β1,3-N-乙酰糖基转移酶抗体

英文名称    Radical Fringe    

中文名称    β1,3-N-乙酰糖基转移酶抗体    

别    名    3-N-acetylglucosaminyltransferase radical fringe; Beta-1; Beta-1,3-N-acetylglucosaminyltransferase radical fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; RFNG; RFNG_HUMAN.    

β1,3-N-乙酰糖基转移酶抗体         

说 明 书    0.1ml  0.2ml      

研究领域    神经生物学  信号转导  干细胞      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    36kDa    

细胞定位    细胞浆 细胞膜     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human Radical Fringe    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

β1,3-N-乙酰糖基转移酶抗体 产品介绍    background:
Three mammalian fringe family members, Manic, Radical and Lunatic Fringe, have been identified as proteins related to Drosophila Fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination during segmentation. Each mammalian Fringe displays different patterns of expression, though all are expressed in the mouse embryo as well as in many adult tissues. Radical Fringe, also known as Beta-1,3-N-acetylglucosaminyltransferase Radical Fringe, is a 331 amino acid single-pass type II membrane protein that localizes to the membrane of the Golgi apparatus. Playing a key role in the development of the limb bud, Radical Fringe transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. Lunatic Fringe is required for normal somite segmentation and patterning and is thought to be a target of the molecular clock. Manic Fringe, also involved in somatic development, has been shown to render mouse NIH/3T3 cells tumorigenic in SCID mice.

Function:
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis.

Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein (Potential). 

Similarity:
Belongs to the glycosyltransferase 31 family.

Gene ID:
5986

Database links:

Entrez Gene: 5986 Human

Entrez Gene: 19719 Mouse

Entrez Gene: 60433 Rat

Omim: 602578 Human

SwissProt: Q9Y644 Human

SwissProt: O09009 Mouse

SwissProt: Q9R1U9 Rat

Unigene: 569700 Human

Unigene: 871 Mouse

Unigene: 168817 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

β1,3-N-乙酰糖基转移酶抗体 

hz-0377R-hzy7 Rabbit Anti-mouse IgG-Fc/Cy7  Cy7标记的兔抗小鼠IgG-Fc

hz-0377R-PE Rabbit Anti-mouse IgG-Fc/PE  PE标记的兔抗小鼠IgG-Fc

hz-0377R-FIThz Rabbit Anti-mouse IgG-Fc/FITC  FITC标记的兔抗小鼠IgG-Fc

hz-0377R-RBIThz Rabbit Anti-mouse IgG-Fc/RBITC  罗丹明标记的兔抗小鼠IgG-Fc

hz-0377R-Bio Rabbit Anti-mouse IgG-Fc/Bio  生物素标记的兔抗小鼠IgG-Fc

hz-0335R-RBIThz Rabbit Anti-Monkey IgG/RBITC  罗丹明标记的兔抗猴IgG

hz-0335R-FIThz Rabbit Anti-Monkey IgG/FITC  FITC标记的兔抗猴IgG

hz-0335R-HRP Rabbit Anti-Monkey IgG/HRP  辣根过氧化物酶标记的兔抗猴IgG

hz-0335R-Gold Rabbit Anti-Monkey IgG/Gold  胶体金标记的兔抗猴IgG

hz-0335R-AP Rabbit Anti-Monkey IgG/AP  碱性磷酸酶（AP）标记的兔抗猴IgG

hz-0335R-Bio Rabbit Anti-Monkey IgG/Bio  生物素标记的兔抗猴IgG

hz-0335R-hzy3 Rabbit Anti-Monkey IgG/Cy3  Cy3标记的兔抗猴IgG

hz-0335R-hzy5 Rabbit Anti-Monkey IgG/Cy5  Cy5标记的兔抗猴IgG

hz-0335R-hzy5.5 Rabbit Anti-Monkey IgG/Cy5.5  Cy5.5标记的兔抗猴IgG

hz-0335R-hzy7 Rabbit Anti-Monkey IgG/Cy7  Cy7标记的兔抗猴IgG

hz-0335R-PE Rabbit Anti-Monkey IgG/PE  PE标记的兔抗猴IgG

hz-0335R-PE-hzy3 Rabbit Anti-Monkey IgG/PE-Cy3  PE-Cy3标记的兔抗猴IgG

hz-0335R-PE-hzY5 Rabbit Anti-Monkey IgG/PE-CY5  PE-CY5标记的兔抗猴IgG

hz-0335R-APhz Rabbit Anti-Monkey IgG/APC  APC标记的兔抗猴IgG

hz-0335R-AF350 Rabbit Anti-Monkey IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗猴IgG

hz-0335R-AF488 Rabbit Anti-Monkey IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗猴IgG

hz-0335R-AF555 Rabbit Anti-Monkey IgG/Alexa Fluor 555  Alexa Fluor 555标记的兔抗猴IgG

hz-0335R-AF647 Rabbit Anti-Monkey IgG/Alexa Fluor 647  Alexa Fluor 647标记的兔抗猴IgG

hz-0335R-PE-hzy5.5 Rabbit Anti-Monkey IgG/PE-Cy5.5  PE-Cy5.5标记的兔抗猴IgG

hz-0335R-PE-hzy7 Rabbit Anti-Monkey IgG/PE-Cy7  PE-Cy7标记的兔抗猴IgG

hz-0336R-hzy3 Rabbit Anti-Monkey IgM/Cy3  Cy3标记的兔抗猴IgM

hz-0336R-hzy5 Rabbit Anti-MK IgM/Cy5  Cy5标记的兔抗猴IgM

hz-0336R-hzy5.5 Rabbit Anti-MK IgM/Cy5.5  Cy5.5标记的兔抗猴IgM

hz-0336R-hzy7 Rabbit Anti-MK IgM/Cy7  Cy7标记的兔抗猴IgM

hz-0336R-PE Rabbit Anti-MK IgM/PE  PE标记的兔抗猴IgM

hz-0336R-APhz Rabbit Anti-MK IgM/APC  APC标记的兔抗猴IgM

hz-0336R-AF350 Rabbit Anti-MK IgM/Alexa Fluor 350  Alexa Fluor 350标记的兔抗猴IgM