.

Post-translational modifications:
Phosphorylation by PLK2 promotes its activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 cyclic nucleotide-binding domain. 
Contains 1 N-terminal Ras-GEF domain. 
Contains 1 PDZ (DHR) domain. 
Contains 1 Ras-associating domain. 
Contains 1 Ras-GEF domain. 

Database links:

Entrez Gene: 9693 Human

Omim: 609530 Human

SwissProt: Q9Y4G8 Human

Unigene: 723853 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

Rap鸟嘌呤核苷酸交换因子2抗体

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hz-1363P Iba-1(Ionized calcium bindingadaptor molecule-1)  离子钙接头蛋白抗原

hz-0898P IFABP(Intestinal Fatty acid binding protein)  小肠型脂肪酸结合蛋白抗原

hz-1031P IFITM1 (interferon induced transmhzbrane protein 1)  干扰素诱导跨膜蛋白1抗原

hz-1578P human IFN- Alpha (Interferon Alpha )  干扰素-α抗原（人）

hz-1463P IFNGR1/CD119 peptide  干扰素-gamma受体1抗原

hz-1108P IGFBP-2 (Insulin-like Growth Factor Binding Protein 2)  胰岛素样生长因子结合蛋白-2（多肽）

hz-1434P IGFBP-3 (Insulin-like Growth Factor Binding Protein 3)C-term  胰岛素样生长因子结合蛋白-3抗原

hz-1312P IGF-IIBP3(Insulin like growth factor 2 mRNA binding protein 3)  胰岛素样生长因子2 mRNA 结合蛋白3抗原

hz-1156P IKB Beta (Inhibitor of KB)  KB抑制蛋白β(多肽)

hz-1287P IKB Alpha (Inhibitor of KB Alpha)  KB抑制蛋白α抗原

hz-0767P IL-12(Interleukin-12)  白介素12抗原（白细胞介素-12）

hz-1789P IL-12(Interleukin-12)human peptide  白介素12抗原(人)

hz-2604P IL-12R Beta2/IL12RB2 peptide  白细胞介素-12受体β2抗原

hz-0560P IL-13(Interleukin-13)  白介素13抗原

hz-1771P IL-14/Taxilin alpha  白介素14抗原

hz-1829P IL-15(Interleukin-15)  白细胞介素-15抗原

hz-1830P IL-16(Interleukin-16)  白介素16抗原

hz-0768P IL-16/LCF(interleukin-16)(Lymphocyte Chhzotactic Factor)  白细胞介素-16抗原

hz-1183P IL-17(Interleukin-17)  白介素-17抗原

hz-2140P IL-17(Interleukin-17)human  白介素-17抗原（人）

hz-0529P IL-18/IGIF(Interleukin-18)  白细胞介素-18/干扰素γ诱导因子

hz-1460P IL-23R(Interleukin-23 receptor)  白介素-23受体抗原

hz-0555P IL-1 Alpha (Interleukin-1 Alpha )  白介素1α抗原

hz-1191P IL-2 (Interleukin-2)Mouse、Ret  白介素2抗原（大、小鼠）

hz-0605P IL-2 (Interleukin-2)Human  IL-2抗原（人）

hz-1193P IL-23(Interleukin-23)  白介素-23抗原

hz-0581P IL-4(Interleukin-4)  白介素4抗原

hz-1740P IL-4(Interleukin-4)human peptide  白介素4抗原

hz-1318P IL-5 peptide  白细胞介素5抗原

hz-0781P IL-6 (Interleukin-6) Human  白介素6

hz-1811P IL-7(Interleukin-7)  白介素7抗原

hz-1805P IL-6R Alpha (IL6R-alpha)  白细胞介素6受体α抗原

hz-1459P gp130/IL-6R  白介素-6受体抗原

hz-1540P IL-7Ra/CD127 peptide  白细胞介素-7受体a抗原