反义导向分子RGMA抗体

英文名称    RGMA    

中文名称    反义导向分子RGMA抗体    

别    名    Repulsive guidance molecule A; RGM domain family member A; RGMA; RGMA_HUMAN.    

反义导向分子RGMA抗体      

说 明 书    0.2ml      

研究领域    细胞生物  发育生物学  神经生物学  细胞表面分子      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Pig, Cow,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    28kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule A    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

反义导向分子RGMA抗体产品介绍    background:
The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure, but unlike ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc cause the autosomal recessive disorder juvenile hemochromatosis (JH). 

Function:
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Subunit:
Interacts with NEO1, BMP2 and BMP4 

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor 

Similarity:
Belongs to the repulsive guidance molecule (RGM) family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications    

反义导向分子RGMA抗体

hz-1188P FRA2/FOSL2(Fos related/like antigen 2)  FOS样抗原2

hz-2585P FOXF1(Forkhead box protein F1)  叉头蛋白F1抗原

hz-1775P FOXJ1/HFH-4 peptide  插头蛋白J1抗原

hz-1275P FoxP1(Forkhead box P1)  FoxP1（T细胞转录因子）抗原

hz-2687P FOXM1/HFH 11 peptide  插头蛋白M1抗原

hz-0886P Measles virus of fusion protein  麻疹病毒抗原（麻疹病毒融合蛋白）

hz-0895P FSH-R(Follicle-stimulating hormone receptor precursor)  促卵泡刺激素受体抗原

hz-1536P FSH(Follicle-stimulating hormone precursor)  促卵泡刺激素抗原

hz-1232P GABRA1(gamma-aminobutyric acid (GABA) A receptor, alpha 1)  γ1氨基丁酸A型受体α1抗原

hz-0533P GABAB1(GABAb Receptor 1)  g-氨基丁酸B1受体(多肽)

hz-1293P GABABR2/GB2(GABA B Receptor 2)  γ1氨基丁酸A型受体B2抗原

hz-1302P GAD-67 (glutamate decarboxylase 67)  谷氨酸脱羧酶-67抗原

hz-1361P GADD153(Growth arrest and DNA damage-inducible 153)  生长抑制DNA损伤基因153抗原

hz-1641P phospho GAP-43(pSer41)(phospho Growth associated protein 43 )  磷酸化神经生长相关蛋白43抗原

hz-0834P GAPDH  3-磷酸甘油醛脱氢酶(人)抗原

hz-2209P CXCR3/CD183 peptide  细胞表面趋化因子受体3抗原

hz-1452P GATA-3(GATA binding factor 3)  GATA结合蛋白3抗原

hz-1778P GATA-4(GATA binding factor 4)  GATA结合蛋白4抗原

hz-1250P Gax(growth arrest-specific homeobox)  生长终止特异性同源盒基因抗原

hz-1288P GDF8/MSTN(growth differntiation factor 8)  生长分化因子8抗原

hz-1024P GDNF (Glial cell line-derived neurotrphic factor)  胶质细胞源性神经营养因子抗原

hz-1160P Gelsolin  凝溶胶蛋白抗原

hz-0844P GFP  绿色荧光蛋白

hz-0890P GFP  绿色荧光蛋白

hz-1173P GITR (glucocorticoidinduced tumor necrosis factor receptor)  糖皮质激素诱导肿瘤坏死因子受体抗原

hz-1206P GLI1(GLI-Kruppel family mhzber 1)  下游转录因子Gli1蛋白抗原

hz-0933P GLP-1/KG-31(Glucagon-like peptide-1) peptide  胰高血糖素样肽-1（多肽）

hz-0085P GLP-1 peptide  胰高血糖素样肽-1（多肽）

hz-1559P GLP-1R peptide  胰高血糖素样肽-1受体多肽

hz-1207P GLUT3(Glucose transporter 3)  葡萄糖转运蛋白3抗原

hz-0999P GM-CSF(Granulocyte-Macrophage Colony Stimulating Factors)  粒细胞-巨噬细胞克隆刺激因子抗原

hz-1226P GPA33(glycoprotein A33 transmhzbrane)  糖蛋白A33(跨膜)抗原

hz-2426P glypican 1  磷脂酰基醇蛋白聚糖-1抗原