磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体

英文名称    phospho-RASA1 (Tyr460)    

中文名称    磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体    

别    名    GAP (phospho Y460); p-GAP (phospho Y460); Ras GAP; CM AVM; CMAVM; DKFZp434N071; GAP; GTPase activating protein; GTPase-activating protein; OTTHUMP00000222390; OTTHUMP00000222391; OTTHUMP00000222392; OTTHUMP00000222393; p120GAP; p120RASGAP; PKWS; Ras GTPase-activating protein 1; RAS p21 protein activator (GTPase activating protein) 1; Ras p21 protein activator; RASA; RASA1; RASA1_HUMAN; RasGAP; Triphosphatase activating protein.    

磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体        

说 明 书    0.1ml      

产品类型    磷酸化抗体     

研究领域    肿瘤  细胞生物  信号转导  G蛋白偶联受体  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    116kDa    

细胞定位    细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthesised phosphopeptide derived from human GAP around the phosphorylation site of Tyr460    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体 产品介绍    background:
The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode ubiquitously expressed proteins (1,2). p21Ras can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state (3). Oncogenic p21Ras proteins are trapped in the excited signal-emitting state because the mechanism normally employed to delimit their excitation period, hydrolysis of their bound GTP to GDP, is impaired as a result of specific mutations (3). Interaction of p21Ras with GTPase activating protein (GAP) can increase hydrolysis of p21Ras-bound GTP by as much as 1000-fold (4,5). The product of the neurofibromatosis type 1 gene (NF1) has also been shown to exhibit p21Ras GAP activity (6,7), and proteins that stimulate the GTPase activity of three other low molecular weight GTPases, including Rho, Rab 3A and Rap 1, have also been described (8,9).

Function:
Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.

Subunit:
Interacts with SQSTM1. Interacts with SPSB1; the interaction does not promote degradation. Interacts with CAV2 (tyrosine phosphorylated form). Directly interacts with NCK1. Interacts with PDGFRB (tyrosine phosphorylated). Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).

DISEASE:
Note=Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas.
Defects in RASA1 are the cause of capillary malformation-arteriovenous malformation (CMAVM) [MIM:608354]. CMAVM is a disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome.
Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:608355]. PKWS is a disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.

Similarity:
Contains 1 C2 domain.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.
Contains 2 SH2 domains.
Contains 1 SH3 domain. 

Database links:
UniProtKB/Swiss-Prot: P20936.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体 

hz-0187P IRS-4  胰岛素受体底物-4（抗原）

hz-1554P AQP5(aquaporin Protein-5)  水通道蛋白-5抗原

hz-0242P IRS P53 (Insulin receptor substrate P53)(多肽)  

hz-2639P PGE2 peptide  前列腺素E2抗原

hz-0342P Integrin Beta chain (ITG- Beta3/ITGB3)  整合素-β3（抗原）

hz-2060P AQP9(aquaporin Protein-9)  水通道蛋白-9抗原 (多肽抗原)

hz-0108P Leptin  瘦素（多肽抗原）

hz-0109P Leptin receptor(long)  瘦素受体（长）（抗原）

hz-0943P phospho-AR/androgen receptor( p-Ser580)peptide  雄激素受体（多肽）

hz-0022P MAPK-1/2  丝裂原活化蛋白激酶（抗原）

hz-0223P MAPKK2  丝裂原活化蛋白激酶激酶

hz-0101P M2-PK ( pyruvate Kinase M2)  丙酮酸激酶-M2（抗原）

hz-0102P M2-PK ( pyruvate Kinase M2 )  丙酮酸激酶-M2（抗原）

hz-2201P p-Arhgef2/GEF-H1(Rho guanine nucleotide exchange factor 2,pSer810)  磷酸化Rho鸟苷酸交换因子2抗原

hz-0051P Melan-A/MART-1  黑色素-A（抗原）

hz-0804P ARIP2a(Activin receptor 2A)  激活素受体2A/激活素受体相互作用蛋白2a抗原

hz-0857P Beta-arrestin 1/2(beta-arrestin 1/2)  β-抑制蛋白1/2抗原

hz-0801P ARIP2B(Activin receptor 2B)  激活素受体2B/激活素受体相互作用蛋白2b抗体

hz-0027P MTR-1A (Melatonin receptor-1A)  褪黑素受体（抗原）

hz-0334P MTLC (c-Myc target from laryngeal cancer cells)又称：MYC  致癌基因（抗原）

hz-0224P N-coR1 (Nuclear receptor co-repressor 1)  核受体辅助抑制因子（抗原）

hz-0006P Nestin  巢蛋白（神经上皮干细胞蛋白）（抗原）

hz-0600P AR Alpha1( Alpha1-adrenergic receptor)  α1肾上腺素能受体抗原

hz-11018P Apelin36  脂肪炎症因子Apelin36

hz-0008P Nestin  巢蛋白（神经上皮干细胞蛋白）（抗原）

hz-1155P ASCL1/MASH1(Achaete-scute homolog 1)  神经母细胞特异性转移因子抗原

hz-1282P ASPP1(apoptosis stimulating protein of P53 1)  p53凋亡刺激蛋白1抗原

hz-1283P ASPP2(apoptosis stimulating protein of P53 2)  P53凋亡刺激蛋白2抗原

hz-0289P neurofasciu-155  神经束蛋白-155

hz-0067P NGF- Beta  神经生长因子-β(多肽片断抗原)

hz-1707P Ang I/AT1(Angiotensin I)  血管紧张素I抗原

hz-0161P NGF-R(p75NTR)  神经生长因子受体（抗原）

hz-0630P AT1R(Angiotensin II Type 1 Receptor)  血管紧张素Ⅱ-1型受体抗原

hz-2097P AT1R/AGTR1(Angiotensin II Type 1 Receptor)  血管紧张素Ⅱ-1型受体抗原

hz-0074P NIK，NF-kappaB-Inducing Kinase  NFkB诱导的激酶（抗原）

hz-0517P ATF1 (Activating Transcription Factor1)  活化复制因子1

hz-0070P NKB (Neurokinins B)  神经激肽B（抗原）

hz-0518P ATF2 (Activating Transcription Factor2)  活化复制因子2（多肽）

hz-1648P phospho-ATF2(pSer490/pSer498)  磷酸化活化复制因子2抗原