Rho相关蛋白激酶2抗体

英文名称    ROCK1 + ROCK2    

中文名称    Rho相关蛋白激酶2抗体    

别    名    p164 ROCK 2; p164 ROCK-2; Rho associated coiled coil containing protein kinase 2; Rho associated protein kinase 2; Rho kinase 2; ROCK 2; Rock II; Rock2m; ROK alpha; ROKalpha; coiled-coil-containing protein kinase 2; KIAA0619; Rho associated, coiled coil containing protein kinase II; Rho-associated; Rho-associated protein kinase 2; Rock2; ROCK2_HUMAN; ROCK1_HUMAN; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK. .    

Rho相关蛋白激酶2抗体         

说 明 书    0.1ml  0.2ml      

研究领域    

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    161kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human ROCK1 and ROCK    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

Rho相关蛋白激酶2抗体    产品介绍    background:
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008].

Function:
Regulates the assembly of the actin cytoskeleton. Promotes formation of stress fibers and of focal adhesion complexes. Plays a role in smooth muscle contraction.

Subunit:
Cytoplasm. Cell membrane. Cytoplasmic, and associated with actin microfilaments and the plasma membrane.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.Phosphorylation at Tyr-722 reduces its binding to RHOA and iscrucial for focal adhesion dynamics. Dephosphorylation by PTPN11stimulates its RHOA binding activity. 
Cleaved by granzyme B during apoptosis. This leads toconstitutive activation of the kinase and membrane blebbing.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thrprotein kinase family. 
Contains 1 AGC-kinase C-terminal domain. 
Contains 1 PH domain. 
Contains 1 phorbol-ester/DAG-type zinc finger. 
Contains 1 protein kinase domain. 
Contains 1 REM (Hr1) repeat.

Gene ID:
6093
9475

Database links:

Entrez Gene: 6093 Human

Entrez Gene: 19877 Mouse

Entrez Gene: 81762 Rat

Omim: 601702 Human

SwissProt: Q13464 Human

SwissProt: P70335 Mouse

SwissProt: Q63644 Rat

Unigene: 306307 Human

Unigene: 6710 Mouse

Unigene: 89756 Rat

Entrez Gene: 9475 Human

Entrez Gene: 19878 Mouse

Entrez Gene: 25537 Rat

Omim: 604002 Human

SwissProt: O75116 Human

SwissProt: P70336 Mouse

SwissProt: Q62868 Rat

Unigene: 58617 Human

Unigene: 681743 Human

Unigene: 276024 Mouse

Unigene: 88642 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

Rho相关蛋白激酶2抗体    

hz-1210P BRCA2(Breast cancer susceptbility gene 2)  乳腺癌易感基因2抗原

hz-0182P PTP-1B (Protein-tyrosine phosphatase, non-receptor )  蛋白酪氨酸磷酸酶-1B（抗原）

hz-0251P RAR-Alpha (Retinoic acid -R-Alpha)  维甲酸受体-α 多肽

hz-0319P glycoprotein (E1 glycoprotein) [Rubella virus]  风疹病毒糖蛋白多肽片段

hz-0121P SAP-1 (Synapse associated protein-I) peptide  突触相关蛋白-1（多肽抗原）

hz-0130P SARS S-protein(抗原)  

hz-0132P SARS putative orflab polyprotein (SARS coronavirus CUHK-W1)(抗原)  

hz-4813-P 禽流感H5亚型全病毒抗原  H5N1-H5

hz-1954P BSEP peptide  胆汁酸盐输出泵蛋白抗原

hz-0088P Secretin  分泌素（抗原）

hz-0089P Secretin receptor  分泌素受体（抗原）

hz-0113P Socs 1 (suppressor of cytokine signaling 1)  细胞激酶信号-1抑制剂（抗原）

hz-0259P SM-MHC(Cardiac myosin heavy chain)  心肌肌凝蛋白多肽

hz-0009P Alpha-Synuclein  核突触蛋白（抗原）

hz-0012P Alpha-Synuclein  核突触蛋白（抗原）

hz-1239P CA15-3 peptide  乳腺癌相关抗原抗原

hz-0064P Substance P Receptor (Neurokinin receptor1;Tachykinin receptor1)  P物质受体（抗原）

hz-2082P p-Caldesmon(phosphor-Ser789)  磷酸化钙介质素抗原

hz-0123P NK-2R peptide  神经激肽A受体（多肽抗原）

hz-1099P Calpain 1  钙蛋白酶（多肽）

hz-0277P Tanis/SELS (Selenoprotein S)又称SELS  炎症负调控因子蛋白（抗原）

hz-0157P Tau protein  微管相关蛋白（抗原）

hz-0233P Telomerase (TE)  端粒酶（催化亚单位）（多肽抗原）

hz-0066P TGF-Alpha (Ttansforming Growth Factor –Alpha)  转移生长因子–α（抗原）

hz-0564P CaMK2a(calcium/calmodulin-dependent protein kinase II alpha)  钙/钙调素依赖蛋白激酶2α抗原

hz-1809P Camk1g(Calcium/calmodulin dependent protein kinase IG)  钙/钙调蛋白依赖蛋白激酶IG抗原

hz-0103P TGF- Beta1 (Ttansforming Growth Factor – Beta1)  转移生长因子–β1（抗原）

hz-0541P CaMK2b(calcium/calmodulin-dependent protein kinase II beita)  钙/钙调素依赖蛋白激酶2b抗原

hz-1306P CAP1/Park7/DJ-1  Park7/DJ-1/CAP1抗原

hz-1616P CAP2(Adenylyl cyclase-associated protein 2)  环化酶相关蛋白CAP-2抗原

hz-0100P TGF beta 2 Propeptide  转移生长因子–β2前体肽

hz-0099P TGF- Beta3 (Ttansforming Growth Factor – Beta3)  转移生长因子–β3（抗原）

hz-0117P TGF- Beta R2 peptide  转移生长因子β受体2（多肽抗原）

hz-0226P Thymosin Alpha-1  胸腺肽 α-1 （胸腺肽-Thymosin alpha-1）

hz-1105P Caspase-12  半胱胺酸蛋白酶蛋白-12(多肽)