转录调控因子RFX4抗体

英文名称    RFX4    

中文名称    转录调控因子RFX4抗体    

别    名    NYD SP10; Regulatory factor X 4; Regulatory factor X, 4 (influences HLA class II expression); Regulatory factor X4 isoform E; Regulatory factor X4 isoform F; Regulatory factor X4, isoform c; Regulatory factor X4, isoform d; Transcription factor RFX4; Winged helix transcription factor RFX4 variant 3; RFX4_HUMAN.    

转录调控因子RFX4抗体      

说 明 书    0.1ml  0.2ml      

研究领域    细胞生物  免疫学  神经生物学  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, Guinea Pig,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    83kDa    

细胞定位    细胞核     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human RFX4    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

转录调控因子RFX4抗体产品介绍    background:
EP and EP-like sites are regulatory enhancer elements found in the promoters of several viral and mammalian genes which, in humans, include the MIF-1 binding site (MIE) of the c-Myc gene, the X box of MHC class II promoters and a binding site in the PCNA (proliferating cell nuclear antigen) promoter. The EP-like sites present in the X box of MHC class II promoters are distinctly nonpalindromic sequences that contain only a single EP-homologous half-site. The EP-like element is bound by a ubiquitous nuclear protein complex that consists of homo- and heterodimers involving the RFX1, RFX2, RFX3, RFX4 and RFX5 proteins. The RFX proteins represent an essential class II transcription factor family that share several conserved regions, including a centrally located DNA-binding domain (DBD) and a C-terminal D region that facilitates dimerization. RFX4 is a 735 amino acid nuclear protein that, via interactions with other RFX proteins, can bind DNA and is thought to activate the transcription of target genes. Four isoforms, each of which exhibit different tissue specificity, exist due to alternative splicing events.

Function:
RFX4 is a transcription factors that contain a highly-conserved winged helix DNA binding domain. RFX4 is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. RFX4 may be a transcriptional repressor rather than a transcriptional activator.This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.

Subunit:
Homodimer. Heterodimer with RFX2 and RFX3. Binds DNA.

Subcellular Location:
Nuclear

Tissue Specificity:
Isoform 4 is testis-specific. Isoform 1 is expressed in brain and gliomas. Isoform 2 and isoform 3 are testis-specific (at protein level). Isoform 1 is expressed in brain (at protein level). Isoform 3 is expressed at a higher level in adult testes and ejaculated spematozoa than in fetal testes. 

Similarity:
Belongs to the RFX family. 
Contains 1 RFX-type winged-helix DNA-binding domain. 

Gene ID:
5992

Database links:

Entrez Gene: 5992 Human

Entrez Gene: 71137 Mouse

Entrez Gene: 500818 Rat

Omim: 603958 Human

SwissProt: Q33E94 Human

SwissProt: Q7TNK1 Mouse

Unigene: 388827 Human

Unigene: 79070 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.    

转录调控因子RFX4抗体

hz-0358R-hzy3 Rabbit Anti-Guinea pig IgG/Cy3  Cy3标记的兔抗豚鼠IgG

hz-0358R-hzy5 Rabbit Anti-Guinea pig IgG/Cy5  Cy5标记的兔抗豚鼠IgG

hz-0358R-hzy5.5 Rabbit Anti-Guinea pig IgG/Cy5.5  Cy5.5标记的兔抗豚鼠IgG

hz-0358R-hzy7 Rabbit Anti-Guinea pig IgG/Cy7  Cy7标记的兔抗豚鼠IgG

hz-0358R-PE Rabbit Anti-Guinea pig IgG/PE  PE标记的兔抗豚鼠IgG

hz-0358R-PE-hzy3 Rabbit Anti-Guinea pig IgG/PE-Cy3  PE-Cy3标记的兔抗豚鼠IgG

hz-0358R-PE-hzY5 Rabbit Anti-Guinea pig IgG/PE-CY5  PE-CY5标记的兔抗豚鼠IgG

hz-0358R-APhz Rabbit Anti-Guinea pig IgG/APC  APC标记的兔抗豚鼠IgG

hz-0358R-AF350 Rabbit Anti-Guinea pig IgG/Alexa Fluor 350  Alexa Fluor 350标记的兔抗豚鼠IgG

hz-0358R-AF488 Rabbit Anti-Guinea pig IgG/Alexa Fluor 488  Alexa Fluor 488标记的兔抗豚鼠IgG

hz-0358R-AP Rabbit Anti-Guinea pig IgG/AP  碱性磷酸酶（AP）标记的兔抗豚鼠IgG

hz-0358R-HRP Rabbit Anti-Guinea pig IgG/HRP  辣根过氧化物酶标记的兔抗豚鼠IgG

hz-0358R-Gold Rabbit Anti-Guinea pig IgG/Gold  胶体金标记的兔抗豚鼠IgG

hz-0358R-Bio Rabbit Anti-Guinea pig IgG/Bio  生物素标记的兔抗豚鼠IgG

hz-0375R-HRP Rabbit Anti-Guinea pig IgM/HRP  辣根过氧化物酶标记的兔抗豚鼠IgM

hz-0375R-Bio Rabbit Anti-Guinea pig IgM/Bio  生物素标记的兔抗豚鼠IgM

hz-0375R-hzy3 Rabbit Anti-Guinea pig IgM/Cy3  Cy3标记的兔抗豚鼠IgM

hz-0375R-hzy5 Rabbit Anti-Guinea pig IgM/Cy5  Cy5标记的兔抗豚鼠IgM

hz-0375R-PE-hzY5 Rabbit Anti-Guinea pig IgM/PE-CY5  PE-CY5标记的兔抗豚鼠IgM

hz-0375R-APhz Rabbit Anti-Guinea pig IgM/APC  APC标记的兔抗豚鼠IgM

hz-0375R-AF350 Rabbit Anti-Guinea pig IgM/Alexa Fluor 350  Alexa Fluor 350标记的兔抗豚鼠IgM

hz-0375R-AF488 Rabbit Anti-Guinea pig IgM/Alexa Fluor 488  Alexa Fluor 488标记的兔抗豚鼠IgM

hz-0375R-AF555 Rabbit Anti-Guinea pig IgM/Alexa Fluor 555  Alexa Fluor 555标记的兔抗豚鼠IgM

hz-0375R-AP Rabbit Anti-Guinea pig IgM/AP  碱性磷酸酶（AP）标记的兔抗豚鼠IgM

hz-0375R-Gold Rabbit Anti-Guinea pig IgM/Gold  胶体金标记的兔抗豚鼠IgM

hz-0375R-AF647 Rabbit Anti-Guinea pig IgM/Alexa Fluor 647  Alexa Fluor 647标记的兔抗豚鼠IgM

hz-0375R-PE-hzy5.5 Rabbit Anti-Guinea pig IgM/PE-Cy5.5  PE-Cy5.5标记的兔抗豚鼠IgM

hz-0375R-PE-hzy7 Rabbit Anti-Guinea pig IgM/PE-Cy7  PE-Cy7标记的兔抗豚鼠IgM

hz-0375R-hzy5.5 Rabbit Anti-Guinea pig IgM/Cy5.5  Cy5.5标记的兔抗豚鼠IgM

hz-0375R-hzy7 Rabbit Anti-Guinea pig IgM/Cy7  Cy7标记的兔抗豚鼠IgM

hz-0375R-PE Rabbit Anti-Guinea pig IgM/PE  PE标记的兔抗豚鼠IgM

hz-0375R-PE-hzy3 Rabbit Anti-Guinea pig IgM/PE-Cy3  PE-Cy3标记的兔抗豚鼠IgM

hz-0375R-RBIThz Rabbit Anti-Guinea pig IgM/RBITC  罗丹明标记的兔抗豚鼠IgM

hz-0375R-FIThz Rabbit Anti-Guinea pig IgM/FITC  FITC标记的兔抗豚鼠IgM

hz-0308R-FIThz Rabbit Anti-horse IgG/FITC  FITC标记的兔抗马IgG

hz-0308R-Gold Rabbit Anti-horse IgG/Gold  胶体金标记的兔抗马IgG

hz-0308R-RBIThz Rabbit Anti-horse IgG/RBITC  罗丹明标记的兔抗马IgG