英文名称 RCAD
中文名称 RCAD蛋白抗体
别 名 K0776; E3 UFM1-protein ligase 1; KIAA0776; LZAP-binding protein; Maxer; NLBP; RCAD; UFL1; UFL1_HUMAN.
RCAD蛋白抗体
说 明 书 0.2ml
研究领域 细胞生物 免疫学 泛素
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human RCAD
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RCAD蛋白抗体产品介绍 background:
E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3.
Subcellular Location:
Endoplasmic reticulum. Cytoplasm. In cytoplasm colocalizes with CDK5RAP3.
Tissue Specificity:
Ubiquitously expressed, with a high expression in liver (at protein level). Low expression in several invasive hepatocellular carcinomas, such HepG2, Hep3B, HLE and PLC.
Post-translational modifications:
Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects each other against ubiquitination and degradation via the proteasome.
Similarity:
Belongs to the UFL1 family.
Database links:
Entrez Gene: 23376 Human
Entrez Gene: 67490 Mouse
Entrez Gene: 313115 Rat
Omim: 613372 Human
SwissProt: O94874 Human
SwissProt: Q8CCJ3 Mouse
SwissProt: B2GV24 Rat
Unigene: 149367 Human
Unigene: 226295 Mouse
Unigene: 12784 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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