Rad51抗体

英文名称    Rad51    

中文名称    Rad51抗体    

别    名    BRCA1/BRCA2 containing complex, subunit 5; BRCC 5; BRCC5; DNA repair protein RAD51 homolog 1; DNA repair protein rhp51; E coli RecA homolog; HGNC:9817; Homolog of E coli RecA; homolog of S cerevisiae RAD51; HRAD51; HsRad51; HsT16930; Rad 51; RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); RAD51 homolog; RAD51 homolog S. cerevisiae; RAD51 S cerevisiae homolog; RAD51A; RECA; RecA homolog E. coli; RecA like protein; RecA, E. coli, homolog of; recombination protein A.    

Rad51抗体         

说 明 书    0.1ml  0.2ml      

研究领域    肿瘤  细胞生物  发育生物学  信号转导  细胞周期蛋白      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    37kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Rad51    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

Rad51抗体 产品介绍    background:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist.

Function:
Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. 

Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels.

Tissue Specificity:
Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.

Post-translational modifications:
Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.

DISEASE:
Defects in RAD51 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.

Similarity:
Belongs to the RecA family. RAD51 subfamily.
Contains 1 HhH domain. 

Gene ID:
5888

Database links:

Entrez Gene: 5888 Human

Entrez Gene: 19361 Mouse

Entrez Gene: 499870 Rat

Omim: 179617 Human

SwissProt: Q06609 Human

SwissProt: Q08297 Mouse

Unigene: 631709 Human

Unigene: 330492 Mouse

Unigene: 20474 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     

Rad51抗体 

hz-0166P NKR ； Neurokin B receptor (Neuromedin K receptor; NK-4 receptor)  神经激肽-B受体（抗原）

hz-0519P ATF3 (Activating Transcription Factor3)  活化转录因子3抗原

hz-1370P ATM(ataxia telangiectasia mutated)  毛细血管扩张性共济失调症突变蛋白抗原

hz-1634P ATF6(activating transcription factor 6)  活化转录因子6抗原

hz-1152P ATP1b2/Na+K+ ATPase(ATPase, Na+/K+ transporting, beta 2 polypeptide)  钠钾ATP酶通道蛋白抗原

hz-2436P Kir6.2 peptide  ATP敏感性钾通道亚基kir6.2抗原

hz-1705P AVPR2(arginine vasopressin receptor 2)  精氨酸加压素受体2抗原

hz-2445P Aurora B  极光激酶B抗原

hz-0075P Nociceptin  孤菲肽（痛敏肽）（抗原）

hz-1103P B7-H1/PDL1/CD274(programmed death ligand 1)  程序性死亡配体1（多肽）

hz-0181P Nociceptin receptor  孤菲肽受体（痛敏肽受体）（抗原）

hz-0134P Nogo-A  轴索过度生长抑制因子-A（抗原）

Y-0198P Nogo-66 1-40  Nogo-66 (1-40)

hz-0129P Nogo R  轴索过度生长抑制因子受体（多肽抗原）

hz-0892P Bad (BCL-xL/BCL-2-associated death promoter)  相关死亡促进因子Bad抗原

hz-1304P Bad (BCL-xL/BCL-2-associated death promoter)  相关死亡促进因子Bad抗原

hz-0893P phospho-BAD(pSer128)  磷酸化相关死亡促进因子抗体

hz-1284P Bak(BCL2 homologous antagonist/killer)  Bcl-2同源拮抗剂Bak（多肽）

hz-0156P NOS-1(bNOS:neuronal NOS:nNOS:Nitric Oxide synthase-1)  一氧化氮合成酶-1（抗原）

hz-0162P NOS-2 (iNOS) Nitric Oxide Synthase,Inducible  一氧化氮合成酶-2（抗原）

hz-0911P Batroxobin  蛇毒巴曲酶抗原

hz-0163P NOS-3 (eNOS) endotheli cell NOS  一氧化氮合成酶-3（抗原）

hz-0071P NPY ( Neuropeptide Y)  神经肽 Y（抗原）

hz-0222P NR2B (Glutamate receptor)  谷氨酸受体（抗原）

hz-0160P NT-3  神经生长因子-3（抗原）

hz-0158P NT-4,NT-5  神经生长因子4/5（抗原）

hz-0073P NTN (Neurturin)  神经生长因子（抗原）

hz-1336P Bcl-xL(human, mo, rat, bovine, dog, pig, sheep, horse)  Bcl-xL蛋白抗原

hz-1337P phospha-Bcl-xL (pSer62) peptide (human, mo, rat, bovine, dog, pig, sheep, horse)  磷酸化(Ser62)Bcl-xL蛋白抗原

hz-0986P BCHE(butyrylcholinesterase)NT  丁酰胆碱脂酶抗原(N端)

hz-0987P BCHE(butyrylcholinesterase)CT  丁酰胆碱脂酶抗原(C端)

hz-0178P Nurr1  核受体相关因子-1（抗原）

hz-0372P NT5C2  胞浆-5′-核苷酸酶-Ⅱ