G蛋白偶联受体RAB23抗体

英文名称    RAB23    

中文名称    G蛋白偶联受体RAB23抗体    

别    名    DKFZp781H0695; HSPC137; MGC8900; Rab 23; RAB family small GTP binding protein RAB 23; Rab23; RAB23, member RAS oncogene family; RAB23_HUMAN; Ras related protein Rab 23; Ras-related protein Rab-23.    

G蛋白偶联受体RAB23抗体       

说 明 书    0.2ml      

研究领域    肿瘤  染色质和核信号  神经生物学  干细胞  G蛋白偶联受体  G蛋白信号      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    23kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RAB23    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

G蛋白偶联受体RAB23抗体产品介绍    background:
The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 23, also known as HSPC137, is a 237 amino acid member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. Rab 23 is believed to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. Mutations in the gene encoding Rab 23 may result in Carpenter syndrome, also known as ACPS2 (acrocephalopolysyndactyly type 2), a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis.

Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. 

Subunit:
Interacts with SUFU.

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Cell membrane. Cytoplasm. Cytoplasmic vesicle, autophagosome. Endosome membrane (By similarity). Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. 

DISEASE:
Defects in RAB23 are the cause of acrocephalopolysyndactyly type 2 (ACPS2) [MIM:201000]. A syndrome characterized by craniosynostosis, polysyndactyly, obesity, and cardiac defects.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

Database links:
UniProtKB/Swiss-Prot: Q9ULC3.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

G蛋白偶联受体RAB23抗体

hz-2031P MBP (Myelin Basic Protein, Rat)peptide  髓鞘碱性蛋白(多肽）大鼠

hz-0426P MOG35-55 (myelin oligo-dendrocyte glycoprotein-MOG)  髓鞘少树突胶质细胞糖蛋白(活性多肽)

hz-0014P IGF-I( Insulin-like Growth Factor-I )  胰岛素样生长因子-I（抗原）

hz-0077P VIP (Vasoactive Intestinal peptide)  血管活性肠肽

hz-0015P IGF-II( Insulin-like Growth Factor-II )  胰岛素样生长因子-II（抗原）

hz-0392P TP-5(Thymopentin)  胸腺五肽

hz-0017P Galanin  神经节肽

hz-0841P GLP-2(Glucagon-like peptide-2)  胰高血糖素样肽-2蛋白

hz-0039P ADNP (NAP) (Activity-dependent Neuroprotective protein )  活性依赖的神经保护肽(抗原）

hz-0094P AACT(Alpha-1-Anti-chymotrypsin)  α-1抗胰糜蛋白酶

hz-2179P AACT protein(Alpha chymotrypsin protein)  胰糜蛋白酶

hz-0443P ACTH (Adrenorticotrophin hormons)(1-39)  促肾上腺皮质激素(1-39)（抗原）

Y-0133 ADM 1-52/AM 1-52 (Adrenomedullin 1-52)  肾上腺髓质素(1-52)

hz-0311PK Biotin/KLH  生物素偶联血蓝蛋白

hz-0311PB Biotin/BSA  生物素偶联牛血清白蛋白

hz-0442P ACTH (Adrenorticotrophin hormons)(18-39)  促肾上腺皮质激素（18-39）(抗原)

hz-0065P SP (Substance P)  P物质（抗原）

hz-0467P Ghrelin  脑肠肽(一种新的生长激素释放肽)多肽抗原

hz-0482P Gastrin(human)peptide(1-17)  胃泌素/蛙皮素（多肽人源）

hz-0337P myelin P0 prothein( peripheral myelin prothein Zero;MPZ;MPP)  外周髓鞘蛋白0(P0蛋白)多肽抗原

hz-0789P Insulin protein (from porcine pancreas)  猪胰岛素

P0005 bovine Insulin protein   牛胰岛素蛋白

hz-0865P Tachyplesin I(Tachyplesin-1 precursor )  抗菌肽

hz-0357P TRH (Thyrotropin releasing hormone )  促甲状腺素释放激素

hz-0435P PAR-2 AP (Protease-activated receptors-2 Activating polypeptide)  蛋白酶激活受体-2激活肽

hz-0590P Cygb (cytoglobin)  细胞球蛋白抗原

hz-0436P PAR-2 OP(Protease-activated receptors-2 Activating Orange-peptide)  蛋白酶激活受体-2桔抗肽

hz-0352P DLX4 (Dsital-less homebox4 isoformAlpha/ Beta)  末梢同源匡基因多肽片段

hz-0918P ShK(Stichodactyla helianthus Neurotoxin)  海葵神经毒素（35肽）

hz-1490P ShK(Stichodactyla helianthus Neurotoxin)-(Ala22)  海葵神经毒素（35肽）

hz-1491P ShK(Stichodactyla helianthus Neurotoxin)-(Arg22)  海葵神经毒素（35肽）

hz-1492P ShK(Stichodactyla helianthus Neurotoxin)-(Dap22)  海葵神经毒素（35肽）

hz-1320P ShK(Stichodactyla helianthus Neurotoxin)-(Gln9)  海葵神经毒素（35肽）

hz-1321P ShK(Stichodactyla helianthus Neurotoxin)-(Gln11)  海葵神经毒素（35肽）

hz-2000Pr rHBcAg  重组乙肝病毒核心抗原

hz-1662P rHBeAg(Hepatitis B Virus E Antigen protein)  重组乙肝病毒e抗原

hz-2005P rDen(rh-Dengue Virus)  多价重组人登革热病毒诊断抗原