维甲酸相关孤儿受体α抗体

英文名称    ROR alpha    

中文名称    维甲酸相关孤儿受体α抗体    

别    名    NR1F1; Nuclear receptor ROR alpha; Nuclear receptor RZR alpha; RAR related orphan receptor A; RAR related orphan receptor alpha; ROR 1; ROR 2; ROR 3; ROR A; ROR1; ROR2.    

维甲酸相关孤儿受体α抗体       

说 明 书    0.2ml      

研究领域    肿瘤  细胞生物  染色质和核信号  神经生物学  细胞周期蛋白  细胞分化      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    100kDa    

细胞定位    细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human ROR1/ROR alpha (301-360aa)    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

维甲酸相关孤儿受体α抗体产品介绍    background:
NR1F1; Retinoid related orphan receptor alpha (ROR alpha) is a NR1 Thyroid Hormone Like Receptor. ROR alpha has been shown to affect the development of the central nervous system. Deletion of ROR alpha in mice causes severe impairment in the differentiation of cerebellar Purkinje neurons and results in the "staggerer" phenotype. ROR alpha has been suggested as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis. Within the ROR alpha group there are ROR alpha 1, 2, 3, and 4. These isotypes have been shown to differ in only their amino terminus, and their spatiotemporal expression appears to be under isoform specific regulation. ROR alpha isoforms have the same DNA binding domain but display different DNA binding specificities. ROR alpha 1 binds to and constitutively activates transcription from a large subset of ROR elements, while ROR alpha 2 recognizes ROR elements with strict specificity and displays weaker transcriptional activity. The structure of the ligand binding domain (LBD) of ROR alpha and a potential natural ligand have been elucidated. ROR alpha expression has been documented in human adipose, brain, breast, heart, liver, lung, muscle, ovary, PBLs, prostate, small intestine, spleen and testis. Research has shown that these proteins are key factors in the regulation of many physiological processes such as cell growth and differentiation. ROR alpha is also critical for proper cerebellar development, modulation of gene expression in response to hypoxic stress, and migratory capacities of cancer cells. 

Function:
Tyrosine-protein kinase receptor whose role is not yet clear.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Contains 1 FZ (frizzled) domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 kringle domain.
Contains 1 protein kinase domain. 

Database links:

Entrez Gene: 6095 Human

Entrez Gene: 19883 Mouse

Entrez Gene: 300807 Rat

Omim: 600825 Human

SwissProt: P35398 Human

SwissProt: P51448 Mouse

Unigene: 560343 Human

Unigene: 655155 Human

Unigene: 378450 Mouse

Unigene: 391890 Mouse

Unigene: 427266 Mouse

Unigene: 490614 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

维甲酸相关孤儿受体α抗体

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hz-0403R-AF350 Rabbit anti-MG IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗长爪沙鼠IgG

hz-0403R-AF488 Rabbit anti-MG IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗长爪沙鼠IgG

hz-0403R-AF555 Rabbit anti-MG IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗长爪沙鼠IgG

hz-0403R-AF647 Rabbit anti-MG IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗长爪沙鼠IgG

hz-0403R-PE-hzy5.5 Rabbit anti-MG IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗长爪沙鼠IgG

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hz-0403R-Gold Rabbit anti-MG IgG/Gold  胶体金标记的兔抗长爪沙鼠IgG

hz-0403R-HRP Rabbit anti-MG IgG/HRP  辣根过氧化物酶标记的兔抗长爪沙鼠IgG

hz-0777R-HRP Rabbit Anti-Mink IgG/HRP  辣根过氧化物酶标记的兔抗水貂IgG

hz-0777R-hzy3 Rabbit Anti-Mink IgG/Cy3  Cy3标记的兔抗水貂IgG

hz-0777R-hzy5 Rabbit Anti-Mink IgG/Cy5  Cy5标记的兔抗水貂IgG

hz-0777R-hzy5.5 Rabbit Anti-Mink IgG/Cy5.5  Cy5.5标记的兔抗水貂IgG

hz-0777R-hzy7 Rabbit Anti-Mink IgG/Cy7  Cy7标记的兔抗水貂IgG

hz-0777R-PE Rabbit Anti-Mink IgG/PE  PE标记的兔抗水貂IgG

hz-0777R-PE-hzy3 Rabbit Anti-Mink IgG/PE-Cy3  PE-Cy3标记的兔抗水貂IgG

hz-0777R-PE-hzY5 Rabbit Anti-Mink IgG/PE-CY5  PE-CY5标记的兔抗水貂IgG

hz-0777R-APhz Rabbit Anti-Mink IgG/APC  APC标记的兔抗水貂IgG

hz-0777R-AF350 Rabbit Anti-Mink IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗水貂IgG

hz-0777R-AF488 Rabbit Anti-Mink IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗水貂IgG

hz-0777R-AF555 Rabbit Anti-Mink IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗水貂IgG

hz-0777R-AF647 Rabbit Anti-Mink IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗水貂IgG

hz-0777R-PE-hzy5.5 Rabbit Anti-Mink IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗水貂IgG

hz-0777R-PE-hzy7 Rabbit Anti-Mink IgG/PE-Cy7  PE-Cy7标记的兔抗水貂IgG

hz-0777R-AP Rabbit Anti-Mink IgG/AP  碱性磷酸酶（AP）标记的兔抗水貂IgG

hz-0777R-Gold Rabbit Anti-Mink IgG/Gold  胶体金标记的兔抗水貂IgG

hz-0777R-Bio Rabbit Anti-Mink IgG/Bio  生物素标记的兔抗水貂IgG

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hz-0297D-Gold Donkey Anti-human IgG/Gold  胶体金标记的驴抗人IgG

hz-0297D-FIThz Donkey Anti-human IgG/FITC  FITC标记的驴抗人IgG

hz-0297D-hzy3 Donkey Anti-human IgG/Cy3  Cy3标记的驴抗人IgG